Navigation Links
Cancer stem cells are not 1 size fits all, lung cancer models show
Date:7/1/2010

Boston, Mass. - Cancer stem cells have enticed scientists because of the potential to provide more durable and widespread cancer cures by identifying and targeting the tumor's most voracious cells. Now, researchers at Children's Hospital Boston and their colleagues have identified cancer stem cells in a model of the most common form of human lung cancer and, more significantly, have found that the cancer stem cells may vary from tumor to tumor, depending upon the tumor's genetic signature.

"Our study shows the cancer stem cell hypothesis is true in some lung cancers," said senior author Carla Kim, PhD, an assistant professor in the Stem Cell Program at Children's Hospital Boston and the department of genetics at Harvard Medical School (HMS). "It also shows, from one lung cancer to another, the cancer stem cells are not the same."

Cancer stem cells are a subset of cancer cells believed to elude conventional treatments and eventually regenerate a tumor. Experimentally, they show up as cells that can be extracted from a tumor and transplanted to form a new tumor, from which the same tumor-propagating cells can again be extracted and transplanted with the same result. According to Kim, this is the first serial transplantation study to identify lung cancer tumor-propagating cells.

The findings, published in the July 2 Cell Stem Cell, connect the cancer stem cell hypothesis with molecular profiling of tumors (sometimes called personalized medicine). The results may allow researchers to combine stem cell biology with genetic typing to identify what drives the cancerous behavior of each patient's tumor and to develop new therapeutic targets.

In their study, Kim and her colleagues looked at mouse models of the three most commonly mutated genes in human lung cancer -- K-RAS and p53 (two genes predominantly mutated in adenocarcinomas of smokers) and one gene more often found mutated in non-smokers (EGFR). Led by HMS graduate
'/>"/>

Contact: Erin McColgan
erin.mccolgan@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Targeted therapy prolongs life in patients with HER2-positive breast cancer
2. New Drugs, New Combinations Fight Breast Cancer
3. Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
4. MDS Nordions TheraSphere(R) for Unresectable Liver Cancer (HCC) Now Covered by Two Large U.S. Insurers
5. National Oncologist Group Warns: Current Health Care Reform Legislation Woefully Short In Addressing Cancer Care Crisis
6. Panel calls for reducing colorectal cancer deaths by striking down barriers to screening
7. Lung Cancer: Large Impact, Little Funding
8. Inflammation marker related to obesity is elevated in patients with pancreatic cancer
9. Prolactin blocks oncogene associated with poor prognosis in breast cancer
10. Older female cancer survivors have added health issues compared to their counterparts
11. Definitive study confirms chemo benefit in postmenopausal breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... 2014 The North America Carotenoids & Antioxidants ... in North America with analysis and forecast of revenue. This ... 2012 to $812.7 million by 2018, at a CAGR of ... of the North America Carotenoids & Antioxidants Market report to ... provides a glimpse of the segmentation in the market, and ...
(Date:7/28/2014)... (HealthDay News) -- A common inflammatory muscle disorder ... may increase the risk for heart attack and ... study found that patients with polymyalgia rheumatica are ... that affect the blood vessels. Doctors should carefully ... polymyalgia rheumatica to reduce their risk for complications, ...
(Date:7/28/2014)... 2014 The Oneida Indian Nation today ... field of accompanying PGA TOUR players will be teeing ... Notah Begay III for the seventh annual Notah Begay ... Resort Casino ’s Atunyote® Golf Club on Wednesday, August ... Jason Dufner, Jimmy Walker, Jonas Blixt, Angel Cabrera and ...
(Date:7/28/2014)... 2014A two-step decision tree analysis, incorporating Donabedian,s model, ... the many available quality standards, guidelines, recommendations and ... international quality standards for radiation therapy, according to ... of Practical Radiation Oncology (PRO), the ... for Radiation Oncology (ASTRO). , Guidelines, recommendations and ...
(Date:7/28/2014)... (PRWEB) July 28, 2014 In response ... Americans face today, BlogHer, The Center for American Progress ... “Make Life Work,” a campaign to raise awareness and ... across the U.S. The joint initiative was announced on ... Editor-in-Chief, BlogHer; Judith Warner, Senior Fellow, The Center for ...
Breaking Medicine News(10 mins):Health News:North America Carotenoids & Antioxidants (Nutraceuticals) Market is Expected to Reach $812.7 Million in 2018 - New Report by MicroMarket Monitor 2Health News:North America Carotenoids & Antioxidants (Nutraceuticals) Market is Expected to Reach $812.7 Million in 2018 - New Report by MicroMarket Monitor 3Health News:North America Carotenoids & Antioxidants (Nutraceuticals) Market is Expected to Reach $812.7 Million in 2018 - New Report by MicroMarket Monitor 4Health News:Inflammatory Muscle Disorder May Raise Risk for Heart Attack, Stroke 2Health News:Turning Stone Announces that Tiger Woods and Fellow Golfing Elites Will Play at the Seventh Annual Notah Begay III Foundation Challenge 2Health News:Turning Stone Announces that Tiger Woods and Fellow Golfing Elites Will Play at the Seventh Annual Notah Begay III Foundation Challenge 3Health News:Turning Stone Announces that Tiger Woods and Fellow Golfing Elites Will Play at the Seventh Annual Notah Begay III Foundation Challenge 4Health News:Turning Stone Announces that Tiger Woods and Fellow Golfing Elites Will Play at the Seventh Annual Notah Begay III Foundation Challenge 5Health News:Two-step decision tree analysis helps inform updates of RT best practices, quality standards 2Health News:Two-step decision tree analysis helps inform updates of RT best practices, quality standards 3Health News:“Make Life Work” Campaign Launches to Address the Needs of Today's Working Families & Promote Realistic Solution 2Health News:“Make Life Work” Campaign Launches to Address the Needs of Today's Working Families & Promote Realistic Solution 3Health News:“Make Life Work” Campaign Launches to Address the Needs of Today's Working Families & Promote Realistic Solution 4Health News:“Make Life Work” Campaign Launches to Address the Needs of Today's Working Families & Promote Realistic Solution 5
... new government report shows, , WEDNESDAY, Aug. 19 (HealthDay News) ... 78 years, a record high, federal health officials said Wednesday. ... rate has dropped to an all-time low of 760.3 deaths ... U.S. Centers for Disease Control and Prevention. , "It is ...
... , , MINNETONKA, Minn., ... technology solutions company specializing in clinical study management systems, today ... named to the Inc. 5000, Inc . magazine,s annual ... rapid, yet controlled revenue growth over the last four years ...
... LEXINGTON, Ky., Aug. 19 VirtualHealth Technologies, Inc. (OTC Bulletin ... relation to the announcement made earlier this week on August 17th ... and restructuring fees as well as VHGI,s agreement to revise the ... of the August 17th release please go to http://www.virtu ...
... University have found exposure to the hormone progesterone activates ... This progesterone-induced inflammation may be a key factor ... is a naturally occurring steroid hormone and promotes development ... identified as a risk factor for breast cancer, and ...
... the University of Pittsburgh School of Medicine have shown that ... is required for their biological activity. This shape-changing also allows ... to select the structure that permits the best binding. That ... that will have the most impact on protein function to ...
... , ORLANDO, Fla., Aug. ... developed technology that has dramatically increased the stability and ... has just completed a 7-year shelf-life study of its ... supercritical CO2 extract of Haematococcus pluvialis, bolstered by Valensa,s ...
Cached Medicine News:Health News:Life Expectancy in U.S. Hits a New High 2Health News:Life Expectancy in U.S. Hits a New High 3Health News:MedNet Solutions Named to the Inc. 5000 List Three Years in a Row 2Health News:VirtualHealth Technologies Files 8k Related to the August 17th Announcement of Private Access Payment and Document Modification 2Health News:VirtualHealth Technologies Files 8k Related to the August 17th Announcement of Private Access Payment and Document Modification 3Health News:MSU scientists: Progesterone leads to inflammation 2Health News:Pitt scientists find intrinsic changes in protein shape influence drug binding 2Health News:Astaxanthin Stability Breakthrough Achieved by Valensa 2Health News:Astaxanthin Stability Breakthrough Achieved by Valensa 3
(Date:7/28/2014)... , July 28, 2014  Air Products (NYSE: ... of medical oxygen is vital to any healthcare facility. ... that not only improve the efficiency of its oxygen ... will highlight these systems—including systems for emergency oxygen ... loss—from August 4-5 at the 51 st ...
(Date:7/28/2014)... July 28, 2014  Array BioPharma Inc. (Nasdaq: ... the fourth quarter and full year of ... to discuss those results on Tuesday, August ... and Michael Carruthers , Chief Financial ... August 12, 2014Time:9:00 a.m. Eastern TimeToll-Free:(800) 708-4540Toll:(847) ...
(Date:7/28/2014)...  Houston dentist , Dr. Behzad ... with Invisalign. With access to this increasingly popular ... straightened without feeling self-conscious in the process. Invisalign ... types of braces, but patients who choose Invisalign ... better support for their oral health and comfort ...
Breaking Medicine Technology:Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 2Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 3Houston Cosmetic Dentist, Dr. Behzad Nazari, Now Offers Orthodontic Treatment with Invisalign 2
... the Academy of Managed Care Pharmacy (AMCP) 2010 ... week, Express Scripts (Nasdaq: ESRX ) ... for driving down healthcare costs and providing increased ... (Logo:   http://photos.prnewswire.com/prnh/20080827/EXPRESSSCRIPTSLOGO ) (Logo: ...
... DIEGO, Oct. 13 RESMED INC. (NYSE: RMD ... will release its results for the first quarter of fiscal ... ResMed,s results will be issued after 1:00 p.m. Pacific Time ... to review its results, market trends, and future outlook. ...
Cached Medicine Technology:Express Scripts Unveils New Opportunities to Drive Down Healthcare Costs; Presents Five Studies at Academy of Managed Care Pharmacy Conference 2Express Scripts Unveils New Opportunities to Drive Down Healthcare Costs; Presents Five Studies at Academy of Managed Care Pharmacy Conference 3ResMed Announces Conference Call and Webcast to Discuss First Quarter 2011 Results 2