Navigation Links
Cardiovascular Institute: Unfolded protein response contributes to sudden death in heart failure
Date:12/2/2013

PROVIDENCE, R.I. A researcher at the Cardiovascular Institute (CVI) at Rhode Island, The Miriam and Newport hospitals has found a link to human heart failure that if blocked, may reduce the risk of sudden cardiac death. The paper, written by Samuel C. Dudley, M.D., Ph.D., chief of cardiology at the CVI, is published in the journal Circulation: Arrhythmia and Electrophysiology.

Sudden cardiac death (SCD) is an unexpected death caused by loss of heart function, or sudden cardiac arrest. It is the most common cause of natural death in the U.S., resulting in approximately 325,000 adult deaths in the U.S. each year.

The study found that the unfolded protein response (UPR), a condition usually associated with viral infections, diabetes and obesity, is activated in human heart failure and can increase the risk of sudden cardiac death. The UPR Is a cell defense system designed to shut down protein synthesis and respond when the cell makes defective or foreign proteins. This prevents cell death as a result of accumulation of a large number of defective or unwanted proteins. Previously, it was unknown that the UPR is also active in heart failure and may explain the loss of many useful proteins in this condition.

"Half of all patients who suffer from abnormal heart beats will die from heart failure," said Dudley, the study's principal investigator. "While we still don't know exactly what causes this electrical instability in the heart, we do know that it leads to abnormal heart beats and can increase the risk of sudden cardiac death."

Dudley continued, "This is the first time that the unfolded protein response has been implicated in sudden cardiac death. Therefore, if we can find a way to block the unfolded protein response, we are one step closer to finding a treatment to significantly reduce the risk of sudden cardiac death."

Sudden cardiac arrest, which can lead to SCD, is often confused with heart attack. Heart attacks occur when there is a blockage in one or more of the arteries to the heart, preventing the heart from receiving blood. Whereas sudden cardiac arrest occurs when the electrical system to the heart malfunctions and the heart beat suddenly becomes very irregular, and very fast, preventing blood from flowing to the brain and elsewhere in the body. This often results in a loss of consciousness, and eventually death if not treated quickly.


'/>"/>

Contact: Ellen Slingsby
eslingsby@lifespan.org
401-444-6421
Lifespan
Source:Eurekalert

Related medicine news :

1. Edoxaban effective in preventing stroke, reducing bleeding and cardiovascular death in patients with atrial fibrillation
2. Data show drug being tested to reduce cardiovascular events increased risk of heart attack
3. A Best Manuscript Award Goes to the Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai
4. Northern California Medical Associates (NCMA) Welcomes Jaime Molden, M.D. Cardiac Electrophysiologist to the NCMA Cardiovascular Services Team
5. RI Cardiovascular Institute to present 20+ abstracts at AHA annual Scientific Sessions
6. Researchers discover that the body clock may influence morning peak in adverse cardiovascular events
7. BCC Research Publishes a New Report On Global Markets for Cardiovascular Surgical Devices
8. Study finds testosterone therapy may reduce risk of cardiovascular disease
9. AGH Cardiovascular Team Explores Implantable Device Designed to Treat Congestive Heart Failure
10. Study strengthens link between low dietary fiber intake and increased cardiovascular risk
11. Global Cardiovascular Device Companies Surveying Market: Worldwide Industry Latest Market Share, Growth, Size,Trends, Strategy And Forecast Research Report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... ... , ... The Global Wellness Summit (GWS), an annual conference for ... wellness, travel, spa and beauty in Europe. The organization asked its partner experts in ... and researchers - to forecast where wellness is headed in Europe. Predictions range from ...
(Date:5/31/2016)... ... May 31, 2016 , ... Interest is on the ... tool and as an orthogonal tool for RNAi hit validation. A key reason may ... guide RNAs—allows rapid generation of CRISPR RNA (crRNA) collections in arrayed formats. , ...
(Date:5/31/2016)... ... , ... Dr. Charles A. Ditta attained his Doctor of Medical Dentistry Degree ... 1986, where he graduated in the top ten percentile of his class. Dr. Ditta ... He has been a member in good standing for thirty years in the American ...
(Date:5/30/2016)... ... May 30, 2016 , ... As the CDC relaxes its stance on traditional ... to keep their households lice free. , According to a May 26 article ... keep kids in the classroom despite the fact that they may be harboring an ...
(Date:5/29/2016)... ... ... Whole Health Supply is happy to announce the favorable reception of its ... new style of nail clipper has a wider jaw opening that is useful for ... actual handle is 2.5mm thick to accommodate the cutting force. This is the maximum ...
Breaking Medicine News(10 mins):
(Date:5/30/2016)... , May 30, 2016 ... H1 2016" market research report with comprehensive information ... with comparative analysis at various stages, therapeutics assessment ... of administration (RoA) and molecule type, along with ... It also reviews key players involved in the ...
(Date:5/27/2016)... 2016 Hutchison China MediTech ... on the highly lucrative global oncology and immunology ... potential first-in-class or best-in-class tyrosine kinase inhibitor (TKI) ... strategic partners. HCM,s profitable Chinese healthcare business continues ... expect progress of the mid-to-late-stage pipeline during 2016-17 ...
(Date:5/26/2016)... 2016 A key trend that ... emergence of new treatments. Cardax, a development stage life ... The therapy is expected to fulfil large unmet medical ... conducting studies to develop new treatments for osteoarthritis. One ... involved in osteoarthritis are being investigated, and early trials ...
Breaking Medicine Technology: