Navigation Links
Carbohydrate acts as tumor suppressor
Date:7/6/2009

LA JOLLA, Calif., July 6, 2009 Scientists at Burnham Institute for Medical Research (Burnham) have discovered that specialized complex sugar molecules (glycans) that anchor cells into place act as tumor suppressors in breast and prostate cancers. These glycans play a critical role in cell adhesion in normal cells, and their decrease or loss leads to increased cell migration by invasive cancer cells and metastasis. An increase in expression of the enzyme that produces these glycans, β3GnT1, resulted in a significant reduction in tumor activity. The research was published in the journal Proceedings of the National Academy of Sciences.

The specialized glycans are capable of binding to laminin and are attached to the α-DG cell surface protein. This binding facilitates adhesion between epithelial and basement membrane cells and prevents cells from migrating. The team of scientists, led by Professor Minoru Fukuda, Ph.D., demonstrated that β3GnT1 controls the synthesis of laminin-binding glycans in concert with the genes LARGE/LARGE2. Down-regulation of β3GnT1 reduces the number of glycans, leading to greater movement by invasive cancer cells. However, when the researchers forced aggressive cancer cells to express β3GnT1, the laminin-binding glycans were restored and tumor formation decreased.

"These results indicate that certain carbohydrates on normal cells and enzymes that synthesize those glycans, such as β3GnT1, function as tumor suppressors," said Dr. Fukuda." Upregulation of β3GnT1 may become a novel way to treat cancer."

Using antibodies, the team investigated the expression of both α-DG and its associated glycans in both normal and cancerous cells. They found that the quantity of α-DG was similar in both cell types, but the level of attached glycans was reduced in the cancer cells. Further study showed that prostate cancer cells that highly expressed the α-DG glycans produced smaller tumors. The team also found that when they knocked down β3GnT1 expression by RNA interference, which reduces protein expression, the amount of glycans decreased even when LARGE was overexpressed.

The scientists demonstrated that β3GnT1 plays a key role in forming laminin-binding glycans attached to α-DG, which in turn reduces cancer cell movement. The study provides a new understanding of the role that complex carbohydrates play in cancer and could lead to new directions in the development of therapeutics.


'/>"/>

Contact: Josh Baxt
jbaxt@burnham.org
858-795-5236
Burnham Institute
Source:Eurekalert

Related medicine news :

1. Limiting refined carbohydrates may stall AMD progression
2. Carbohydrate restriction may slow prostate tumor growth
3. Chocolate Milks Natural Muscle Recovery Benefits Match or May Even Surpass a Specially Designed Carbohydrate Sports Drink
4. Tumors use enzyme to recruit regulatory T-cells and suppress immune response
5. Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
6. Study details regulation of vital tumor suppressor gene p53
7. Human C-reactive protein regulates myeloma tumor cell growth and survival
8. Customized virus kills brain tumor stem cells that drive lethal cancer
9. Study suggests brain tumors need treatment with multiple targeted drugs
10. Bright tumors, dim prospects
11. National Brain Tumor Foundation Unites with BrainLAB in Support of Patient Education
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/19/2017)... ... ... Today, the Centers for Medicare & Medicaid Services (CMS) announced over 359,000 clinicians ... Clinicians who participate in APMs are paid for the quality of care they give ... build a system that delivers better care and one in which clinicians work together ...
(Date:1/19/2017)... ... January 19, 2017 , ... Wells Pharmacy Network announced the ... 503A compounding pharmacy located in Ocala, Florida. , Meeting the Needs of ... the United States for high-quality human anti-aging and wellness compounded medications, ...
(Date:1/19/2017)... ... January 19, 2017 , ... LabRoots , ... from around the world, announces the launch of its newly redesigned website. The ... to research breakthroughs and trending news, vital information on upcoming virtual events and ...
(Date:1/19/2017)... ... January 19, 2017 , ... Cosmetic Town, an online ... procedures in order to make it easier for their readers to get the information ... they impact as well as the techniques used on those particular areas. , “We ...
(Date:1/19/2017)... NJ (PRWEB) , ... January 19, 2017 , ... ... certified dermatologist by the American Board of Dermatology and fellowship trained Mohs and ... the National Institutes of Health, Dr. Li completed his internship in internal medicine ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... -- Shire plc (LSE: SHP, NASDAQ: ... Drug Administration (FDA) has acknowledged receipt of the Class ... SHP465, a long-acting, triple-bead, mixed amphetamine salts formulation. SHP465 ... Attention-Deficit/Hyperactivity Disorder (ADHD). The FDA is expected to provide ... designated Prescription Drug User Fee Act (PDUFA) action date. ...
(Date:1/19/2017)... 19, 2017 The global  pacemaker market  is expected to ... View Research, Inc. The heightening prevalence of cardiac conditions coupled with the availability ... globally. In addition, technological enhancements in these devices are supporting the expansion of ... ... Grand View Research Logo ...
(Date:1/19/2017)... Md. , Jan. 18, 2017   ... late-stage clinical company developing therapeutics designed to preserve ... of patients, today confirmed plans to initiate a ... Company,s modified-release reformulation of lovastatin lactone designed to ... smithii) in the gut to treat the ...
Breaking Medicine Technology: