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Cancer vaccine Special Focus series published in Human Vaccines & Immunotherapeutics
Date:8/27/2012

August 27, 2012 -- In one of the most comprehensive peer-reviewed discussions on cancer vaccines and immunotherapeutics, a Special Focus in the journal Human Vaccines & Immunotherapeutics provides a critical view on cancer vaccines and a discussion on best approaches for the future. From firsthand accounts of principal investigators involved in numerous failed cancer vaccine programs, including Oncophage and MVAX, to commentary from world experts in cancer vaccine development, authors in the Special Focus recount the mistakes of the past and provide an critical lens into the future of cancer vaccines with a potential for success.

Of special consideration is the technological advancement in Second Generation DNA sequencing technology that has resulted in the vast amount of genetic data of tumor cells gathered over the past few years. According to authors in the Special Focus, these data confirm that the degree of antigenic heterogeneity of tumor cells has been greatly underestimated. Tumors, once thought to be made of homogeneous collections of cells, are actually comprised of cells that carry an extreme diversity of antigens, the molecular signatures that are responsible for triggering immune response against cancer. This influences the important area of Antigen Discovery, a major criteria of vaccine formulation.

"Due in large part to genomic sequencing data, it has become quite clear that cancer is a heterogeneous disease and thus cannot be treated by homogeneous therapies. Many past cancer vaccine programs were based on the false premise of tumor homogeneity," said Michael G. Hanna, Jr., Ph.D., guest editor and contributor in the Special Focus series. "With all that we have learned at both the tumor genomic and immunotherapeutic levels, it is essential to reevaluate the antigen discovery process. The use of the patient's own tumor is the purest means to obtain a robust tumor-specific immune response."

The promise of trigger
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Contact: Betsy Granger
hv@landesbioscience.com
Human Vaccines & Immunotherapeutics, Landes Bioscience
Source:Eurekalert

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