Navigation Links
Cardiovascular Institute: Unfolded protein response contributes to sudden death in heart failure
Date:12/2/2013

PROVIDENCE, R.I. A researcher at the Cardiovascular Institute (CVI) at Rhode Island, The Miriam and Newport hospitals has found a link to human heart failure that if blocked, may reduce the risk of sudden cardiac death. The paper, written by Samuel C. Dudley, M.D., Ph.D., chief of cardiology at the CVI, is published in the journal Circulation: Arrhythmia and Electrophysiology.

Sudden cardiac death (SCD) is an unexpected death caused by loss of heart function, or sudden cardiac arrest. It is the most common cause of natural death in the U.S., resulting in approximately 325,000 adult deaths in the U.S. each year.

The study found that the unfolded protein response (UPR), a condition usually associated with viral infections, diabetes and obesity, is activated in human heart failure and can increase the risk of sudden cardiac death. The UPR Is a cell defense system designed to shut down protein synthesis and respond when the cell makes defective or foreign proteins. This prevents cell death as a result of accumulation of a large number of defective or unwanted proteins. Previously, it was unknown that the UPR is also active in heart failure and may explain the loss of many useful proteins in this condition.

"Half of all patients who suffer from abnormal heart beats will die from heart failure," said Dudley, the study's principal investigator. "While we still don't know exactly what causes this electrical instability in the heart, we do know that it leads to abnormal heart beats and can increase the risk of sudden cardiac death."

Dudley continued, "This is the first time that the unfolded protein response has been implicated in sudden cardiac death. Therefore, if we can find a way to block the unfolded protein response, we are one step closer to finding a treatment to significantly reduce the risk of sudden cardiac death."

Sudden cardiac arrest, which can lead to SCD, is often confused with heart attack. Hear
'/>"/>

Contact: Ellen Slingsby
eslingsby@lifespan.org
401-444-6421
Lifespan
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Edoxaban effective in preventing stroke, reducing bleeding and cardiovascular death in patients with atrial fibrillation
2. Data show drug being tested to reduce cardiovascular events increased risk of heart attack
3. A Best Manuscript Award Goes to the Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai
4. Northern California Medical Associates (NCMA) Welcomes Jaime Molden, M.D. Cardiac Electrophysiologist to the NCMA Cardiovascular Services Team
5. RI Cardiovascular Institute to present 20+ abstracts at AHA annual Scientific Sessions
6. Researchers discover that the body clock may influence morning peak in adverse cardiovascular events
7. BCC Research Publishes a New Report On Global Markets for Cardiovascular Surgical Devices
8. Study finds testosterone therapy may reduce risk of cardiovascular disease
9. AGH Cardiovascular Team Explores Implantable Device Designed to Treat Congestive Heart Failure
10. Study strengthens link between low dietary fiber intake and increased cardiovascular risk
11. Global Cardiovascular Device Companies Surveying Market: Worldwide Industry Latest Market Share, Growth, Size,Trends, Strategy And Forecast Research Report
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2015)... NY and Greenwich, CT (PRWEB) , ... August ... ... (“Professional”), a Great Point Partners I, L.P. (“GPP”) portfolio company has acquired Premier ... Connecticut — incorporating it into its portfolio of state-of-the-art clinics. , “Our acquisition ...
(Date:8/1/2015)... ... August 01, 2015 , ... BeverlyD, owner and founder of BeverlyD Luxe Organic ... very first small business donation to kick off the campaign for healing and Well-Being. ... legacy includes a complete line of raw, organic hair care products, as well as ...
(Date:7/31/2015)... Santa Rosa, CA (PRWEB) , ... July 31, ... ... been posted by High Times magazine. What are the STASH awards? The ... celebrate advances made by the cannabis-cultivation community as well as tried-and-true products that ...
(Date:7/31/2015)... ... 2015 , ... The Honor Society of Nursing, Sigma Theta Tau International (STTI) ... (GAPFON) 20-21 July 2015 in San Juan, Puerto Rico. Key nurse leaders from Central ... Cassiani, Advisor, Nursing and Allied Health Personnel Development, Unit of Human Resources for Health, ...
(Date:7/31/2015)... ... ... Precision Aesthetics is New York’s only Thermage skin tightening pinnacle and black diamond award ... fat reduction in New York. Due to its unparalleled level of experience for ... patients travel to New York to get their non-surgical skin tightening and body shaping ...
Breaking Medicine News(10 mins):Health News:Professional Physical Therapy Now Largest Outpatient Physical Therapy Provider in Northeast With Acquisition of Premier Physical Therapy & Wellness 2Health News:March4thforWellBeing Foundation Kickoff 2Health News:The High Times S.T.A.S.H. Awards Are in, Guess Who Took Home the Prize for “Best Grow System” 2Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 2Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 3Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 4
... FORT WORTH, Texas, Nov. 11 Wound Management ... Management Technologies Division will search for partners to ... to develop opportunities within the International Biotechnology and ... developments concerning advisory board appointments, research affiliations, and ...
... FAIRFAX, Va.Catheter-directed therapy or catheter-directed thrombolysisan interventional radiology ... specially designed catheters to dissolve dangerous blood clots ... a first-line treatment option for massive pulmonary embolism, ... Vascular and Interventional Radiology . "Modern ...
... ... announces new research focusing on Employee Engagement, Revenue and the New Economy as kickoff ... ... 12, 2009 -- There is little else more pressing in business than the financial ...
... ... decades The American Red Cross is making available for sale to the ... and bound journals, antique uniforms (1925 – 1941), flags, vintage ... a model train, photographs (including those of the founder Clara Barton, past ...
... The Quigley Corporation, (Nasdaq: QGLY) , ... a conference call in which Ted Karkus, Chairman and CEO, will ... results and Q&A. , The conference call will be ... www.quigleyco.com ), at 11:00 AM (ET) on Thursday, November 12, ...
... , LONDON, Nov. 11 The healthcare market is ... the global economic slowdown. Costs for healthcare are reaching ... exception. Market players in this industry have been faced ... technological advancements in hardware, high replacement costs, exchange rates ...
Cached Medicine News:Health News:OTCBB-WNDM Announces Activation of BioPharma Division to Solicit Technology and Development Partners 2Health News:OTCBB-WNDM Announces Activation of BioPharma Division to Solicit Technology and Development Partners 3Health News:When seconds count: Interventional radiology treatment for pulmonary embolism saves lives 2Health News:When seconds count: Interventional radiology treatment for pulmonary embolism saves lives 3Health News:Performance Connections International Announces New Research Focusing on the Impact of Employee Engagement in the New Economy 2Health News:Performance Connections International Announces New Research Focusing on the Impact of Employee Engagement in the New Economy 3Health News:American Red Cross Auctions Historical Artifacts Through OLS Trading, Inc 2Health News:American Red Cross Auctions Historical Artifacts Through OLS Trading, Inc 3Health News:The Quigley Corporation to Host Conference Call to Review Third Quarter Results and Provide Company Update 2Health News:Frost & Sullivan to Hold Analyst Briefing on the European Neurophysiological Monitoring Market, the Golden Standard in Patient Safety 2Health News:Frost & Sullivan to Hold Analyst Briefing on the European Neurophysiological Monitoring Market, the Golden Standard in Patient Safety 3
(Date:7/31/2015)... India , July 31, 2015 ... CRM solutions for video, data and cloud computing ... with a leading pharma giant for Internet of ... different IoT applications offered on subscription model. ... Pharma giant is striving for business innovations ...
(Date:7/30/2015)... July 30, 2015  ResMed Inc. (NYSE: RMD ... 30, 2015.  Revenue for the quarter was $453.1 million, ... June 30, 2014 (a 17 percent increase on a ... with the quarter ended June 30, 2014.  Diluted earnings ... the quarter ended June 30, 2014.  ...
(Date:7/30/2015)... BOTHELL, Wash. and VANCOUVER ... OGXI ) announced today that it will report ... 13, 2015. Company management will host a conference call ... provide an overview of financial results, clinical development programs ... access the webcast, log on to the Investor Relations ...
Breaking Medicine Technology:Magnaquest Signs a POC With a Leading Pharma Giant in Europe to Manage Subscription Management and Billing for Internet of Things (IoT) 2ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 2ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 3ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 4ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 5ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 6ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 7ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 8ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 9ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 10ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 11ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 12ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 13ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 14ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 15ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 16
... Denmark , Feb. 1 LEO Pharma ... mebutate) Gel, the company,s lead candidate for the topical treatment ... primary clinical endpoint of complete clearance of AK lesions in ... AK support results from the earlier REGION-I trial, a study ...
... Ill. and CASTRES, France , Feb. 1 ... licensing agreement with Pierre Fabre SA to develop and commercialize h224G11, ... (CIPF) in France and targeting the cMet receptor for ... progression of a range of solid tumors including, prostate, lung and ...
Cached Medicine Technology:LEO Pharma's PEP005 Meets Primary Endpoint in Phase III Trial for Pre-Cancerous Skin Condition 2LEO Pharma's PEP005 Meets Primary Endpoint in Phase III Trial for Pre-Cancerous Skin Condition 3Abbott and Pierre Fabre SA Announce Collaboration to Research and Develop Novel Treatments for Cancer 2Abbott and Pierre Fabre SA Announce Collaboration to Research and Develop Novel Treatments for Cancer 3
The SF-3000 automated hematology analyzer can provide accurate and precise 23-parameter hematolgy results including a fully automated WBC 5-part differential from a compact space-save design....
Ac.T 5diff CP allows quick and direct access to a closed sample tubea feature that reduces manual sample handling, saves time and enhances safety by eliminating operators exposure to biohazards....
... 755 simplifies and automates high-volume ... automation and advanced technologies into ... accurate results every time. Plus, ... quality with its slide-on-slide smearing ...
... The CX31 continue ... of the CH2 microscopes ... arenas, now with UIS ... models improve all-around performance ...
Medicine Products: