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Cancer treatment, artery repair are goals of $3 million in NIH grants
Date:2/18/2014

arterial walls, with a significant risk of subsequent complications, such as re-narrowing of the artery or blood clot," Yang said.

Platelets accumulate on the damaged vessel, initiating clot formation. Other cells can deposit on the damaged vessel wall, building up a blockage. The result is multiple traumatic angioplastic and stenting procedures.

The researchers propose to develop a polymer nanoparticle that mimics platelets in the blood that form the clot and create a cover over the damage. Their nanoparticle is decorated with a molecule called GP1b peptide that links to the injured vessel wall and with an anti-CD34 antibody that catches the circulating endothelial progenitor cells that can grow into mature endothelial cells. Over time, the nanoparticles will degrade harmlessly as the new blood vessel lining repairs the damage, avoiding the need for a stent.

A surgeon will still do angioplasty first, according to Yang, but not put in a stent. The nanoparticle solution will be injected instead.

"Once our nanoparticles attach to the vessel wall, the platelets cannot attach," Yang said. "The nanoparticles can outperform the platelets for vessel wall binding due to their smaller sizes. Then the nanoparticles will catch the circulating endothelial progenitor cells to repair the injured vessel wall.

Once their missions are done, the nanoparticles will simply disappear without causing any long-term toxicity. These injectable nanoparticles have worked well in animal models in studies with our collaborators at UT Arlington."


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Contact: A'ndrea Elyse Messer
aem1@psu.edu
814-865-9481
Penn State
Source:Eurekalert

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