Navigation Links
Cancer therapies from the ocean?
Date:7/7/2008

Scientists from Aberdeen, Luxembourg and the South Pacific have studied the properties of natural products derived from animals found in Fijian waters, and shown that not only may certain compounds have potential use in anti-cancer therapies, but others may also be useful for improving drug delivery, currently one of the most significant problems faced by medical researchers. Professor Marcel Jaspars from the University of Aberdeen will present insights into these new compounds on Monday 7th July at the Society for Experimental Biology's Annual Meeting in Marseille [Session P2].

The team has focussed on finding compounds which interfere with a protein termed NF-kB. This particular protein is known to have a critical role in many types of cancer, as well as a number of other diseases including inflammatory bowel disease, arthritis and asthma, so there is a major drive to find molecules which can inhibit its activity. "We have tested a large number of marine species to see which can prevent NF-kB from working," explains Professor Jaspars. "A few animals, including sponges, soft corals and sea lilies, were examined further, and from these we have been able to isolate and characterise the compounds responsible. We have shown that one of these molecules is able to allow normal cell death (which NK-kB switches off in some cancerous cells) to start up again, a property which we will be going onto study in much more detail."

There is another possible application of molecules isolated from marine creatures that has the potential to have just as great an impact on the development of new medicines: "It is an unfortunate reality that currently, many new excellent drugs are discovered that cannot be delivered effectively to the places where they are required," Professor Jaspars reveals. "However, we have isolated one compound from a Mediterranean sponge that may help to end this trend. This molecule can reversibly create pores in cell membranes, a property for we envisage vast possibilities in the transportation of medicinal drugs. As we can now make this compound in the lab in large quantities, we are now able to investigate possible applications of the molecule, including drug delivery into tumours, gene delivery for cystic fibrosis and delivery of drugs into the eye."


'/>"/>

Contact: Holly Astley
hma25@cam.ac.uk
44-77928-55-259
Society for Experimental Biology
Source:Eurekalert

Related medicine news :

1. New ovarian stimulation technique offers more cancer patients the chance to preserve their fertility
2. Kidney Cancer Vaccine Shows No Boost in Survival
3. Susan G. Komen for the Cure(R)s Circle of Promise to Mobilize African American Women Against Breast Cancer at 2008 Music Festival
4. Circulating tumor cells can reveal genetic signature of dangerous lung cancers
5. Blood vessel inhibitor shows promise against metastatic thyroid cancer
6. New Drug Slows Thyroid Cancer
7. Circulating Tumor Cells Reveal Insights Into Lung Cancers
8. Smokeless Tobacco Products Do Raise Cancer Risk
9. DiagnoCures GCC marker for the staging of colorectal cancer discussed at the Eastern Cooperative Oncology Group
10. Designer diet for prostate cancer
11. Analysis of cancer incidence, mortality and survival combined reveals encouraging European trends
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/30/2016)... ... April 30, 2016 , ... Dr. Trevor Gardner, President of ... signed a multifaceted agreement which will allow for the research and development of ... Natural and Applied Sciences, Allied Health and Nursing will work together to develop ...
(Date:4/30/2016)... Santa Rosa, CA (PRWEB) , ... April 30, 2016 , ... “Aging well is a challenge for all of us, ... says NCMA’s Dr. Parul T. Kohli . “Research is showing more and more that ... the risk of disease and disability as we age.” Top priorities Dr. Kohli’s recommends for her ...
(Date:4/29/2016)... ... April 30, 2016 , ... World ... the Pick Up Springboard, an automotive invention that improves the storage features of ... worth $162 billion," says Scott Cooper, CEO and Creative Director of World Patent ...
(Date:4/29/2016)... ... April 29, 2016 , ... In an article published ... her enthusiasm for Botox and lip injections, which she underwent in order to feel ... Valley Music and Arts Festival. The article explains that Ms. Mirmelli’s situation is not ...
(Date:4/29/2016)... Fl (PRWEB) , ... April 29, 2016 , ... ... recently notified by the Accreditation Council for Graduate Medical Education (ACGME) that it ... , This is the first accreditation of three residency programs that Memorial is ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... , April 28, 2016   Click here ... Pharmacy, Inc. (NYSE: DPLO), the nation,s largest independent ... a definitive agreement to acquire Valley Campus Pharmacy, ... ("TNH"), a leading specialty pharmacy that provides individualized ... California . In 2015, TNH generated approximately ...
(Date:4/28/2016)...  Marking its one year anniversary since launching ... risk test, Color Genomics announced a ... impact the most common hereditary cancers affecting both ... analyzes hereditary cancer risks for breast, colorectal, melanoma, ... Color Test is physician ordered and includes genetic ...
(Date:4/28/2016)... , April 28, 2016 ... consumer insights on healthcare, announced today that it has ... report Cool Vendor in Life Sciences, 2016, ... 15, 2016.  The report focuses on life-science- oriented analytics, ... insight from patients and doctors, confirm medication ingestion, and ...
Breaking Medicine Technology: