Navigation Links
Cancers with disorganized 'traffic systems' more difficult to treat: U of A research
Date:6/21/2012

Medical researchers at the University of Alberta reviewed test results from thousands of patients with various types of cancer and discovered that "disorganized" cancers were more difficult to treat and consistently resulted in lower survival rates.

Principal investigator Jack Tuszynski says physicians could use a mathematical equation, or algorithm, to determine how disorganized their patients' cancer is. Once physicians determine that, then they could pinpoint which cancer treatment would be the most effective. Some cancer drugs are effective at treating simple cancers, while others are designed to attack complex cancers.

The current emphasis in cancer treatment is to inhibit "traffic systems" in cancer, says the researcher.

"Using a math equation, doctors could predict if a given therapy will be successful, which would spare the patient from suffering," says Tuszynski, who holds the Alberta Cancer Foundation-funded Allard Research Chair in Oncology with the Faculty of Medicine & Dentistry at the University of Alberta. "Instead of spending millions of dollars on clinical trials to find better cancer drugs, algorithms could be used to better pinpoint treatment instead."

The research conducted by Tuszynski, a summer student, and research colleagues in Boston, was recently published in the peer-reviewed journal Proceedings of the National Academy of Sciences (PNAS). The group looked at 14 types of cancer, including those with high survivability, like prostate cancer, and those with high death rates, such as pancreatic cancer. Each type of cancer has its own unique "metro map," says Tuszynski.

"These traffic signalling systems inside cancer cells look like transportation hubs or metro maps, so you can measure how many stations and how many lines you have," says Tuszynski, who has a joint appointment in the Department of Oncology, as well as the Department of Physics in the Faculty of Science.

"The surprising part is, the more disorganized the traffic signalling system, the more robust and stubborn the cancer is against chemotherapy. If cancer cells have a complex metro map with lots of branches at various locations, then the cancer is very hard to paralyze.

"This research discovery has given us a glimpse into an important issue in cancer treatment. The finding is very telling."

The Alberta Cancer Foundation, which funded the research, is excited about the discovery.

"Dr. Tuszynski's work in computational biophysics promises to create more personalized treatment for cancer patients by targeting the cancerous cells while reducing side effects to healthy cells," says Myka Osinchuk, CEO of the Alberta Cancer Foundation. "This latest research discovery will help push the pace of discovery and we are excited to hear more about the progress being made in this area."

Tuszynski is continuing his research in this area and expects to soon publish more related findings.


'/>"/>

Contact: Raquel Maurier
raquel.maurier@ualberta.ca
780-492-5986
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Related medicine news :

1. HPV-Related Head, Neck Cancers on the Rise
2. LSUHSC research finds HPV-related head & neck cancers rising, highest in middle-aged white men
3. Kinase test may yield big gains for drug-resistant cancers
4. Vitamin E in diet protects against many cancers
5. Infection Causes 1 in 6 Cancers Worldwide: Study
6. Fertilizing bone marrow helps answer why some cancers spread to bones
7. Experimental Drug Helps Fight Some Childhood Cancers, Study Finds
8. Protein RAL associated with aggressive characteristics in prostate, bladder and skin cancers
9. Discovery suggests new combination therapy strategy for basal-like breast cancers
10. Moffitt researcher, colleagues find success with new immune approach to fighting some cancers
11. Gum Disease, HPV May Play Role in Head & Neck Cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements owned by ... to enhance the health of felines. The formula is all-natural and is made from ... the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract ...
(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
(Date:6/25/2016)... TX (PRWEB) , ... June 25, 2016 , ... Austin ... of the American College of Mohs Surgery and to Dr. Russell Peckham for medical ... and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery ...
(Date:6/25/2016)... Aliso Viejo, California (PRWEB) , ... June 25, 2016 , ... ... preset to fit their specific project," said Christina Austin - CEO of Pixel Film ... all fully customizable and all within Final Cut Pro X . Simply select ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, ... and his M.D from the David Geffen School of Medicine at UCLA. He trained ... Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 Research and Markets has ... - Forecast to 2022" report to their offering. ... for the patients with kidney failure, it replaces the function ... the patient,s blood and thus the treatment helps to keep ... in balance. Increasing number of ESRD patients ...
(Date:6/23/2016)... , June 23, 2016 Research and ... Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data derived ... Assessment of major trends with potential impact on the market ... of market segmentation which comprises of sub markets, regional and ...
(Date:6/23/2016)... and INDIANAPOLIS , June ... receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship is any ... scholarship winners, announced today online at www.diabetesscholars.org ... type 1 diabetes stand in the way of academic ... supported the Foundation,s scholarship program since 2012, and continues ...
Breaking Medicine Technology: