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Cancer therapy -- Nanokey opens tumors to attack
Date:11/14/2012

bsequently treated with Doxil the researchers observed, in real time, that the drug became concentrated in the tumor tissue. Indeed, in some cases, the combination was sufficient to bring tumor growth to a standstill, even in animals that had already undergone three cycles of treatment. This finding suggests that drug resistance, which often limits the efficacy of chemotherapy, does not develop in this context.

In addition to eliminating the primary tumor, a successful therapy must be able to kill metastatic tumors in other tissues. When the researchers looked at mice with neuroblastoma, or mice carrying implanted human colon tumors that had metastasized to the liver, they found that the new treatment strategy also significantly reduced the growth of metastases. "TNFα might also be useful in combination with other agents and other treatment regimens," says Ogris. "We now plan to optimize our gene delivery system, and hope that we can soon begin to plan preclinical tests of the new approach." (suwe)


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Contact: Kathrin Bilgeri
kathrin.bilgeri@lmu.de
49-892-189-6938
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

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