Navigation Links
Cancer therapy -- Nanokey opens tumors to attack
Date:11/14/2012

metastases."

A new strategy employing gene therapy could provide a solution to this problem. The idea is to deliver the gene for TNFα directly and specifically to the tumor cells. If this worked, the tumor cells themselves could produce and secrete the cytokine, ensuring that its local concentration becomes sufficiently high to permeabilize the blood vessels only in the immediate vicinity of the tumor. "We first designed a version of the TNFα gene that allows for the production of large amounts of the protein," Dr. Baowei Su, first author on the study, explains.

Shielding the drug from the organism

In collaboration with researchers at the Technische Universitt Mnchen and the Helmholtz Center Munich, the LMU team constructed a form of the gene which, in contrast to the normal version, is unlikely to induce non-specific inflammation. The plasmid was then incorporated into special nanoparticles, which not only protect the DNA from inactivation during its journey through the bloodstream, but also allow it to be targeted to the tumor. Experiments carried out on cell cultures confirmed that tumor cells treated with these particles synthesize large amounts of TNFα.

Treatment with the loaded nanoparticles alone, however, had only a moderate effect on tumor cells, but when they were administered in combination with the DNA-intercalating drug doxorubicin, the impact on tumor cell growth was markedly enhanced. Under the trade name Doxil, doxorubicin, which inhibits DNA replication, is available in a liposome-encapsulated form. Incorporating the drug into liposomes of 100 nm in diameter reduces side-effects and increases its half-life in the circulation, making it more effective than unencapsulated formulations.

No evidence for drug resistance

When mice with neuroblastoma, or mice that had received a xenograft of a human liver tumor, were first exposed to nanoparticles carrying the TNFα gene and su
'/>"/>

Contact: Kathrin Bilgeri
kathrin.bilgeri@lmu.de
49-892-189-6938
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. New Stool Test Might Aid in Early Detection of Colon Cancer
3. Study reveals how cancer drug causes diabetic-like state
4. How a cancer drug leads to diabetes
5. You Survived Cancer: Now Pay Attention to Your Overall Health
6. New drug prevents spread of human prostate cancer cells
7. Eliminating the good cholesterol receptor may fight breast cancer
8. Taller, Heavier Women May Face Higher Ovarian Cancer Risk
9. Experimental Chemo Combo for Colon Cancer Disappoints
10. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
11. Targeted therapeutics for colon cancer to be presented at AACR meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... PA (PRWEB) April 18, 2015 "I ... evacuation stretchers in healthcare facilities," said an inventor from ... alternative storage system." , He developed the Slyde Door ... doors used in healthcare facilities. It provides convenient storage ... there are more stretchers available for patients. , ...
(Date:4/18/2015)... has released a new blog post explaining how to ... , Drivers can find accurate information about various auto ... website can help drivers compare the newest and best ... whole process is designed to be convenient, free and ... quotes is advantageous because it allows clients to find ...
(Date:4/18/2015)... On April 14th, 2015, Symantec released Volume 20 ... “exposes a tactical shift by cyberattackers.” With everything from frightening ... 2014 - almost a million a day - to how ... and patched by prominent manufacturers – as long as 204 ... a digital world can be fraught with peril, and that ...
(Date:4/17/2015)... Heritage Woods of McLeansboro, a Gardant ... Week Celebration on April 20 with a day full ... body and soul. , The community, which is located ... adults of all incomes, including those on Medicaid, who ... Living Week is observed every April and highlights the ...
(Date:4/17/2015)... Canadian, Oklahoma (PRWEB) April 17, 2015 ... and Drug Dependence (NCADD) notes that drinking and driving ... attention. At the same time, the link between ... such as domestic abuse and violence and sexual assault, ... , According to the NCADD, 5.3 million adults in ...
Breaking Medicine News(10 mins):Health News:Auto Insurance Quotes Can Provide Accurate Results! 2Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 2Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 3Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 4Health News:Cyber Attackers Continue to Fine Tune Deception and Stealth Tactics According to New Report 5Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 2Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 3Health News:Narconon Arrowhead Raises Awareness on Alcohol Related Prevention 2Health News:Narconon Arrowhead Raises Awareness on Alcohol Related Prevention 3
... up four days of talks in Istanbul devoted to two ... how do you measure it? ,Experts attending a ... that the indices used in the past, which depended basically ... Product, were no longer valid. ,"Because we measure ...
... Health has shut down the beaches in some provinces ... past two weeks showed higher than acceptable levels of ... (KFLA) Public Health inspectors closed the beach to swimmers ... two weeks. Chenier said the highest results that came ...
... team in Israel has given Girls as young as 5 ... after chemotherapy. ,Doctors have extracted, matured and ... parents when they grow up. ,Childhood cancers usually ... but the aggressive chemotherapy which is often needed can render ...
... extended its smoking ban to entertainment outlets including pubs, ... to cut tobacco-related diseases. ,The ban ... the city-state which already has some of the toughest ... to restrict smoking in entertainment outlets is a natural ...
... lower AIDS figures but also to announce a six-fold jump ... next five years, officials say. ,Almost three ... will be poured into the next stage of India's HIV/AIDS ... a top official said. ,Previous estimates from India's ...
... (CSIRO), the Australia's national science agency, says it has ... people live to 100 years. ,The test, hailed ... of damage to a person's DNA and can point to ... in life. ,It will also allow doctors to ...
Cached Medicine News:Health News:Experts in Istanbul Seek Nature and Measure of Happiness 2Health News:Beaches Shut Due to High E-coli Level in Water 2Health News:Girls With Cancer Given Fertility Hope 2Health News:Singapore Extends Smoking Ban to Pubs, Nightclubs 2Health News:India AIDS Cases Due to Drop, Spending Up 2Health News:A Blood Test Developed in Australia to Repair DNA Damage 2
(Date:4/17/2015)... Australia , April 17, 2015 Bionomics ... discovery and development of innovative therapeutics for the treatment ... today announced the presentation of data from three of ... Association for Cancer Research (AACR) 106 th Annual ... Philadelphia, PA USA. ...
(Date:4/16/2015)... , April 16, 2015  Hologic, Inc. (NASDAQ: ... cancer screening study i published on-line this ... journal of the American Cancer Society. ... the University of Pittsburgh Medical Center, supports current consensus guidelines ... that women 30-65 years of age be co-tested ...
(Date:4/16/2015)... FLINT, Mich. , April 16, 2015  Diplomat ... of Shannon Beltrand to their senior leadership ... Beltrand will be responsible for securing and properly monitoring ... is secure both internally and externally. Additionally, she will ... planning. "We are very excited to ...
Breaking Medicine Technology:Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 2Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 3Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 4Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 5Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 2Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 3Hologic Comments on Important Cervical Cancer Screening Study Published in the American Cancer Society Journal, Cancer Cytopathology 4Diplomat Names Shannon M. Beltrand as New CISO 2
... Cargill today announced encouraging preliminary results from its ... head of beef cattle.  Initial results are based upon ... company,s Fort Morgan, Colo., beef processing facility where vaccinated ... Addressing the food and feed safety ...
... Nov. 15, 2010 Breathe Technologies, manufacturer of devices ... has appointed Lawrence A. Mastrovich as the new President ... us a phenomenal wealth of experience and strategic guidance," ... visible and instrumental role in building value within the ...
Cached Medicine Technology:Cargill Encouraged by Preliminary Results From Beef Cattle Vaccine Trial 2Cargill Encouraged by Preliminary Results From Beef Cattle Vaccine Trial 3Breathe Technologies Appoints New CEO 2
Exo-Deluxe Overhead Traction for hospital or home care. Twice the clearance of other units between the patient and supporting wall. 2" nylon pulleys with polypropylene cord, head halter, spreader bar...
Wonderflex™ is a lined soft durometer silicone gel sheet. It is ideal for cushioning orthotic/prosthetic devices and offers protection from shock and sheer forces. Wonderflex can also be lamina...
Designed to provide relief from chronic or acute back pain by unloading pressure off the lumbar discs and shifting pressure to the abdominal region...
Effectively stabilize and relax your back with the LumboTrain back support....
Medicine Products: