Navigation Links
Cannabis Compound May Stop Metastatic Breast Cancer
Date:11/19/2007

But patients can't get enough CBD from just smoking pot, scientists add

MONDAY, Nov. 19 (HealthDay News) -- A non-toxic, non-psychoactive compound in marijuana may block the progress of metastatic breast cancer, according to a new study by researchers in California.

"This is a new way to treat a patient that is not toxic like chemotherapy or radiotherapy. It is a new approach for metastatic cancer," said lead researcher Sean D. McAllister, an associate scientist at the California Pacific Medical Center Research Institute in San Francisco.

The compound found in cannabis, called cannabidiol (CBD), inhibits a gene, Id-1, that researchers believe is responsible for the metastatic process that spreads cells from the original tumor throughout the body.

Opting for a musical metaphor, senior researcher Pierre-Yves Desprez likened Id-1 to "an [orchestra] conductor. In this case, you shoot the conductor, and the whole orchestra is going to stop. If you shoot the violinist, the orchestra just continues to play."

In humans, the Id-1 gene is found only in metastatic cancer cells, said Desprez, a staff scientist at the institute. Before birth, they are present and involved in the development of human embryos, but after birth, they go silent -- and should stay that way, he said.

But in metastatic cancer "when [the genes] wake up, they are very bad," he said. "They push the cells to behave like embryonic cells and grow. They go crazy, they proliferate, they migrate." Desprez said, "We need to be able to turn them off."

According to the study, CBD does exactly that.

"We are focusing on the latest stages of cancer," Desprez added. The cancer cell itself is not the problem, because a tumor can be "removed easily by surgery," he said. The problem is the development of metastatic cells which is "conducted" by Id-1.

McAllister and Desprez said they are not suggesting that patients with hormone-independent metastatic breast cancer smoke marijuana. For one thing, a sufficient amount of CBD could never be obtained in that way, they said.

The research that has been done on marijuana and its compounds, however, is helpful, McAllister, said. CBD has been around for a long time, and researchers have found it is not psychoactive, and its "toxicity is very low," he added.

The new findings are published in the November issue of Molecular Cancer Therapeutics.

If McAllister's and Desprez's work results in the development of a cancer treatment, someone with metastatic cancer might be placed on CBD for several years. That means low toxicity is important, McAllister explained.

McAllister also suggested that Id-1 is "so important in providing the [metastatic] mechanism in these cells in so many types of cancers" that they "provide us an opportunity potentially to target other types of cancers."

The study's findings were "were a serendipitous discovery, in a way," McAllister said. Desprez noted that he had been working on the Id-1 gene for 12 years. His lab had demonstrated that it was a key gene for invasive breast cancer and tumor progression, and Desprez had found a way to inhibit it in mice, but not in humans.

Then, two years ago, McAllister -- an expert on cannabinoids -- and Desprez, a cancer researcher, started to work together. Through their combined forces "what we found is actually what I was looking for for the last 12 years," Desprez said.

Further study is needed before CBD can be conclusively identified as a treatment option, McAllister and Desprez said. "We need to involve a team of physicians, because we are bench [basic] scientists," McAllister said.

One expert called the findings intriguing but preliminary.

"This is the first evidence that a cannabinoid can target the expression of an important breast cancer metastasis gene," noted Manuel Guzman, a Spanish expert on cannabinoids and cancer. He described the California study as giving "preliminary insight into the question of whether CBD could be used clinically to treat metastatic breast cancer."

However, "all the experiments in the paper have been conducted in cultured cells and none of them in any animal model of breast cancer, which would be one of the steps for further research," added Guzman, who is a professor of biochemistry and molecular biology at Complutense University in Madrid.

Guzman also noted that "Id-1 is just one of many genes involved in breast cancer metastasis" and that future research also needs to examine the impact of CBD on these other metastasis genes.

More information

There's more on breast cancer at the U.S. National Cancer Institute.



SOURCES: Sean D. McAllister, Ph.D., associate scientist, California Pacific Medical Center Research Institute, San Francisco; Pierre-Yves Desprez, Ph.D., staff scientist, California Pacific Medical Center Research Institute, San Francisco; Manuel Guzman, Ph.D., professor, biochemistry and molecular biology, Complutense University, Madrid, Spain; November 2007, Molecular Cancer Therapeutics


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Role seen for cannabis in helping to alleviate allergic skin disease
2. Smoked cannabis proven effective in treating neuropathic pain
3. Emotional Intelligence and the use of tobacco and cannabis
4. Coloring Compound in Fruits, Veggies May Cut Colon Cancer Risk
5. Sugary Sodas High in Diabetes-Linked Compound
6. Red wine compound shown to prevent prostate cancer
7. CutisPharma Selected by Medicine Shoppe International as Preferred Vendor for Unit-of-Use Compounding Kits
8. A Chinese medicine compound has satisfactory anti-cancer effects on hepatocellular carcinoma
9. VioQuest to Present Data on Oncology Compounds VQD-002 and Lenocta(TM) at AACR-NCI-EORTC International Meeting
10. Organon Signs an Exclusive, Worldwide Licence Agreement on Advanced Antithrombotic Compounds With Endotis Pharma
11. Primus Innovations and Health Robotics Launch Strategic Partnership to Accelerate Transformation in Chemotherapy Compounding
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cannabis Compound May Stop Metastatic Breast Cancer
(Date:4/24/2017)... , ... April 24, 2017 , ... ... within the telehealth industry, announces the company’s VideoMedicine mobile platform has launched Quick ... Available 24 hours a day, Quick Care provides patients with the option to ...
(Date:4/24/2017)... ... 2017 , ... Rod Burkett, CEO of Gardant Management Solutions, was recently featured ... at the forefront of Gardant since it was founded in 1999. His drive and ... of more than 40 new senior living communities. With his leadership, Gardant has grown ...
(Date:4/24/2017)... ... April 24, 2017 , ... Donna Parker, L. Ac. reads ... not found any of them to be very practical. She wanted to write a ... make changes in their health. It prompted her in writing “ A Clear Path ...
(Date:4/24/2017)... ... 2017 , ... Miami Periodontist and Dental Implant ... Foundation’s 2017 Symposium on Tissue Regeneration and Implant Dentistry held in Miami Beach ... Symposium at the Fontainebleau Hotel located in Miami Beach, FL. This annual symposium ...
(Date:4/23/2017)... ... April 23, 2017 , ... "An event Horizon is a place where the ... my Art and Music. These are created as Metaphysical Transformations where music, which is ... culminate to the ultimate singularity.", -- Karen Salicath Jamali , Karen will also preview ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... , April 20, 2017  Vivify Health, the pioneer ... has been awarded a very significant patent for the ... to continual care via digital health.  This landmark patent ... property and further secures Vivify,s position as the leader ... 2009, was the first company to apply consumer mobile ...
(Date:4/20/2017)... April 20, 2017 Research and Markets has ... Innovation Driven by Rapidly Expanding Injectables Market and Increasing Usage of ... ... delivery technologies will rise from USD 20 Billion in 2015 to ... Drug Delivery Technologies - Innovation Driven by Rapidly Expanding Injectables Market ...
(Date:4/20/2017)... Research and Markets has announced the ... Application Analysis, Regional Outlook, Growth Trends, Key Players, Competitive Strategies ... ... was valued at US$ 7,167.6 Mn in 2015, and is ... a CAGR of 5.6% from 2016 to 2024. ...
Breaking Medicine Technology: