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Cardiogenesis Announces Preliminary Results Combining TMR + Platelet Rich Plasma (PRP)
Date:6/18/2008

l present not only reinforce the clinical utility of TMR, but also suggests that our TMR system can enhance the effectiveness of a biologic agent." Lanigan added, "Dr. Wehberg utilized the FDA approved Cardiogenesis TMR System along with readily available PRP as combination therapy in his series with favorable results. Earlier this month, at the 10th annual meeting of the International Society of Minimally Invasive Cardiothoracic Surgeons (ISMICS) meeting in Boston, Dr. Guillermo Reyes (La Princesa University Hospital, Madrid) reported on the use of the Company's PHOENIX System that enables a combination TMR and biologics delivery in a single handpiece. Dr. Reyes reported the combination of TMR with bone marrow derived stem cells had demonstrated an improvement in angina class and reduction in the use of nitrates for the treated patients. These two reports demonstrate the clinical potential for TMR to enhance the effect of biologic substances through their precise delivery into the stimulated tissue border zone around the holmium: YAG TMR channels. Our focus is to build on this early work and provide clinicians with effective tools to treat the large patient population suffering from refractory angina by means of TMR and TMR plus biologics."

About Cardiogenesis Corporation

Cardiogenesis is a medical device company specializing in the treatment of cardiovascular disease and is a leader in devices that stimulate cardiac angiogenesis. The company's market leading holmium:YAG laser system and disposable fiber-optic accessories are used to perform a FDA-cleared surgical procedure known as Transmyocardial Revascularization (TMR) to treat patients suffering from angina. Surgical products and accessories for the Cardiogenesis TMR procedure, which are marketed in the U.S. and around the world, have been shown to reduce angina and improve the quality of life in patients with coronary artery disease.

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