Navigation Links
Carbon monoxide counteracts one side-effect of an anti-cancer drug
Date:11/21/2007

Doxorubicin (DOX) is a red-colored anticancer drug that carries serious side effects for the heart, including cardiac muscle deterioration (cardiomyopathy) and scar tissue accumulation in the heart (fibrosis). These cardio-toxic effects are due to inhibition by DOX of mitochondrial biogenesis, a term used to describe cellular energy generation. In a new study by Claude Piantadosi and his colleagues at Duke University Medical Center, mitochondrial biogenesis was recovered in DOX-treated rodents by either inhalation of carbon monoxide (CO) or overexpression of the protein HO-1.

Mitochondrial biogenesis is known to depend on the presence of CO and HO, which promote energy production and defend the cell from injury. In mice treated with DOX, mitochondrial biogenesis in the heart was suppressed, resulting in heart cell death, thinning and dilation of the heart wall, and fibrosis. However, periodic inhalation of CO by DOX-treated mice restored mitochondrial biogenesis and averted cardiomyopathy. Likewise, overexpression of HO-1 in DOX-treated rat cardiac cells reduced mitochondrial DNA damage and subsequent cell death. The authors therefore suggested that protecting mitochondrial biogenesis in cancer patients treated with DOX might reduce the cardio-toxic side effects of the drug.


'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related medicine news :

1. National Association of EMS Educators (NAEMSE) Recommends Screening for Carbon Monoxide Poisoning
2. New study may explain Vioxx side-effects
3. Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
4. Discovery of widespread tumor growth gene holds promise for effective anti-cancer treatment
5. Aida Granted Additional Anti-Cancer Patent
6. A Chinese medicine compound has satisfactory anti-cancer effects on hepatocellular carcinoma
7. Telomerase enzyme structure provides significant new target for anti-cancer therapies
8. Scientific evidence of the significant anti-cancer effect of milk thistle
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... CA (PRWEB) , ... June 25, 2016 , ... As ... with Magna Cum Laude and his M.D from the David Geffen School of Medicine ... and returned to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set ... drug or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, ... traumatic event. , Trauma sufferers tend to feel a range of emotions, from depression, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile technology, ... , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can be ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty Network, affiliated ... Weintraub as a prominent plastic surgeon and the network’s newest partner. , ... most handsome men, look naturally attractive. Plastic surgery should be invisible.” He stands ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... Ontario , June 27, 2016  VMS Rehab ... Company,s Board will take whatever measures required to build ... Company,s stock which is currently listed on the OTC ... Wexler, Company Chairman and CEO, "We are seeing an ... difficult to understand, not only by the Company, but ...
(Date:6/24/2016)... CHAPEL HILL, N.C. , June 24, 2016 ... in healthcare decisions and regulators/payers have placed more ... this new environment, patient support programs in the ... support for patients, medications. Consequently, pharmaceutical companies are ... to ensure they are providing products and services ...
(Date:6/24/2016)... SAN FRANCISCO, Calif. , June 24, 2016 ... GBT ), a biopharmaceutical company developing novel therapeutics ... significant unmet needs, today announced the closing of ... shares of common stock, at the public offering ... shares in the offering were offered by GBT. ...
Breaking Medicine Technology: