Navigation Links
Carbon Monoxide May Help Bypass Surgery Patients
Date:5/23/2008

Low doses of gas found in car exhaust provides anti-inflammatory effects in lungs

FRIDAY, May 23 (HealthDay News) -- Low doses of carbon monoxide (CO) -- the potentially lethal gas in car exhaust fumes -- may help protect the lungs of patients undergoing cardiopulmonary bypass (CPB) surgery, German researchers say.

The team gave low doses of CO to pigs that underwent beating-heart CPB.

"Our findings support that inhaled CO provides anti-inflammatory effects in the lungs and decreases the instance of cell death during CPB," study author Dr. Torsten Loop, of the anesthesiology department at the University Medical Centre Freiburg, said in a prepared statement.

"Additionally, and of greater importance, these effects occurred when CO was administered as a pre-treatment -- with the advantage of short exposure time, which limits how avidly CO can bind to hemoglobin," Loop said.

This is important, because the poisonous effects of CO occur when it's allowed to freely bind to hemoglobin within red blood cells.

The study was published in the May issue of Anesthesiology.

"Cardiac surgery is one of the most extreme situations a patient can face," Loop noted. "Although a heart-lung machine ensures that organs are supplied with blood, and therefore oxygen, the nature of heart surgery means that normal operation of the lungs is impaired -- potentially resulting in lung injury."

Only about 2 percent of cardiac surgery patients suffer life-threatening lung injuries, but death rates for these patients can exceed 60 percent. This finding suggests CO could prove useful in reducing lung inflammation and cell death during CPB.

"A fascinating aspect of this study is that pre-treatment with CO before CPB was effective in protecting the lungs. These findings may support evidence that CO can trigger the body into a state that helps to protect it against the sometimes damaging effects of CPB," Dr. John G. Laffey, of the Clinical Sciences Institute at the National University of Ireland, wrote in an accompanying editorial.

The study results lend support to the feasibility of conducting human studies to examine the potential protective effects of CO on a number of organs.

"The demonstration that CO may reduce pulmonary inflammation and injury following CPB is an important and novel finding. Relative ease of administration, probable safety when given at low doses for short periods, and likely protective effects for multiple organs make this a fascinating agent with clear therapeutic promise," Laffey noted.

More information

The MedlinePlus Medical Encyclopedia has more about heart bypass surgery.



-- Robert Preidt



SOURCE: American Society of Anesthesiologists, news release, May 23, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Carbon nanotubes that look like asbestos, behave like asbestos
2. Carbon Nanotubes That Look Like Asbestos, Behave Like Asbestos
3. ESA contributes to ocean carbon cycle research
4. MarketResearch.com Announces Distribution of CarbonFree Research
5. Reducing carbon emissions could help -- not harm -- US economy
6. Tracking your carbon footprint
7. Wiley-Blackwell renews carbon neutral commitment
8. Routine screenings uncover hidden carbon monoxide poisoning
9. UT Southwestern plastic surgeons deploy new carbon dioxide-based fractional laser
10. Hot liquids release potentially harmful chemicals in polycarbonate plastic bottles
11. Activists Raise Alarm for Seniors, Deliver Carbon Monoxide Detectors to Atria Marland Place
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , ... mock evacuation of the facility as part of a disaster drill on October 3rd. ... EMS and Shelton City Emergency Manager, as well as the Connecticut Long Term ...
(Date:10/13/2017)... ... , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has ... least understood books in the Holy Scriptures, Revelation. The Book of Revelation paints a ... centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins says that ...
(Date:10/12/2017)... WILMINGTON, Del. (PRWEB) , ... October 12, 2017 ... ... technology and advisory services for healthcare compliance program management, will showcase a range ... and National Association for Assisted Living (NCAL) Convention and Expo to be held ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics (ACMI) ... FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s ... Morris F. Collen, a pioneer in the field of medical informatics, this prestigious award ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at ... for the 49th Congress of the International Society of Paediatric Oncology (SIOP) ... Center for Cancer and Blood Disorders at Children’s National, and Stephen P. ...
Breaking Medicine News(10 mins):
(Date:9/12/2017)... , Sept. 12, 2017   EcoVadis , the leading platform ... published the first annual edition of its Global CSR Risk and Performance ... evaluated by EcoVadis, based on Scorecard Ratings that analyzed nearly 800,000 data ... ... ...
(Date:9/12/2017)...  ValGenesis Inc., the global leader in Enterprise ... announce the appointment of Dr. Ajaz Hussain ... Directors and Chairman of Advisory Board beginning September ... to manage their entire validation lifecycle process electronically ... process. Furthermore, ValGenesis VLMS enables rigorous compliance, helps ...
(Date:9/9/2017)... 2017 Dealmed Medical Supplies, New ... equipment, supplies, drugs, vaccines, and specialty medical products and ... agreement to acquire Vantage Medical Supplies, a major distributor ... Holtsville, New York . ... emerging medical practices, will operate under the Dealmed name ...
Breaking Medicine Technology: