Navigation Links
Capturing live tumor cells in the blood
Date:8/8/2013

WASHINGTON D.C., August 8, 2013 -- Tumor cells circulating within a patient's bloodstream can carry cancer from a primary tumor site to distant sites of the body, spreading the disease.

Now a team of researchers in China has developed a new microfluidic chip that can quickly and efficiently segregate and capture live circulating tumor cells (CTCs) from a patient's blood, with potential applications for cancer screenings and treatment assessments. The researchers describe their technique in the journal Biomicrofluidics, which is produced by AIP Publishing.

Many currently available devices for detecting CTCs in patients' blood are either too slow for clinical use or have other problems, such as a reduced ability to distinguish between the rare CTCs and more common white blood cells and other non-tumor cells.

The new system captures more than 90 percent of the CTCs, which makes it highly efficient. Overall processing time has also been shortened, thanks in part to a step in which red blood cells are selectively lysed, or broken apart. Lysing the red blood cells diminishes the tendency of blood to clog the system, a common problem that slows processing time in similar CTC filtering devices.

The ability to count live, individual CTCs in the bloodstream can help doctors determine the severity of a cancer, since CTC density in the blood is linked to the progression of the disease and patients' likelihood of survival. The new method could also improve "liquid biopsy" techniques, in which a small amount of blood is drawn as an alternative to conventional tissue biopsies of primary or metastatic tumors.

In addition to potentially improving screening tests, the team believes their approach may someday help doctors control CTC-induced metastasis, which the researchers say can be far more lethal than the original tumor.

"Because our chip is able to capture viable CTCs, it creates opportunities for the development of new and efficient cancer biomarkers," says co-author Ray Han, a professor at Peking University in Beijing. It also gives researchers a chance to realize what Han calls "the grandest dream of all: a technology capable of directly removing CTCs from the human bloodstream a form of CTC dialysis."


'/>"/>

Contact: Jason Socrates Bardi
jbardi@aip.org
240-535-4954
American Institute of Physics
Source:Eurekalert

Related medicine news :

1. Capturing circulating cancer cells could provide insights into how disease spreads
2. Improved Stem Cell Line May Avoid Tumor Risk: Study
3. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
4. Dental X-Rays May Be Linked to Benign Brain Tumors
5. Live imaging shows response to cancer drugs can be boosted by altering tumor microenvironment
6. Brain Tumor Vaccine Shows Promise in Early Trial
7. Kidney Cancer Patients Fare Better With Tumor Removal Only
8. IBN discovers human neural stem cells with tumor targeting ability
9. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
10. Small molecular bodyguards kill HPV-infected cancer cells by protecting tumor-suppressor
11. New surgical technique for removing inoperable tumors of the abdomen
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... ... May 26, 2017 , ... ... new educational seminar to focus on current legislative activity and the latest regulatory ... at 1 p.m. Sunday, Sept. 10, and will continue through Monday, Sept. 11, ...
(Date:5/26/2017)... (PRWEB) , ... May 26, 2017 , ... ... premium delicatessen foods, is sharing bold recipes for Memorial Day entertaining that are ... menus. , “Boar’s Head fresh sliced meats and cheeses featured in these ...
(Date:5/26/2017)... ... May 26, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at ... that is focusing on the Peace Agreements being discussed by President Donald Trump and ... a race to try to speed up peace talks in the continuous battle between ...
(Date:5/26/2017)... (PRWEB) , ... May 26, 2017 , ... “When the ... Lead Home” is the creation of published author Laura Weigel Douglas, an avid reader ... cat in a house that sometimes feels like Green Hills Adventure Camp. She couldn’t ...
(Date:5/26/2017)... ... May 26, 2017 , ... “Cactus Jack: Against All ... so many others. “Cactus Jack: Against All Odds” is the creation of published ... D. Hubbard is married to Jack Carlisle’s third child Jane. Walter. Walter and ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)... Zimmer Biomet Holdings, Inc. (NYSE and SIX: ... it has earned a spot on Forbes, ... was ranked among 500 U.S. employers as well as ... and Services. The annual Forbes ... survey of over 30,000 employees across 25 industries. The ...
(Date:5/9/2017)... 9, 2017  Semler Scientific, Inc. (OTCQB: SMLR), ... to improve the clinical effectiveness and efficiency of ... first quarter ended March 31, 2017. ... customers to identify when preventive care options are ... like heart attacks or strokes occur," said ...
(Date:5/6/2017)... Provista , a proven leader in the supply chain industry ... Jim Cunniff as the company,s new president and CEO. ... Provista, including most recently serving as the president and CEO ... He assumed his new role with Provista on May 1, ... says Jody Hatcher , president, Sourcing and Collaboration Services ...
Breaking Medicine Technology: