Navigation Links
Cancer vaccine could use immune system to fight tumors
Date:2/27/2014

CINCINNATICincinnati Cancer Center (CCC) and UC Cancer Institute researchers have found that a vaccine, targeting tumors that produce a certain protein and receptor responsible for communication between cells and the body's immune system, could initiate the immune response to fight cancer.

These findings, published in the Feb. 27 online edition of the journal Gene Therapy, build on previously reported research and could lead to new treatments for cancer.

Principal Investigator John Morris, MD, clinical co-leader of the Molecular Therapeutics and Diagnosis Program for the CCC, co-leader of the UC Cancer Institute's Comprehensive Lung Cancer Program, professor in the division of hematology oncology at the UC College of Medicine and UC Health medical oncologist, says a number of antitumor vaccines have shown promise for causing immune responses against tumor antigens to improve patient outcomes.

"Recently, human Interleukin-15 (IL-15) has entered clinical trials for treatment of patients with melanoma, a type of skin cancer, and renal cancer. In this study, we examined the effectiveness of a vaccination targeting tumors that produced IL-15 and its cell surface receptor called IL-15R-alpha () and examined their ability to up-regulate (or increase) immune responses to tumor antigens," Morris says. "We showed that the presence of both IL-15 with its receptor IL-15Rα increased the cell-surface production and secretion of IL-15, and in turn, stopped tumor cells from reproducing."

Researchers used IL-15 to develop a whole tumor cell vaccine to target breast (TS/A) and prostate (TRAMP-C2) cancer cells in animal models; results showed that tumor cells stopped growing after the vaccine was introduced and that beneficial effects were enhanced further when IL-15Rα was co-produced by the vaccine cells.

Morris says vaccination with modified tumor cells producing IL-15 and IL-15Rα slowed tumor growt
'/>"/>

Contact: Katie Pence
katie.pence@uc.edu
513-558-4561
University of Cincinnati Academic Health Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. More intensive radiotherapy is better than less for localized prostate cancer
2. Skin cancer risk may have driven evolution of black skin
3. Penn researchers show nuclear stiffness keeps stem cells and cancer cells in place
4. CWRU researchers find byproducts of bacteria-causing gum disease incite oral cancer growth
5. Building a better mouse model to understand pancreatic cancer
6. The only top 10 cancer where survival rates are falling
7. A paper diagnostic for cancer
8. Uninsured adolescents and young adults more likely to be diagnosed with advanced cancer
9. Dismantling pancreas cancers armor
10. Feasible, safe to limit radiation to major salivary glands in head and neck cancer patients
11. Patients with oropharyngeal cancer report quality of voice and speech affected post-treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... Winston-Salem, NC (PRWEB) September 20, 2014 The excitement ... held in Mount Airy, North Carolina. This year the Surry ... that draws people from around the country who are still fans ... Griffith Show is a sitcom that aired on CBS from 1960 ... 9th best show in American television history. Mount Airy, North ...
(Date:9/20/2014)... 2014 Plumbing construction services ... 5, indicating a moderately favorable purchasing environment for buyers. ... current and future pricing trends that will limit the ... factors that negatively affect buyer power are a lack ... the moderate switching costs. Buyers benefit, however, from low ...
(Date:9/20/2014)... 20, 2014 Final Cut Pro X ... release of the Information theme for FCPX filmmakers. , “Fun, ... describe the Information theme,” says Christina Austin, CEO of Pixel ... so professional.” , Information features easy to use controls that ... the environment. Change the background color, color of each circle ...
(Date:9/20/2014)... Nevada (PRWEB) September 20, 2014 ... extremely successful showing at the PAIN Week conference ... Cosmopolitan Hotel and Casino in Las Vegas from ... MarijuanaDoctors.com primarily attended PAIN Week in the hopes ... as a viable and legitimate tool to treat ...
(Date:9/19/2014)... (PRWEB) September 19, 2014 “Copay coupons,” ... sales of brand drugs among patients with prescription drug ... according to a new report from the Department ... General (OIG). Federal anti-kickback laws prohibit suppliers from offering ... by the federal government. , The report highlights that ...
Breaking Medicine News(10 mins):Health News:Mayberry Days Parade Cars will be Provided by Mount Airy Toyota and Mount Airy Chrysler Dodge Jeep Ram 2Health News:Plumbing Construction Services Procurement Category Market Research Report from IBISWorld Has Been Updated 2Health News:Plumbing Construction Services Procurement Category Market Research Report from IBISWorld Has Been Updated 3Health News:Plumbing Construction Services Procurement Category Market Research Report from IBISWorld Has Been Updated 4Health News:Today Pixel Film Studios Announced the Release of the Information Theme for Final Cut Pro X 2Health News:MarijuanaDoctors.com Experiences Unprecedented Support and Growth at Pain Week 2014 2Health News:PCMA: New OIG Report Cites Drug Manufacturer“Copay Coupon” Use in Medicare Part D 2
... Unit in Leeds receives Lilly,s 2008 Global ... ... Inc. (NYSE:,CVD), a leading provider of drug development services, today announced ... Lilly and Company., Covance,s clinical research unit based in Leeds, ...
... According to recent,reporting, including today,s Washington ... is circulating a draft proposed,regulation that, if ... providers to withhold the critical health care ... about their care. As a leading health,care ...
... Data for Second ... Quarter 2008 ... July 31 Sunrise Senior Living,Inc. (NYSE: SRZ ) today announced that ... the Securities and Exchange Commission,("SEC"). The Company also reported preliminary selected financial and,operating ...
... in chronic kidney cases , , THURSDAY, July 31 (HealthDay ... routinely measured marker of bone disease -- may signal ... for chronic kidney disease, say U.S. researchers. , The ... a three-year period. It found that patients with alkaline ...
... Therapeutics,Inc. (Nasdaq: HALO ), a biopharmaceutical company ... that it will release financial results for the ... market open on Friday, August 8, 2008., ... Gregory Frost,PhD, Vice President and Chief Scientific Officer, ...
... WEST CHESTER, Ohio, July 31 AtriCure, Inc.,(Nasdaq: ATRC ), ... today announced that it will present at the following,investor conferences during ... August 6, 2008 at the Millennium Broadway ... and Chief Executive Officer, is scheduled to present at 9:00 ...
Cached Medicine News:Health News:Covance Recognized for Outstanding Customer Service by Eli Lilly and Company 2Health News:SPOKESPERSON AVAILABILTY: Planned Parenthood President Available for Interviews on Proposed HHS Regulations 2Health News:Sunrise Files 2007 Form 10-K 2Health News:Sunrise Files 2007 Form 10-K 3Health News:Sunrise Files 2007 Form 10-K 4Health News:Sunrise Files 2007 Form 10-K 5Health News:Sunrise Files 2007 Form 10-K 6Health News:Sunrise Files 2007 Form 10-K 7Health News:Sunrise Files 2007 Form 10-K 8Health News:Sunrise Files 2007 Form 10-K 9Health News:Sunrise Files 2007 Form 10-K 10Health News:Sunrise Files 2007 Form 10-K 11Health News:Bone Disease Test Shows Death Risk for Dialysis Patients 2Health News:Halozyme Therapeutics to Hold Pipeline Update Conference Call on August 8 2Health News:AtriCure to Present at the BMO Focus on Healthcare and Canaccord Adams Global Growth Conferences in August 2
(Date:9/19/2014)... 19, 2014 /PRNewswire-iReach/ -- Market Research Report ... 2009-2019 is a professional and in-depth market ... industry. The report firstly reviews the basic ... application and manufacturing technology. The report then ... Oxybutynin Hydrochloride listing their product specification, capacity, ...
(Date:9/19/2014)... 2014 Research and ... addition of the "Global Gynecological Devices ...      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ... into wide categories based on their operations. ... of different gynecological conditions that affect the ...
(Date:9/19/2014)... , September 19, 2014 ... Market by Equipment (Cryotherapy, Heat, therapy, Hydrotherapy), Accessories (Posture ... Users (Hospitals), Advanced technologies - Global Forecast to ... is poised to reach $19,786.3 Million by 2019 ... of 6.8% from 2014 to 2019. ...
Breaking Medicine Technology:Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 2Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 3Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 4Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 5Global Gynecological Devices Market 2014-2018: Key Vendors are Bayer, Boston Scientific, CooperSurgical, Ethicon, Hologic, Medtronic, Olympus and Stryker 2Global Gynecological Devices Market 2014-2018: Key Vendors are Bayer, Boston Scientific, CooperSurgical, Ethicon, Hologic, Medtronic, Olympus and Stryker 3Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 2Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 3Physiotherapy Equipment Market Worth $19,786.3 Million by 2019 4
... Luminex Corporation (Nasdaq: LMNX ) today announced that ... 2011 on Monday, May 9, 2011. A press release announcing ... trading. (Logo:   http://photos.prnewswire.com/prnh/20100104/LUMINEXLOGO ) ... highlights and financial results for the first quarter ended March ...
... Measuring the body temperatures of newborns with temporal artery ... by axillary (under arm) thermometry, the clinically recommended method ... to a new study reported in Advances in ... first published clinical analysis evaluating the accuracy of temporal ...
Cached Medicine Technology:Luminex Corporation First Quarter Earnings Release Scheduled for May 9, 2011 2Luminex Corporation First Quarter Earnings Release Scheduled for May 9, 2011 3Study Finds Exergen Temporal Artery Thermometry Accurate on Newborns 2Study Finds Exergen Temporal Artery Thermometry Accurate on Newborns 3
The cementless acetabular shells form part of the Mallory head range of femoral and acetabular implants....
The Trilogy system builds on the success of the Harris/Galante Porous and HGP II cups by combining proven features with new technology designed to inhibit the formation and migration of polyethylene ...
The Secur-Fit cups incorporate enhancements derived from years of clinical, radiographic, and implant retrieval observations....
The Bofor acetabular revision cup addresses cases of severe acetabular destruction....
Medicine Products: