Navigation Links
Carbon Monoxide May Help Bypass Surgery Patients
Date:5/23/2008

Low doses of gas found in car exhaust provides anti-inflammatory effects in lungs

FRIDAY, May 23 (HealthDay News) -- Low doses of carbon monoxide (CO) -- the potentially lethal gas in car exhaust fumes -- may help protect the lungs of patients undergoing cardiopulmonary bypass (CPB) surgery, German researchers say.

The team gave low doses of CO to pigs that underwent beating-heart CPB.

"Our findings support that inhaled CO provides anti-inflammatory effects in the lungs and decreases the instance of cell death during CPB," study author Dr. Torsten Loop, of the anesthesiology department at the University Medical Centre Freiburg, said in a prepared statement.

"Additionally, and of greater importance, these effects occurred when CO was administered as a pre-treatment -- with the advantage of short exposure time, which limits how avidly CO can bind to hemoglobin," Loop said.

This is important, because the poisonous effects of CO occur when it's allowed to freely bind to hemoglobin within red blood cells.

The study was published in the May issue of Anesthesiology.

"Cardiac surgery is one of the most extreme situations a patient can face," Loop noted. "Although a heart-lung machine ensures that organs are supplied with blood, and therefore oxygen, the nature of heart surgery means that normal operation of the lungs is impaired -- potentially resulting in lung injury."

Only about 2 percent of cardiac surgery patients suffer life-threatening lung injuries, but death rates for these patients can exceed 60 percent. This finding suggests CO could prove useful in reducing lung inflammation and cell death during CPB.

"A fascinating aspect of this study is that pre-treatment with CO before CPB was effective in protecting the lungs. These findings may support evidence that CO can trigger the body into a state that helps to protect it against the sometimes damaging effects of CPB," Dr. John G. Laffey, of the Clinical Sciences Institute at the National University of Ireland, wrote in an accompanying editorial.

The study results lend support to the feasibility of conducting human studies to examine the potential protective effects of CO on a number of organs.

"The demonstration that CO may reduce pulmonary inflammation and injury following CPB is an important and novel finding. Relative ease of administration, probable safety when given at low doses for short periods, and likely protective effects for multiple organs make this a fascinating agent with clear therapeutic promise," Laffey noted.

More information

The MedlinePlus Medical Encyclopedia has more about heart bypass surgery.



-- Robert Preidt



SOURCE: American Society of Anesthesiologists, news release, May 23, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Carbon nanotubes that look like asbestos, behave like asbestos
2. Carbon Nanotubes That Look Like Asbestos, Behave Like Asbestos
3. ESA contributes to ocean carbon cycle research
4. MarketResearch.com Announces Distribution of CarbonFree Research
5. Reducing carbon emissions could help -- not harm -- US economy
6. Tracking your carbon footprint
7. Wiley-Blackwell renews carbon neutral commitment
8. Routine screenings uncover hidden carbon monoxide poisoning
9. UT Southwestern plastic surgeons deploy new carbon dioxide-based fractional laser
10. Hot liquids release potentially harmful chemicals in polycarbonate plastic bottles
11. Activists Raise Alarm for Seniors, Deliver Carbon Monoxide Detectors to Atria Marland Place
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... Pixel Film ... Pro X. , "Film editors can give their videos a whole new perspective by ... Austin - CEO of Pixel Film Studios. , ProSlice Levels contains over 30 ...
(Date:6/26/2016)... ... , ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a ... fitness app plans to fix the two major problems leading the fitness industry today:, ... type program , They don’t eliminate all the reasons people quit their exercise ...
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due ... up a new, often overlooked aspect of head lice: the parasite’s ability to live away ... a common occurrence, but a necessary one in the event that lice have simply gotten ...
(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SAN FRANCISCO, Calif. , June 24, 2016 ... GBT ), a biopharmaceutical company developing novel therapeutics ... significant unmet needs, today announced the closing of ... shares of common stock, at the public offering ... shares in the offering were offered by GBT. ...
(Date:6/24/2016)... 2016 Dublin ... addition of the " Global Markets for Spectroscopy ... This report focuses on the ... review, including its applications in various applications. The report ... includes three main industries: pharmaceutical and biotechnology, food and ...
(Date:6/24/2016)... Va. , June 24, 2016 The ... set of recommendations that would allow biopharmaceutical ... (HCEI) with entities that make formulary and coverage decisions, ... the "value" of new medicines. The recommendations ... does not appear on the drug label, a prohibition ...
Breaking Medicine Technology: