Navigation Links
Cardiovascular risk may remain for treated Cushing's disease patients
Date:2/11/2013

Chevy Chase, MD Even after successful treatment, patients with Cushing's disease who were older when diagnosed or had prolonged exposure to excess cortisol face a greater risk of dying or developing cardiovascular disease, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

Cushing's disease is a rare condition where the body is exposed to excess cortisol a stress hormone produced in the adrenal gland for long periods of time.

Researchers have long known that patients who have Cushing's disease are at greater risk of developing and dying from cardiovascular disease than the average person. This study examined whether the risk could be eliminated or reduced when the disease is controlled. Researchers found that these risk factors remained long after patients were exposed to excess cortisol.

"The longer patients with Cushing's disease are exposed to excess cortisol and the older they are when diagnosed, the more likely they are to experience these challenges," said Eliza B. Geer, MD, of Mount Sinai Medical Center and lead author of the study. "The findings demonstrate just how critical it is for Cushing's disease to be diagnosed and treated quickly. Patients also need long-term follow-up care to help them achieve good outcomes."

The study found cured Cushing's disease patients who had depression when they started to experience symptoms of the disease had an elevated risk of mortality and cardiovascular disease. Men were more at risk than women, a trend that may be explained by a lack of follow-up care, according to the study. In addition, patients who had both Cushing's syndrome and diabetes were more likely to develop cardiovascular disease.

The study examined one of the largest cohorts of Cushing's disease patients operated on by a single surgeon. The researchers retrospectively reviewed charts for 346 Cushing's disease patients who were treated between 1980 and 2011. Researchers estimated the duration of exposure to excess cortisol by calculating how long symptoms lasted before the patient went into remission. The patients who were studied had an average exposure period of 40 months.

The findings may have implications for people who take steroid medications, Geer said. People treated with high doses of steroid medications such as prednisone, hydrocortisone or dexamethasone are exposed to high levels of cortisol and may experience similar conditions as Cushing's disease patients.

"While steroid medications are useful for treating patients with a variety of conditions, the data suggests health care providers need to be aware that older patients or those who take steroid medications for long periods could be facing higher risk," Geer said. "These patients should be monitored carefully while more study is done in this area."


'/>"/>

Contact: Jenni Glenn Gingery
jgingery@endo-society.org
301-941-0240
The Endocrine Society
Source:Eurekalert

Related medicine news :

1. Original research papers on acute cardiovascular care: ESC launches EHJ-ACVC
2. Is it time for regional cardiovascular emergency care systems across the US?
3. New guidelines deliver concise messages for implementing cardiovascular prevention
4. Meditation practice may decrease risk for cardiovascular disease in teens
5. Meditation practice may decrease risk for cardiovascular disease in teens
6. Exercise program improved health of lung transplant patients and cut cardiovascular risk
7. Low steroid levels linked to increased risk of cardiovascular disease
8. Prostate cancer treatment regret is 52 percent higher in men with cardiovascular disease
9. Prevention is better than cure for killer cardiovascular disease
10. Increased cardiovascular risk in HIV-infected patients may relate to arterial inflammation
11. NIH launches trial to evaluate anti-inflammatory treatment for preventing heart attacks, strokes, and cardiovascular deaths
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... 08, 2016 , ... STAT courier is pleased to announce that due to ... they are expanding their presence in Dallas. One of the most exciting parts for ... jobs to the Dallas and Forth Worth market. STAT takes pride in treating their ...
(Date:12/8/2016)... ... December 08, 2016 , ... Dickinson ... from offices headquartered in Little Rock, has initiated a charity drive to provide ... National Foundation to End Senior Hunger, Arkansas ranks first in senior hunger statewide, ...
(Date:12/8/2016)... ... December 08, 2016 , ... The Compretta Insurance Agency, a family ... in and around the Hancock County area, is announcing the launch of a charity ... , The Hancock County Food Pantry has worked for more than 30 years to ...
(Date:12/7/2016)... , ... December 07, 2016 , ... ... the passage of the most comprehensive mental health systems reform legislation in more ... of the President, and the commitment of our elected officials to improving mental ...
(Date:12/7/2016)... , ... December 07, 2016 , ... ... women growing up with a schizophrenic mother in a unique, personal perspective through ... specializes in treating trauma and addictive disorders at her private psychotherapy practice. Sheri’s ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... DALLAS , Dec. 8, 2016 Dignitana, ... an exclusive partnership with Boa® Technology, creator of the ... fit cap for use with the DigniCap® scalp cooling ... Drug Administration in December 2015, and is the first ... The DigniCap® scalp cooling system features a patented ...
(Date:12/8/2016)... 2016  Avelas Biosciences, Inc., a clinical stage ... from diagnosis through treatment, today presented clinical trial ... study in breast cancer patients utilizing investigational drug ... Symposium. Jonathan Unkart , M.D., resident physician ... Health, delivered the presentation titled "Intraoperative tumor detection ...
(Date:12/8/2016)... FRANCISCO , Dec. 8, 2016 ... today announced that it has closed a $23 ... McKesson Ventures and OrbiMed. The company seeks to ... time physicians spend on mandated EHR documentation. The ... scribe service that frees doctors from 3 hours ...
Breaking Medicine Technology: