Navigation Links
Cardiac stent patients with diabetes may benefit from drug that counteracts the effects of leptin
Date:12/17/2008

NEW YORK (Dec. 17, 2008) The naturally high levels of leptin in diabetic patients may reduce the effectiveness of drug-eluting stents used to treat heart blockages, but using a chemical that differs from the one commonly used to coat stents could counteract this effect.

The work by researchers at Columbia University Medical Center could potentially improve outcomes in diabetics who get stents, they say. Though drug-eluting stents reduce the chance coronary arteries will become blocked again, clogged stents are still more common in diabetic patients than in the general population. About 250,000 Americans with diabetes receive drug-eluting stents every year.

A hormone commonly associated with obesity leptin may be partly responsible, according to recently published research in the Proceedings of the National Academy of Sciences by Andrew Marks, M.D., chair of physiology & cellular biophysics and Clyde and Helen Wu Professor of Molecular Cardiology, and Steven Marx, M.D., associate professor of medicine and pharmacology. The study found that leptin, at the elevated concentrations frequently found in patients with diabetes, stimulates the growth of cells responsible for clogging the stents in mice, even in the presence of sirolimus, a drug used in many stents to prevent cell growth.

The same mouse study also identified a drug a PI3kinase inhibitor that counteracts the effect of leptin on cell growth. If added to current drug-eluting stents, such a drug may further reduce reclogging rates in patients with diabetes to the single digit rates seen in other patients. An improved stent could significantly reduce the numbers of patients who eventually need coronary bypass surgery after their stents become severely obstructed.


'/>"/>

Contact: Alex Lyda
mal2133@columbia.edu
212-305-0820
Columbia University Medical Center
Source:Eurekalert

Page: 1

Related medicine news :

1. Cost of Hospital Cardiac Care on the Rise
2. Study Asks: Are Physicians Overusing an Invasive Cardiac Treatment?
3. Hormone therapy for prostate cancer does not appear to increase cardiac deaths
4. ICON Medical Imaging Launches New Cardiac Echocardiography Analysis Software
5. Cardium Reports on New York Citys Adoption of Therapeutic Cooling Protocols for Cardiac Arrest Patients
6. Lung Disease Tied to Increased Risk for Cardiac Events
7. AGA Medical Receives European CE Mark Approval for AMPLATZER(R) Cardiac Plug
8. Another Study Warns of Risk From Cardiac Surgery Drug
9. Radiological Society of North America research: Cancer risk from cardiac CT overstated
10. Risk of death may be higher with drug commonly used during cardiac surgery
11. Large study illustrates cardiac CT can effectively assess coronary artery disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/29/2015)... , ... June 30, 2015 , ... ... set of revised Guidelines for Neuro Musculoskeletal Thermography and Sympathetic Skin Response Studies.* ... Guidelines that were first published in 2006, are intended to aid physicians and ...
(Date:6/29/2015)... ... June 29, 2015 , ... Healthpointe, one of ... John A. Mitamura, MD., PhD into their world-class multidisciplinary team of physicians and ... Long Beach , Irwindale and La Tijera-Los Angeles. , Orthopedic surgeons of ...
(Date:6/29/2015)... ... , ... Mediaplanet has released the first edition of “Heart ... glossy, full-color special section hit newsstands Friday, June 26th, and was distributed within ... with an estimated readership of 1.3 million. The digital component is being distributed ...
(Date:6/29/2015)... YORK, NEW YORK (PRWEB) , ... June 29, ... ... sleep apnea (OSA) is now being offered at NewYork-Presbyterian/Weill Cornell Medical Center. The ... Drug Administration and is an alternative to continuous positive airway pressure (CPAP), the ...
(Date:6/29/2015)... ... June 29, 2015 , ... National HealthCare Associates ... customer service for the 40-center nursing home group. Sixteen of their centers were ... the United States in one or more customer service areas. Those centers received ...
Breaking Medicine News(10 mins):Health News:American Academy of Thermology Publishes Revised 2015 Guidelines for Neuro-Musculoskeletal Thermography and Sympathetic Skin Response Studies 2Health News:American Academy of Thermology Publishes Revised 2015 Guidelines for Neuro-Musculoskeletal Thermography and Sympathetic Skin Response Studies 3Health News:Renowned Orthopedic and Spine Surgeon Joins Healthpointe in Long Beach 2Health News:Renowned Orthopedic and Spine Surgeon Joins Healthpointe in Long Beach 3Health News:Mediaplanet partners with USA TODAY and Kris Letang to raise awareness about the risk of heart attack and stroke 2Health News:NewYork-Presbyterian/Weill Cornell Medical Center Is First in New York to Offer New Alternative Treatment for Sleep Apnea 2Health News:NewYork-Presbyterian/Weill Cornell Medical Center Is First in New York to Offer New Alternative Treatment for Sleep Apnea 3Health News:NewYork-Presbyterian/Weill Cornell Medical Center Is First in New York to Offer New Alternative Treatment for Sleep Apnea 4Health News:National HealthCare Centers Receive 'Customer Experience Awards' 2Health News:National HealthCare Centers Receive 'Customer Experience Awards' 3Health News:National HealthCare Centers Receive 'Customer Experience Awards' 4
... Foundation site trends indicating measles risk remains highWASHINGTON, ... states - California, Pennsylvania, Maryland and Iowa - ... children living in the United States as well ... of the disease.(Logo: http://www.newscom.com/cgi-bin/prnh/20090108/RedCrossLOGO ...
... disease, experts say , , FRIDAY, April 17 (HealthDay News) -- ... (PTU) in children has been endorsed by the Endocrine Society. ... 9 New England Journal of Medicine , two experts ... and should no longer be used as a first-line treatment ...
... The following statement may be attributed to Amy ... Research: "We are pleased that the National Institutes of ... of creating federal guidelines to remove restrictions on embryonic ... great promise, today,s draft guidelines that would allow federal ...
... makes prevention more difficult, study finds, , , FRIDAY, April ... commit suicide have been diagnosed with a mental disorder. ... death certificates list mental disorder as a contributing factor, ... it more difficult for health-care policymakers to create prevention ...
... the United States Great Depression of 1929 has the ... and well-being across the parameters of occupational, spiritual, emotional, ... pace, people are at risk for suffering lowered self ... Miami,s St. Thomas University Counseling Programs - ...
... Offers SolutionMURFREESBORO, Tenn., April 17 Medication mistakes at ... to a recent national study, and the need for ... to Shane Reeves, D. Pharm and co-owner of Reeves-Sain.Reeves ... system of bottles to a clearer, more easily managed ...
Cached Medicine News:Health News:U.S. Measles Outbreaks Highlight Global Need 2Health News:Drug May Be Dangerous for Kids With Graves' Disease 2Health News:Death Certificates Incomplete for Suicide Victims 2Health News:Good News for Tough Times: Small, Private University Responds to Today's Economic Challenges 2Health News:Medication Mismanagement Is a Growing Danger 2
(Date:6/29/2015)... SAN FRANCISCO , June 29, 2015 ... 47.54 billion by 2020, according to a new study by Grand ... II diabetes and the presence of high unmet needs in emerging ... China are expected to be two of the most ... lifestyle induced diseases such as obesity and growing global geriatric population ...
(Date:6/29/2015)... CITY, Mo. , June 29, 2015  Missouri ... the 2015 first quarter data from the state,s real-time, ... (NPLEx). States across the United ... Missouri one of 31 across the country ... attempted pseudoephedrine (PSE) purchases at the point of sale.  ...
(Date:6/29/2015)... KING OF PRUSSIA, Pa. , June 29, 2015 ... Alsharabati, MD, University of Alabama at Birmingham, ... 2015 Interlaken Leadership Award for ... global awards program provides monetary grants and/or product supply ... potential role of immunoglobulin (Ig) therapy in the treatment ...
Breaking Medicine Technology:Insulin Market To Reach $47.54 Billion By 2020: Grand View Research, Inc. 2Insulin Market To Reach $47.54 Billion By 2020: Grand View Research, Inc. 3Insulin Market To Reach $47.54 Billion By 2020: Grand View Research, Inc. 4CSL Behring Announces the 2015 Interlaken Leadership Awards Recipient 2CSL Behring Announces the 2015 Interlaken Leadership Awards Recipient 3
... 5, 2011 In its April issue, published this ... magazine has announced the winners of the fourteenth annual ... (Logo:  https://photos.prnewswire.com/prnh/20101214/LA16070LOGO) Sponsored by MD+DI ... the premier awards program for the medical technology community. ...
... April 5, 2011 RESMED INC. (NYSE: RMD ... will release its results for the third quarter and nine ... press release with ResMed,s results will be issued after 1:00 ... call and webcast to review its results, market trends, and ...
Cached Medicine Technology:37 Innovative Products Win Medical Design Excellence Awards 237 Innovative Products Win Medical Design Excellence Awards 337 Innovative Products Win Medical Design Excellence Awards 4ResMed Announces Conference Call and Webcast to Discuss Third Quarter 2011 Results 2
Dolwick-Reich Condyle periosteal elevator, 17.5 cm, 7"....
Molt periosteal elevator #9, 18.5 cm, 7-1/4"....
Obwegeser periosteal elevator, angled, 9 mm, 20 cm, 8"....
... Deformity System unites the clinical experience ... and Isola with revolutionary technology developed ... unsurpassed versatility, simplicity and security. Frontier ... versatility for treating a deformity from ...
Medicine Products: