Navigation Links
Cancer therapies from the ocean?
Date:7/7/2008

Scientists from Aberdeen, Luxembourg and the South Pacific have studied the properties of natural products derived from animals found in Fijian waters, and shown that not only may certain compounds have potential use in anti-cancer therapies, but others may also be useful for improving drug delivery, currently one of the most significant problems faced by medical researchers. Professor Marcel Jaspars from the University of Aberdeen will present insights into these new compounds on Monday 7th July at the Society for Experimental Biology's Annual Meeting in Marseille [Session P2].

The team has focussed on finding compounds which interfere with a protein termed NF-kB. This particular protein is known to have a critical role in many types of cancer, as well as a number of other diseases including inflammatory bowel disease, arthritis and asthma, so there is a major drive to find molecules which can inhibit its activity. "We have tested a large number of marine species to see which can prevent NF-kB from working," explains Professor Jaspars. "A few animals, including sponges, soft corals and sea lilies, were examined further, and from these we have been able to isolate and characterise the compounds responsible. We have shown that one of these molecules is able to allow normal cell death (which NK-kB switches off in some cancerous cells) to start up again, a property which we will be going onto study in much more detail."

There is another possible application of molecules isolated from marine creatures that has the potential to have just as great an impact on the development of new medicines: "It is an unfortunate reality that currently, many new excellent drugs are discovered that cannot be delivered effectively to the places where they are required," Professor Jaspars reveals. "However, we have isolated one compound from a Mediterranean sponge that may help to end this trend. This molecule can reversibly create pores in cell membranes, a property for we envisage vast possibilities in the transportation of medicinal drugs. As we can now make this compound in the lab in large quantities, we are now able to investigate possible applications of the molecule, including drug delivery into tumours, gene delivery for cystic fibrosis and delivery of drugs into the eye."


'/>"/>

Contact: Holly Astley
hma25@cam.ac.uk
44-77928-55-259
Society for Experimental Biology
Source:Eurekalert

Related medicine news :

1. New ovarian stimulation technique offers more cancer patients the chance to preserve their fertility
2. Kidney Cancer Vaccine Shows No Boost in Survival
3. Susan G. Komen for the Cure(R)s Circle of Promise to Mobilize African American Women Against Breast Cancer at 2008 Music Festival
4. Circulating tumor cells can reveal genetic signature of dangerous lung cancers
5. Blood vessel inhibitor shows promise against metastatic thyroid cancer
6. New Drug Slows Thyroid Cancer
7. Circulating Tumor Cells Reveal Insights Into Lung Cancers
8. Smokeless Tobacco Products Do Raise Cancer Risk
9. DiagnoCures GCC marker for the staging of colorectal cancer discussed at the Eastern Cooperative Oncology Group
10. Designer diet for prostate cancer
11. Analysis of cancer incidence, mortality and survival combined reveals encouraging European trends
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/9/2016)... ... December 09, 2016 , ... ... The Pierre Hotel in New York, NY, on December 3rd, to benefit Holy ... physicians attended the annual event, which raised over $1 million - the largest ...
(Date:12/8/2016)... ... December 08, 2016 , ... The West Virginia ... 1, 2017. The name change aligns the entire company with its existing ... care quality. , “We are very proud of the achievements associated with the ...
(Date:12/8/2016)... ... December 08, 2016 , ... ZyDoc , ... Processing–Enabled and Conventional Data Capture Methods for Input to Electronic Health Records: A ... Results of the comparative usability study demonstrate that a dictation-based method (“NLP Entry”) ...
(Date:12/8/2016)... ... December 08, 2016 , ... With the increasing demand ... “What’s In Your Mouth?” (WIYM) campaign to inform dentists and patients about the safety ... dental implant and prosthetic market in the U.S. is projected to reach $6.4 billion ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... version gives development continuity to its innovative Unified Instance Manager architecture, meeting ... In addition, this new version optimizes the unattended auto-dialing system without agents, ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... 2016 True Health Diagnostics today announced ... services and management expertise to hospital systems throughout ... more doctors and patients to benefit from state-of-the-art ... Logo - http://photos.prnewswire.com/prnh/20161208/447162LOGO ... pressure to contain costs, have struggled to keep ...
(Date:12/8/2016)... -- Information products and services provider Elsevier ... , the world,s largest abstract and citation database of peer-reviewed literature, ... from over 5,000 publishers. The new set of metrics will improve ... when to adjust a journal,s editorial strategy. ... , , CiteScore ...
(Date:12/8/2016)... 2016 A Small Business Innovative Research (SBIR) ... Health (NIH) to Phoenix -based NeuroEM ... The grant will seek to determine an optimal set ... electromagnetic waves to treat Alzheimer,s Disease. The grant will ... possibly treat other neurologic disorders such as Parkinson,s Disease ...
Breaking Medicine Technology: