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Cardiologist Praises Latest Resveratrol/Red Wine Research
Date:6/24/2008

) and invertebrate (yeast, roundworms, fruit flies) life forms.

Resveratrol Inhibits Aging Genes

Prior to the resveratrol research, the only known method to extend life-span was a near-starvation diet. Caloric restriction (CR) has been found to retard aging and physiological decline. CR is so restrictive that it is not practical for humans as a way of prolonging life-span.

In the study, researchers fed one group of mice a control diet, one group a calorie restricted diet, and one a low dose of resveratrol (equivalent to about 350mg a day for humans). They found "a striking transcriptional overlap of CR and resveratrol in heart, skeletal muscle and brain."

"The genetic profile in brain, heart and skeletal muscle tissue of the mice on CR and resveratrol were nearly identical as they aged. They were far healthier than the control mice," explains Dr. Gruss.

Genetic and Functional Prevention of Cardiac Aging by Resveratrol and CR

Heart disease is the number one killer of Americans. According to the study, cardiac function declines with age in both mice and humans.

"The most exciting conclusion from this study is that CR and resveratrol almost completely prevented the age-related decrease in an important parameter of heart health-the myocardial performance index, an overall assessment of cardiac function," says Dr. Gruss. "Researchers concluded that resveratrol prevented cardiac aging at both the genetic and functional levels."

Comparing young and old mice fed the control diet, there were 1,029 genes that changed as the mice got older. CR opposed the changes in 921 (90%) of the age-related genes, with 536 of the genes making a significant difference. Resveratrol opposed 947 (92%) of age-related changes as the mice got older, with 522 of the genes representing highly significant differences between the old control and old resveratrol groups.

Changes in genes are considered one of the major biomarkers of aging.
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SOURCE Renaissance Health
Copyright©2008 PR Newswire.
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