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Cardium Presents Gene Activated Matrix Technology and Update on Excellarate Clinical Development Program at ASGT Annual Meeting
Date:5/28/2009

the lead investigator of the study, Dr. Peter A. Blume, DPM, FACFAS, of the Yale University School of Medicine, and a patient enrolled in the study.

Excellarate Product Candidate

As explained by Dr. Sosnowski, Excellarate is a collagen-based topical gel employing TRC's Gene Activated Matrix(TM) (GAM) technology to stimulate a patient's cells to produce a sustained micro-release of platelet-derived growth factor-B (PDGF-B) protein directly within the patient's wound where it is needed. The Excellarate product candidate is designed to require only one or two physician-administered treatments, in contrast to most diabetic wound healing agents or devices in use that require repeated administrations over a long term (weeks to months).

With regard to the biology underlying Excellarate, Dr. Sosnowski noted that PDGF-B is believed to stimulate angiogenesis and granulation tissue formation through the recruitment and proliferation of cells such as monocytes, fibroblasts and endothelial cells, which are critical for the effective stimulation of a variety of wound healing processes. The Excellarate product candidate represents a new class of advanced wound healing therapies designed to leverage the body's own natural healing abilities. Normal wound healing proceeds in an ordered sequence of events that includes control of injury and inflammation, followed by repair and remodeling. These events are mediated by the complex interactions of specific growth factors and cytokines. In the diabetic patient, this wound healing process is often impaired, in part due to a deficiency of growth factors.

Placement of a gene encoding a therapeutic growth factor into the wound environment allows for sustained and localized production of micro quantities of the growth factor by the body's own cells within the wound site, an approach designed to improve therapeutic responsiveness. To accomplis
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SOURCE Cardium Therapeutics
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