Navigation Links
Cardiologists identify mechanism that makes heart disease worse in diabetics
Date:3/1/2012

DALLAS -- UT Southwestern Medical Center cardiologists have uncovered how a specific protein's previously unsuspected role contributes to the deterioration of heart muscle in patients with diabetes. Investigators in the mouse study also have found a way to reverse the damage caused by this protein.

The new research, available online and published in the March 1 issue of the Journal of Clinical Investigation, was carried out in the laboratory of Dr. Joseph Hill, director of the Harry S. Moss Heart Center at UT Southwestern.

"If we can protect the heart of diabetic patients, it would be a significant breakthrough," said Dr. Hill, the study's senior author who also serves as chief of cardiology at the medical center. "These are fundamental research findings that can be applied to a patient's bedside."

Cardiovascular disease is the leading cause of illness and death in patients with diabetes, which affects more than 180 million people around the world, according to the American Heart Association. Diabetes puts additional stress on the heart above and beyond that provoked by risk factors such as high blood pressure or coronary artery disease, Dr. Hill said.

"Elevated glucose and the insulin-resistant diabetic state are both toxic to the heart," he said.

Dr. Hill and his colleagues in this study were able to maintain heart function in mice exposed to a high fat diet by inactivating a protein called FoxO1. Previous investigations from Dr. Hill's laboratory demonstrated that FoxO proteins, a class of proteins that govern gene expression and regulate cell size, viability and metabolism, are tightly linked to the development of heart disease in mice with type 2 diabetes.

"If you eliminate FoxO1, the heart is protected from the stress of diabetes and continues to function normally," Dr. Hill said. "If we can prevent FoxO1 from being overactive, then there is a chance that we can protect the hearts of patients with diabetes."


'/>"/>
Contact: Robin Russell
robin.russell@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Related medicine news :

1. EHJ paper underlines need for improved links between cardiologists and psychiatrists
2. Beyond pills: Cardiologists examine alternatives to halt high blood pressure
3. Cardiologists Often Miss Heart Defects in Young Athletes: Study
4. Pediatric cardiologists not always accurate in interpreting ECG results for young athletes
5. NYU Langone Medical Center cardiologists present at ACC 60th Annual Scientific Session
6. University Hospitals Case Medical Center cardiologists discover cancer risks in blood pressure meds
7. New research shows cardiologists can quickly detect significant coronary artery disease using a non-invasive simple, short respiratory stress test
8. Cardiologists Comment on Aspirin Versus Resveratrol
9. Gladstone scientists identify genetic mechanism linked to congenital heart disease
10. University of Granada researchers identify changes in tumor cells that lead to metastasis
11. Cell death researchers identify new Achilles heel in acute myeloid leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cardiologists identify mechanism  that makes heart disease worse in diabetics
(Date:2/17/2017)... ... February 17, 2017 , ... Access ... & Exhibition in Orlando, Fla., February 19-23. Visitors to the company’s booth (#1778) ... widely used electronic patient signatures solution in healthcare . , Since it ...
(Date:2/17/2017)... ... February 17, 2017 , ... Pharmica Consulting attended CHI's 8th ... of clinical trial planning and management. Pharmica discussed the importance of effective project ... attendees stopping by Pharmica’s booth were able to demo its cloud-based Resource ...
(Date:2/17/2017)... (PRWEB) , ... February 17, 2017 , ... Like most ... reduce readmissions. Driven in large part by the Hospital Readmission Reduction Program (HRRP), the ... a key focus area for hospitals across the nation. While many providers are struggling ...
(Date:2/17/2017)... ... February 17, 2017 , ... Dillon Ruxton Insurance, a Florida-based ... owners in the greater Fort Lauderdale metropolitan region, is embarking on a cooperative ... 30 years, LifeNet 4 Families has provided a broad range of food provision ...
(Date:2/16/2017)... , ... February 17, 2017 , ... Teaching nursing care ... program, now in development. ACE.P (pediatrics) is being created with the support of the ... of Vulnerable Populations , ACE.P will address what has been identified as a critical ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... ST. LOUIS , Feb. 17, 2017   ... hospitals, has announced a new partnership with Engage ... the United States . FormFast will serve ... part of Engage,s implementations with MEDITECH .  ... that provides essential functionality to complement and enhance the ...
(Date:2/16/2017)... Pa. , Feb. 16, 2017 Absorption ... biologics, and medical devices, is pleased to announce that ... has been selected as a winner of the 2017 ... SmartCEO Magazine and recognizes driven executives for their ... work ethic. The awards ceremony and celebration is on ...
(Date:2/16/2017)... , Feb. 16, 2017  Aralez Pharmaceuticals Inc. (NASDAQ: ... pharmaceutical company, today announced that executive management will participate ... be held February 22-23, 2017. Adrian Adams , ... Company at 1:35 p.m. local time on Wednesday, February ... archive for the event may be accessed from the ...
Breaking Medicine Technology: