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Cardiff scientists bid to develop anthrax vaccine to counteract world bioterrorism threat
Date:9/17/2012

A team of Cardiff University scientists is leading new research to develop a vaccine against anthrax to help counteract the threat of bioterrorism.

Working with scientists from the Republic of Georgia, Turkey and the USA, Professor Les Baillie from Cardiff University's School of Pharmacy and Pharmaceutical Sciences is leading a NATO project to tackle the potential misuse of anthrax.

"Currently the majority of the world's population is susceptible to infection with Bacillus anthracis the bacterium which causes anthrax," according to Professor Baillie, who leads the multi-national research collaboration.

"The US postal attacks in 2001 highlighted the vulnerability of civilian populations and brought home the need to develop effective, rapid, robust medical countermeasures to combat the threat posed by terrorist use of this organism," he added.

It is the growing concern over the threat posed by bioterrorism that has prompted world authorities like NATO through its Science for Peace and Security Programme to support efforts to develop more effective vaccines and medical countermeasures.

Efforts have so far been hampered by the fact that cases of naturally acquired human infection are rare in NATO countries. As a consequence, researchers have been forced to employ animal models to develop new vaccines.

The problem with this approach is the immune responses of animals and humans differ and as a consequence human clinical trials represent an essential element in confirming the efficacy of any new vaccine.

Such trials require access to several thousand volunteers at risk of infection and as such would be almost impossible to perform in Western Europe or the US.

In contrast anthrax represents a significant disease of animals and humans in the Cacuses and Central Asia. For this reason researchers from the UK and US have joined with colleagues from Turkey and the former So
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Contact: Professor Les Baillie
baillieL@cf.ac.uk
029-208-75535
Cardiff University
Source:Eurekalert

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