Navigation Links
Cancer survivors at greater risk of birth complications; special monitoring needed
Date:7/1/2009

Amsterdam, The Netherlands: Survivors of childhood cancer run particular risks when pregnant and should be closely monitored, the 25th annual conference of the European Society of Human Reproduction and Embryology heard today (Wednesday 1 July). Dr. Sharon Lie Fong, of the Department of Obstetrics and Gynaecology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands, said that, although such women may have conceived spontaneously and considered themselves to be perfectly healthy, their deliveries should always take place in a hospital.

Dr. Lie Fong and colleagues studied data on the pregnancies of 40 women who had been treated for cancer during their childhood, the majority of them for leukaemia, but also for solid tumours. Six had had radiation treatment directly to the abdomen. The data were compared with those from a control group of more than 9,000 women who had not had cancer treatment. All data were obtained from The Netherlands Perinatal Register, a nationwide database of pregnancy outcomes. Data were matched for age at pregnancy, year and month of delivery, and the number of times the woman had given birth.

"This is the first such study on pregnancy outcome in childhood cancer survivors as compared with normal, healthy women," said Dr. Lie Fong. "Although we found no differences between most of the survivors and the control group, the women treated with abdominal radiotherapy delivered more prematurely. These women also had more postpartum haemorrhages the loss of more than one litre of blood after delivery."

The team did not investigate overall fertility and miscarriage rates, but they believe that it is possible that the fertility of all the cancer survivors may be compromised. "We know that radiotherapy and some chemotherapy treatments are toxic to the ovarian follicles," said Dr. Lie Fong, "and, in an earlier study, we had already found that ovarian reserve is smaller in adult survivors of childhood cancer than in age-matched controls."

The ovarian reserve, or capacity of the ovary to provide eggs capable of fertilisation, is established in the foetus and decreases during a woman's reproductive lifetime. Women with a poor ovarian reserve are less likely to conceive, even with assisted reproduction therapies, than those with a normal number of eggs. They may also have an earlier menopause, as their stock of eggs is exhausted at a younger age.

Long-term, multi-disciplinary follow-up for female child cancer survivors is mandatory, the researchers say. Although at the start of treatment, future fertility may not be of great concern to care providers, it is to the patient's parents. And during follow-up, survivors should be made aware of the possible late effects of their treatment.

In addition to the deleterious effects of abdominal radiotherapy on reproductive function, radiotherapy to the head can also cause problems by causing the hypothalamus to reduce the production of follicle stimulating hormone and luteinizing hormone, both important in promoting ovulation. "We believe that it is particularly important for all female children who are treated for cancer, and their parents, to be made aware of this risk. Our research has also shown how important it is that, if they do become pregnant, childhood cancer survivors should be closely monitored throughout their pregnancy and that they are delivered in a clinical setting, rather than at home."

The researchers say that even if at first fertility seems normal for childhood cancer survivors, there may be problems later in life. "We have yet to see whether the effects of cancer treatment include an earlier menopause," said Dr. Lie Fong, "and this possibility should be borne in mind when counselling these women on their reproductive options."


'/>"/>

Contact: Mary Rice
mary@mrcommunication.org
European Society for Human Reproduction and Embryology
Source:Eurekalert

Related medicine news :

1. Calling All Runners: Join the Fight Against Cancer
2. Study identifies biomarker that safely monitors tumor response to new brain cancer treatment
3. Lung Cancer Alliance Releases Updated 2009 Facts About Lung Cancer
4. Metabolic factors may play a role in risk for breast cancer
5. Possible benefit from online genetic testing for lung cancer
6. Metabolic Syndrome May Make Breast Cancer More Likely
7. Save the ta-tas Calling on Women to Join the Love/Avon Army of Women to Unlock the Key to Breast Cancer Prevention
8. Damon Runyon Cancer Research Foundation awards $2.7M to 7 top young clinical investigators
9. Bladder Cancer No Longer a Death Sentence
10. Peregrine Pharmaceuticals Completes Planned Patient Enrollment in Bavituximab Phase I Cancer Trial
11. AACE Response to Insulin Glargine Cancer Risk Articles in Diabetologia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2017)... , ... May 22, 2017 , ... Patients who avoid ... receive relaxing sedation dentistry in Mt. Kisco, NY from Advanced Endodontics of Westchester. This ... a variety of treatments. One or more sedation methods may be recommended based on ...
(Date:5/22/2017)... ... May 22, 2017 , ... An inventor from Columbia, ... a pen. "My wife’s hand was damaged in a firework accident, so she couldn’t ... people with manual problems." , He then designed and created a prototype for the ...
(Date:5/22/2017)... , ... May 22, 2017 , ... Faithfully following pop ... body squatted, stretched, jumped, toned and shaped through fitness programs. It carries on to ... course, finished off with an irresistible, radiant smile. CDA has found that ...
(Date:5/21/2017)... New York, NY (PRWEB) , ... May 19, 2017 , ... Chris Cornell, 52, was ... understand or imagine why one of the most respected lead singers in the rock industry ... had a history of mental illness. FindaTopDoc investigates how mental illness played a role in ...
(Date:5/21/2017)... ... May 20, 2017 , ... Pixel Film Studios presents ... use in Final Cut Pro X. The business-oriented elements and dignified animations are ... ProParagraph Corporate will deliver a professional and distinguished look to any multi-line text ...
Breaking Medicine News(10 mins):
(Date:5/18/2017)... , May 17, 2017  Bayer announced today ... portfolio will be presented at the 53 rd ... (ASCO), taking place June 2-6 in Chicago ... at ASCO span prostate, colorectal, liver and thyroid cancers, ... from the Phase II CHRONOS-1 trial of copanlisib in ...
(Date:5/10/2017)... 10, 2017 Hologic, Inc. (Nasdaq: ... the fiscal second quarter ended April 1, 2017 . ... increased 666.7% compared to the prior year period as ... a significant gain, while non-GAAP diluted EPS of $0.50 ... 3.8% in constant currency terms.  Excluding the effects of ...
(Date:5/9/2017)... 9, 2017 Zimmer Biomet Holdings, Inc. (NYSE ... today announced it has earned a spot on ... The Company was ranked among 500 U.S. employers as ... Healthcare Equipment and Services. The annual ... anonymous, independent survey of over 30,000 employees across 25 ...
Breaking Medicine Technology: