Navigation Links
Cancer's break-in tools possibly identified at Duke
Date:8/17/2009

have enabled Sherwood to do a variety of experiments to narrow down the genes and molecular signals in play. And, with newly developed imaging technologies, they can actually watch as the cell invasion occurs.

"In vivo, you're dealing with individual cancer cells moving around the body. It is very hard to watch that,." Sherwood said. "And then asking the cancer cell 'what genes are you using to do that?' is even more difficult."

From the latest set of findings with the model organism, Sherwood believes that integrin helps the anchor cell orient itself toward the basement membranes, and that it also directs netrin to build the puncta in the proper place to ease an opening through. Interestingly, netrin is also the signal that encourages developing neuron cells to branch out and make new connections.

What's even more encouraging about both of these molecules is that they're outside the cell, Sherwood said, making them easier to target with possible drug therapy.

There are about 100 genes that seem to prevent cell invasion, and Sherwood's team is searching for those that might be the most effective. A gene called SPARC, for example, is known to be over-active in cancer cells, enabling easier penetration of the basement membrane. They are currently examining how this gene helps the anchor cell invade.

He said they would like to know how the cell turns on "invasiveness" to understand the best way to interrupt this potentially lethal behavior.

Sherwood's research was supported by a Basil O'Connor Award, Pew Scholars Award and a grant from the National Institutes of Health.


'/>"/>

Contact: Karl Leif Bates
karl.bates@duke.edu
919-681-8054
Duke University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Infection contributes to the high rates of oropharyngeal cancers
2. Smoking increases risks for head and neck cancers for men and women
3. Smoking Boosts Risk for Head, Neck Cancers
4. Oral Sex Implicated in Some Throat and Neck Cancers
5. Generic prostate drug helps find high-risk cancers early
6. Finasteride unlikely to induce high grade prostate cancers
7. More Prostate Cancers Might Be Prevented
8. Ultrasound plus mammography finds more cancers, but increases false positives
9. MU researchers studying model to learn why certain cancers become resistant to drugs
10. New All-Natural Dietary Supplement Made from Muscadine Grape Skins Helps Inhibit Growth of Certain Cancers
11. Three Chemo Drugs Better Than Two for Advanced Head/Neck Cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... York (PRWEB) August 28, 2014 An unprecedented ... and neck issues, Cloud 9 Spine offers their resources online ... problems can quickly become a brick wall of discouragement as ... a professional opinion, Cloud 9 Spine offers a ... technology merged with human interaction that sets Cloud 9 Spine ...
(Date:8/28/2014)... 28, 2014 Top 10 Best ... hosting companies and announces Bluehost, HostMonster ( http://www.hostmonster.com/track/seohosts ... for the webmasters worldwide who want to buy ... As the world’s most popular server-side scripting language, ... other general-purpose programs. It is now installed on ...
(Date:8/28/2014)... Now in its 4th year, Step ... 2011 by two brain aneurysm survivors. The ongoing mission of ... education to help increase early detection and to help support ... aneurysm. We hope that you will be able to join ... 4th Annual Step for Hope Run/ Walk on Saturday, September ...
(Date:8/28/2014)... CA (PRWEB) August 28, 2014 MarijuanaDoctors.com ... California physician, James Patel M.D. of Livermore, California. As ... best and most qualified physicians, and in accordance with ... our patients to Dr. Patel’s practice. , Initially finding ... a young age, Dr. Patel was shaped by his ...
(Date:8/28/2014)... 28, 2014 The Pulmonica is a ... resonant, meditative sounds that can be felt vibrating in ... to use it – just taking long, slow, deep ... , Here are some examples of how to ... your eyes, relax, and maintain good posture. Try to ...
Breaking Medicine News(10 mins):Health News:Making Waves on the East Coast, Cloud 9 Spine is Helping Patients Find Appointments With Local Spine Doctors 2Health News:Step for Hope and Raise Brain Aneurysm Awareness 2Health News:Army Colonel Dr. James Patel Joins the Medical Marijuana Industry 2Health News:Army Colonel Dr. James Patel Joins the Medical Marijuana Industry 3Health News:Army Colonel Dr. James Patel Joins the Medical Marijuana Industry 4Health News:Ever Thought of Meditating With a Harmonica; Harmonica Techs, Inventors of the Pulmonica® Pulmonary Harmonica®, Present Tips on How to Relax with Soothing Sounds 2
... favor of drugs in the pipeline, review finds , ... of drug studies published in major medical journals answer ... available medications works best for a particular condition. , ... effectiveness" studies, where experts seek to determine which available ...
... more than 80,000 who gave one up shows procedure carries ... a kidney carries few health risks, with donors living just ... donate, the largest study to date of donors has found. ... who donated a kidney between 1994 and 2009, researchers found ...
... ... ... ... ...
... , ... ... ... ...
... ... ... ... ...
... a certain type of genetic susceptibility to lung cancer ... with even a small exposure to cigarette smoke, a ... Cincinnati (UC) has concluded. For family members who carry ... similar for both light and heavy smokers, the researchers ...
Cached Medicine News:Health News:Most Drug Studies Don't Help Docs Pick Best Treatment 2Health News:Most Drug Studies Don't Help Docs Pick Best Treatment 3Health News:Kidney Donors Go On to Lead Long, Healthy Lives 2Health News:Kidney Donors Go On to Lead Long, Healthy Lives 3Health News:Introducing KePRO(TM) Engage Health - A Revolutionary Wellness & Lifestyle Management Company 2Health News:Introducing KePRO(TM) Engage Health - A Revolutionary Wellness & Lifestyle Management Company 3Health News:Introducing KePRO(TM) Engage Health - A Revolutionary Wellness & Lifestyle Management Company 4Health News:Introducing KePRO(TM) Engage Health - A Revolutionary Wellness & Lifestyle Management Company 5Health News:Online Tool Created to Contact Vatican Officials: 'Why Are American Bishops Allowed to Defy the Pope's Words Concerning Child Killing and the Eucharist?' 2Health News:Online Tool Created to Contact Vatican Officials: 'Why Are American Bishops Allowed to Defy the Pope's Words Concerning Child Killing and the Eucharist?' 3Health News:Online Tool Created to Contact Vatican Officials: 'Why Are American Bishops Allowed to Defy the Pope's Words Concerning Child Killing and the Eucharist?' 4Health News:Online Tool Created to Contact Vatican Officials: 'Why Are American Bishops Allowed to Defy the Pope's Words Concerning Child Killing and the Eucharist?' 5Health News:GoodTherapy.org and PsychCentral.com Partner to Help Therapy Seekers Find a Therapist 2Health News:GoodTherapy.org and PsychCentral.com Partner to Help Therapy Seekers Find a Therapist 3Health News:GoodTherapy.org and PsychCentral.com Partner to Help Therapy Seekers Find a Therapist 4Health News:GoodTherapy.org and PsychCentral.com Partner to Help Therapy Seekers Find a Therapist 5Health News:GoodTherapy.org and PsychCentral.com Partner to Help Therapy Seekers Find a Therapist 6Health News:Genetic variant greatly increases lung cancer risk for light smokers 2
(Date:8/27/2014)... An experimental drug designed to help regulate the blood,s iron ... of inflammation, according to results from the first human ... Blood , the Journal of the American ... a condition that occurs when red blood cells are in ... has anemia, the body does not get enough oxygen, since ...
(Date:8/27/2014)... -- Kewaunee Scientific Corporation (Nasdaq: KEQU ) ... cash dividend by 9% to twelve cents per outstanding ... the dividend payable on September 22, 2014 to stockholders ... 8, 2014. About Kewaunee Scientific ... is a recognized global leader in the design, manufacture, ...
(Date:8/27/2014)... NINGBO, China , Aug. 27, 2014 /PRNewswire/ ... Co., Ltd, ("Menovo") today announced they had entered into ... primarily targeting the United States ... Menovo will jointly develop products for Amerigen to commercialize ... will be responsible for manufacturing API and finished product ...
Breaking Medicine Technology:Drug Represents First Potential Treatment for Common Anemia 2Drug Represents First Potential Treatment for Common Anemia 3Amerigen Pharmaceuticals Limited and the Ningbo Menovo Pharmaceutical Co., Ltd, today announced they had entered into a collaboration agreement regarding the development of generic pharmaceuticals, primarily targeting the United States market 2
... The Halifax Health - Betty Jane France Center ... of a new decade of caring by unveiling a ... held this afternoon in Daytona Beach, Fla. ... will celebrate the 10th anniversary of Speediatrics. In recognition ...
... flu hospitalization rates for African-Americans, Hispanics, and American Indian/Alaska ... for Whites during the 2009-2010 flu season, according to ... the Trust for America,s Health (TFAH). At the same ... lower for African Americans and Hispanics than for Whites. ...
Cached Medicine Technology:Speediatrics Unit Celebrates 10th Anniversary 2Speediatrics Unit Celebrates 10th Anniversary 3New Report Finds H1N1 Hospitalization Rates Higher But Vaccination Rates Lower for Minorities 2New Report Finds H1N1 Hospitalization Rates Higher But Vaccination Rates Lower for Minorities 3New Report Finds H1N1 Hospitalization Rates Higher But Vaccination Rates Lower for Minorities 4
... The SourceLink™ Delivery System offers a ... It addresses the challenges associated with ... provides the flexibility of seed and ... packaged per customers desired quantity and ...
... The Bard EXPRESS Seeding Cartridge System is ... delivering radioactive seeds and spacers into a ... Each cartridge has a(n): outer radiation safety ... synthetic absorbable spacers, integrally molded fitting that ...
... The Sysmex UF-100 is designed to ... microscopic analysis. It combines the superior ... automated urine sample analysis. Continuous sampling ... the rack-based autosamplers, streamlining sample processing in ...
... Q-Track II Holter Monitoring System uses technology ... the worlds first true 12-lead digital Holter ... of any beat contained in the 24-hour ... ,The preprocessing work done by the Q-12 ...
Medicine Products: