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Cardiologist Praises Latest Resveratrol/Red Wine Research
Date:6/24/2008

Supplementing with resveratrol at low doses is a "likely robust intervention in the retardation of cardiac aging," according to the study's authors.

Genetic Prevention of Brain and Skeletal Muscle Aging by Resveratrol and CR

CR and resveratrol also opposed genetic aging of brain and skeletal muscle, though to a lesser extent than heart aging. Aging resulted in the change of 515 skeletal muscle genes; 26% were opposed by CR and resveratrol. In the brain (neocortex), CR and resveratrol inhibited 19 and 13%, respectively, of the 505 highly significant age-related changes.

Mechanisms of Action of Low-Dose Resveratrol

Low-dose resveratrol appears to enhance health by different pathways than high-dose resveratrol. Low-dose resveratrol did not enhance health by altering the well-known factors postulated to impact aging: IGF-1, insulin, SIRT1, oxidative stress.

The mechanism of action of low-dose resveratrol appears to be at the genetic chromosome (chromatin) level. Other mechanisms of action of low-dose resveratrol may be through stimulation of AMP kinase and nitric oxide synthase activity.

Resveratrol and Dietary Supplements for Anti-Aging

"This study confirms that dietary resveratrol can improve genetic performance in old age of vitally important organs. It's a tremendous breakthrough! You can improve your genetic performance as you get older by starving yourself, or you can take a glass of red wine or a resveratrol supplement," concludes Dr. Gruss.

In his book, Dr. Gruss recommends dietary supplements to address the four factors of aging: genetic breakdown, oxidation, inflammation, and reduced mitochondrial energy.

"I prefer alpha lipoic acid and oligomeric proanthocyanins (OPCs) from grape skin and seed as antioxidants; acetyl L-carnitine as a mitochondrial energy booster; and quercetin to reduce inflammation. Resveratrol is obviously the first choice for genetic support as you age," says Dr. Gruss.


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SOURCE Renaissance Health
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