Navigation Links
Cardiac effects associated with breast cancer treatment appear lower with dose-dense chemotherapy
Date:3/10/2008

NEW YORK, MARCH 6, 2008 A new pilot study by investigators at Memorial Sloan-Kettering Cancer Center (MSKCC) found that breast cancer patients can be treated safely with a dose-dense regimen of standard chemotherapy agents and the antibody trastuzumab (Herceptin), a drug that has previously been shown to cause cardiac toxicity. While previous reports evaluating the cardiac effects of breast cancer treatments including trastuzumab and anthracyclines have shown an acceptable safety margin, the new study demonstrates an even lower risk of cardiac toxicity when standard doses of these drugs are administered more frequently over time a treatment plan called dose-dense, which has previously been shown to be a more effective anti-cancer approach.

The researchers used a dose-dense regimen of doxorubicin (Adriamycin) and cyclophosphamide (Cytoxan or Neosar) followed by paclitaxel (Taxol) and found that the regimen when given every two weeks instead of three pairs safely with trastuzumab, a drug that is used to treat breast cancer in women whose tumors contain the protein receptor called HER2.

According to the findings, only 1.4 percent (one patient) of the 70 early-stage breast cancer patients treated with this regimen experienced congestive heart failure after 28 months of follow-up. This rate of cardiac toxicity is lower than the 4 percent threshold that is generally considered acceptable, and still lower than what was found in larger, previously published trials evaluating conventionally scheduled treatment with the use of trastuzumab.

The studys authors concluded that this dose-dense regimen combined with trastuzumab is a safe and effective way to treat women with early-stage HER2-positive breast cancer in the adjuvant setting and there is no need to forgo the use of this regimen because trastuzumab is also being administered.


'/>"/>

Contact: Esther Napolitano
napolite@mskcc.org
212-639-3139
Memorial Sloan-Kettering Cancer Center
Source:Eurekalert

Page: 1

Related medicine news :

1. Moderate alcohol consumption in middle age can lower cardiac risk
2. CardiacQA Surpasses 20,000 Client Generated Nuclear Cardiology Reports
3. Cardiac Science Reports Record Fourth Quarter and Full Year 2007 Results
4. Boston Scientific Announces First European Implants of New Devices to Treat Heart Failure and Sudden Cardiac Death
5. Cardiac Science Corporation Selects Colubris Networks Wireless Solution for its Portable Electrocardiograph
6. $4 million award to improve detection of acute kidney injury after cardiac surgery
7. Cardiac Science to Present at the Roth Capital Partners 20th Annual Growth Stock Conference
8. Drug Combo Tied to Kidney Risk With Some Cardiac Surgeries
9. Diagnostic Centers of America Retains NewsMark Public Relations to Showcase Its Rise as Only Medical Facility in South Florida With Worlds Most Advanced Cardiac Scanner
10. Gene predicts heart attack response and cardiac damage
11. Delray Beach Mayor Commemorates Diagnostic Centers of America (DCA) $2 Million Purchase from Siemens to Become Only Medical Facility in South Florida with Worlds Most Advanced Cardiac Scanner.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/13/2017)... ... ... With the increasing public preference for chemical-free personal care ... for customers who have grown more conscious about maintaining their health and wellness. ... products, Moody Zook Chief Executive Officer Nate Ginsburg explained their company’s decision to ...
(Date:1/13/2017)... ... 13, 2017 , ... An inventor from Virginia Beach, Va., is always on ... to diversify my outfits, so he decided to design something that enhances the look ... appearance of a belt to allow for quick, easy changing of its look. This ...
(Date:1/13/2017)... ... January 13, 2017 , ... "We wanted to create a ... said one of two inventors from Virginia Beach, Va. , They created a prototype ... , The accessories allow braces to be customized to suit personal tastes. They ...
(Date:1/13/2017)... ... January 13, 2017 , ... On January 11th, ... Cokato, MN, with the official send-off from Orchestra Hall in Minneapolis on Saturday, ... Minnesota Orchestra’s Music Director, leading the official launch of the sauna. After leaving ...
(Date:1/13/2017)... , ... January 13, 2017 , ... ... the world’s first and most comprehensive franchise ranking. Recognized by entrepreneurs and franchisors ... 129 for its exceptional performance in areas including financial strength and stability, growth ...
Breaking Medicine News(10 mins):
(Date:1/13/2017)... , Jan. 12, 2017   JDRF ... diabetes (T1D) research, is pleased to announce that ... the Centers for Medicare & Medicaid Services (CMS) ... by the FDA for use in making diabetes ... step toward making them eligible for coverage under ...
(Date:1/13/2017)... YORK , Jan. 12, 2017  Rosen Law ... filing of a class action lawsuit on behalf of ... ALXN ) from February 10, 2014 through November 9, ... recover damages for Alexion investors under the federal securities ... go to http://rosenlegal.com/cases-991.html or call Phillip ...
(Date:1/13/2017)... 2017  Biologics Prescribers Collaborative (BPC) applauds ... for issuing final guidance calling for distinguishable ... is an important win for patients and ... pharmacovigilance, patient safety and transparency. ... FDA, we remain concerned with "random" suffixes called for ...
Breaking Medicine Technology: