Navigation Links
Cardiologists identify mechanism that makes heart disease worse in diabetics
Date:3/1/2012

DALLAS -- UT Southwestern Medical Center cardiologists have uncovered how a specific protein's previously unsuspected role contributes to the deterioration of heart muscle in patients with diabetes. Investigators in the mouse study also have found a way to reverse the damage caused by this protein.

The new research, available online and published in the March 1 issue of the Journal of Clinical Investigation, was carried out in the laboratory of Dr. Joseph Hill, director of the Harry S. Moss Heart Center at UT Southwestern.

"If we can protect the heart of diabetic patients, it would be a significant breakthrough," said Dr. Hill, the study's senior author who also serves as chief of cardiology at the medical center. "These are fundamental research findings that can be applied to a patient's bedside."

Cardiovascular disease is the leading cause of illness and death in patients with diabetes, which affects more than 180 million people around the world, according to the American Heart Association. Diabetes puts additional stress on the heart above and beyond that provoked by risk factors such as high blood pressure or coronary artery disease, Dr. Hill said.

"Elevated glucose and the insulin-resistant diabetic state are both toxic to the heart," he said.

Dr. Hill and his colleagues in this study were able to maintain heart function in mice exposed to a high fat diet by inactivating a protein called FoxO1. Previous investigations from Dr. Hill's laboratory demonstrated that FoxO proteins, a class of proteins that govern gene expression and regulate cell size, viability and metabolism, are tightly linked to the development of heart disease in mice with type 2 diabetes.

"If you eliminate FoxO1, the heart is protected from the stress of diabetes and continues to function normally," Dr. Hill said. "If we can prevent FoxO1 from being overactive, then there is a chance that we can protect the hearts of patients with diabetes."


'/>"/>
Contact: Robin Russell
robin.russell@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Related medicine news :

1. EHJ paper underlines need for improved links between cardiologists and psychiatrists
2. Beyond pills: Cardiologists examine alternatives to halt high blood pressure
3. Cardiologists Often Miss Heart Defects in Young Athletes: Study
4. Pediatric cardiologists not always accurate in interpreting ECG results for young athletes
5. NYU Langone Medical Center cardiologists present at ACC 60th Annual Scientific Session
6. University Hospitals Case Medical Center cardiologists discover cancer risks in blood pressure meds
7. New research shows cardiologists can quickly detect significant coronary artery disease using a non-invasive simple, short respiratory stress test
8. Cardiologists Comment on Aspirin Versus Resveratrol
9. Gladstone scientists identify genetic mechanism linked to congenital heart disease
10. University of Granada researchers identify changes in tumor cells that lead to metastasis
11. Cell death researchers identify new Achilles heel in acute myeloid leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cardiologists identify mechanism  that makes heart disease worse in diabetics
(Date:6/27/2016)... ... 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to Best ... individuals in the United States and Canada wear eyeglasses. Once considered to be a ... and make a fashion statement. Even celebrities use glasses as a way of creating ...
(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer ... through a fitness app. The fitness app plans to fix the two major problems leading ... a one size fits all type program , They don’t eliminate all the ...
(Date:6/25/2016)... ... ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize each ... Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into hand ... select a ProHand generator and drag it above media or text in the Final ...
(Date:6/25/2016)... ... 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s a ... the bar too high can result in disappointment, perhaps even self-loathing. However, those who ... , Research from PsychTests.com reveals that behind the tendency to set ...
(Date:6/24/2016)... Texas (PRWEB) , ... June 24, 2016 , ... ... International Conference and Scientific Sessions in Dallas that it will receive two significant ... of the grants came as PHA marked its 25th anniversary by recognizing patients, ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 ... announced the addition of the " Global Markets ... This report focuses ... an updated review, including its applications in various applications. ... market, which includes three main industries: pharmaceutical and biotechnology, ...
(Date:6/24/2016)... 2016 The Academy of Managed Care Pharmacy ... that would allow biopharmaceutical companies to more easily share ... formulary and coverage decisions, a move that addresses the ... The recommendations address restrictions in the sharing ... drug label, a prohibition that hinders decision makers from ...
(Date:6/24/2016)... Mass. and SAN CLEMENTE, Calif. , ... California -based mobile pulmonary function testing company, is now able ... PFT devices developed by ndd Medical Technologies , Inc. ... testing done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® ... , can get any needed testing done in the comfort ...
Breaking Medicine Technology: