Navigation Links
Cancer vaccine combination therapy shows survival benefit in breast cancer
Date:5/15/2012

tients."

The article, available online, is titled "L-BLP25 vaccine plus letrozole induces a TH1 immune response and has additive antitumor activity in MUC-1 expressing mammary tumors in mice."

Breast cancer is the second-leading cause of cancer death in women in the United States, following lung cancer. Most cases of breast cancer are "estrogen-dependent" and respond to hormonal therapy. For tumors that are independent of hormonal influence, treatment options are limited and would especially benefit from a new treatment strategy such as a vaccine.

The vaccine was found to work best when the tumor burden -- the amount of cancer present -- was low, indicating that the vaccine may one day be best used as a preventative measure for women at high risk of developing breast cancer or for treatment of early disease.

Vaccine therapy is a promising new cancer-fighting strategy; the first therapeutic vaccine for prostate cancer was approved by the U.S. Food and Drug Administration in 2010. Trials with L-BLP25 vaccine are currently under way for lung and pancreatic cancers, whose cells also express altered MUC1, the same tumor-associated antigen found on breast cancer cells. The current study is the first known to the authors to demonstrate that a hormonal therapy combined with a vaccine provides additive antitumor activity and survival benefit.

"This was a true alliance between academics and industry," added DeGregorio, who noted that trials such as this one are especially expensive because of the number of mice needed and the length of time -- about three and a half years -- required to establish their findings. The study had support from the pharmaceutical company, Merck KGaA Darmstadt Germany.

DeGregorio's group will further test the vaccine with other conventional therapies and determine optimal dosing. Clinical trials in patients with breast cancer are in the planning stages.


'/>"/>

Contact: Dorsey Griffith
dorsey.griffith@ucdmc.ucdavis.edu
916-734-9118
University of California - Davis Health System
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study highlights need for coordination of care in stage 2 and 3 rectal cancer treatment
2. John Theurer Cancer Center hosting 8th Annual Neuro-Oncology Symposium
3. Study examines BI-RADS and MRI in predicting breast cancer
4. Early biomarker for pancreatic cancer identified
5. Fertilizing bone marrow helps answer why some cancers spread to bones
6. Genetic test identifies eye cancer tumors likely to spread
7. Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
8. Drug kills cancer cells by restoring faulty tumor suppressor
9. Mayo Clinic researchers discover biomarkers for prostate cancer detection, recurrence
10. Common Blood Pressure Drugs May Not Cut Colon Cancer Risk
11. Blood pressure drugs dont protect against colorectal cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... the April issue of Immunity , Kevin J. ... Research, says it,s time to take a fresh look ... sepsis, which kills millions worldwide every year, including more ... into the bloodstream to fight an injury or infection ... maintaining good health without inflammation, wounds and infections ...
(Date:4/17/2014)... A Northwestern University synthetic biology team has created ... create programmable therapeutics that could travel the body ... disease. , Engineering cell-based, biological devices that monitor ... in clinical synthetic biology. However, no existing technology ... a patient,s physiological state and respond in a ...
(Date:4/17/2014)... Il. (April 17, 2014) Doctors who treat ... called lymphangioleiomyomatosis (LAM) can face an agonizing treatment ... of the disease and help relieve shortness of ... transplants, and sirolimus can cause potentially fatal complications ... pulmonologist Dr. Daniel Dilling, medical director of Loyola ...
(Date:4/17/2014)... NEW YORK, NY (April 16, 2014) The cause ... but a new study proposes that neurons may be ... own immune system, similar to the way autoimmune diseases ... attack the body,s cells. The study was published April ... is a new, and likely controversial, idea in Parkinson,s ...
(Date:4/17/2014)... 2014 By discovering a new mechanism that allows ... researchers at UC Irvine and the Salk Institute have ... or prevent stroke-induced brain damage. , A complex and ... death and primary reason for disability in the U.S. ... and lets blood-borne material into the brain, causing the ...
Breaking Medicine News(10 mins):Health News:Feinstein Institute researcher publishes new perspective on sepsis 2Health News:Building 'smart' cell-based therapies 2Health News:Patients with rare lung disease face agonizing treatment dilemma 2Health News:Patients with rare lung disease face agonizing treatment dilemma 3Health News:Is Parkinson's an autoimmune disease? 2Health News:Study IDs new cause of brain bleeding immediately after stroke 2
... new study led by Fox Chase Cancer Center radiation ... scores determined by pathologists at Fox Chase Cancer Center ... scores from referring institutions. She presented the new ... Society for Radiation Oncology on Monday, October 3. ...
... busy," and "too complicated." These are the typical excuses ... they fail to use online error-reporting systems designed to ... Johns Hopkins investigators found instead that the most common ... trouble and embarrassment. Investigators e-mailed an anonymous survey ...
... the parents of women with polycystic ovary syndrome (PCOS) are more ... a hormonal disorder affecting about 10% of women of reproductive age. ... women and a leading cause of infertility. The study shows ... form of cardiovascular disease, and almost twice as likely to have ...
... severe 2009 H1N1 influenza who developed respiratory failure and were ... blood had a lower rate of in-hospital death than similar ... study appearing in JAMA . The study is being ... European Society of Intensive Care Medicine meeting in Berlin. ...
... HealthDay Reporter , TUESDAY, Oct. 4 (HealthDay News) -- ... fare just as well if they are released the same day ... new research shows. "[Discharging patients the same day] wasn,t ... Rao, lead author of a study appearing in the Oct. 5 ...
... News) -- ,Raw sewage contains thousands of undiscovered viruses, ... study suggests. Viruses are everywhere, but only about ... this study, researchers looked for the genetic signatures of ... and Africa. They detected the signatures of 234 known ...
Cached Medicine News:Health News:Fox Chase Gleason scores better predict prostate cancer's recurrence after radiation 2Health News:Fox Chase Gleason scores better predict prostate cancer's recurrence after radiation 3Health News:Survey reveals reasons doctors avoid online error-reporting tools 2Health News:Oxygenating system associated with lower risk of death for H1N1 patients with respiratory failure 2Health News:Oxygenating system associated with lower risk of death for H1N1 patients with respiratory failure 3Health News:Overnight Stay May Not Be Necessary for Stenting: Study 2Health News:Overnight Stay May Not Be Necessary for Stenting: Study 3Health News:Raw Sewage a New Frontier for Scientists 2
(Date:1/15/2014)...  According to Millennium Research Group (MRG), the global ... the United States and European transcatheter ... moderately through 2022, with embolization particles representing one ... in drug-eluting beads (DEBs) and radioembolization spheres in ...
(Date:1/15/2014)... , Jan. 15, 2014 ... research report is available in its ... Markets and Technologies for Advanced Drug ... of Administration ...
(Date:1/14/2014)... InformEx, North America,s leading business ... hold the 30 th edition of its annual conference ... from January 21-24. (Logo: http://photos.prnewswire.com/prnh/20131028/NY05330LOGO-a ) ... chemical and specialty chemical companies will take part in the ...
Breaking Medicine Technology:US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 16Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2
PRINCIPLE: The QC-SLIDES™ are specifically designed microscope slides intended to be part of the quality control program to monitor microbiological stains and staining techniques....
... KWIK-QC Slides have a positive and negative ... inoculation. With these slides, perform QC and ... enhance their education and training programs by ... interpretation, all on one slide! KWIK-QC slides ...
Microbiology QC Slides come with one or two droplets of an air-dried and methanol-fixed microorganism, or a single smear containing a designated microorganism population....
... Well Plate Capability The Equalizer 384 ... Equalizerexpandable and equal tip spacing, choice of two ... In addition, this model allows you to evenly ... and accessing many gels and for use with ...
Medicine Products: