Navigation Links
Cancer sequencing initiative discovers mutations tied to aggressive childhood brain tumors
Date:1/29/2012

Researchers studying a rare, lethal childhood tumor of the brainstem discovered that nearly 80 percent of the tumors have mutations in genes not previously tied to cancer. Early evidence suggests the alterations play a unique role in other aggressive pediatric brain tumors as well.

The findings from the St. Jude Children's Research Hospital Washington University Pediatric Cancer Genome Project (PCGP) offer important insight into a poorly understood tumor that kills more than 90 percent of patients within two years. The tumor, diffuse intrinsic pontine glioma (DIPG), is found almost exclusively in children and accounts for 10 to 15 percent of pediatric tumors of the brain and central nervous system.

"We are hopeful that identifying these mutations will lead us to new selective therapeutic targets, which are particularly important since this tumor cannot be treated surgically and still lacks effective therapies," said Suzanne Baker, Ph.D., co-leader of the St. Jude Neurobiology and Brain Tumor Program and a member of the St. Jude Department of Developmental Neurobiology. She is a corresponding author of the study published in the January 29 online edition of the scientific journal Nature Genetics.

DIPG is an extremely invasive tumor that occurs in the brainstem, which is at the base of the skull and controls such vital functions as breathing and heart rate. DIPG cannot be cured by surgery and is accurately diagnosed by non-invasive imaging. As a result, DIPG is rarely biopsied in the U.S. and little is known about it.

Cancer occurs when normal gene activity is disrupted, allowing for the unchecked cell growth and spread that makes cancer so lethal. In this study, investigators found 78 percent of the DIPG tumors had alterations in one of two genes that carry instructions for making proteins that play similar roles in packaging DNA inside cells. Both belong to the histone H3 family of proteins. DNA must be wrapped aroun
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Test Might Predict Risk of Lung Cancers Return
2. Discovery of new vaccine approach for treatment of cancer
3. Statins May Stave Off Liver Cancer in People With Hepatitis B
4. Researchers Spot Potential Bile Duct Cancer Drug Targets
5. Too Few Americans Getting Screened for Common Cancers: CDC
6. Scripps research scientists illuminate cancer cells survival strategy
7. Georgetown Lombardi researchers present new findings on head & neck cancers
8. JTCC brings leading experts to present 2011 San Antonio Breast Cancer Symposium research
9. New Queens University research sheds light on gene destruction linked to aggressive prostate cancer
10. Radiation plus chemotherapy provides long-term positive results for head and neck cancer patients
11. Oral HPV infection, HPV-related cancers more common in men
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/2/2014)... Dr. Ping Hu is a worldly educated and ... from the Capital Medical University in Beijing, China and ... from the University of London. She completed her ... and finished her fellowship at the University of Illinois ... both inside and outside of the classroom with her ...
(Date:8/2/2014)... When the Black Hat conventioneers descend on Las ... thing can be always counted on, plenty of FUD will ... and doubt. The run-up has already made its share ... Reuters on July 31st about how hackers could use ... successfully infect a system with malware, completely undetected, by leveraging ...
(Date:8/1/2014)... 02, 2014 The successful development of ... business of Guangdong FODAY Automobile Co.,LTD. As early as ... had already organized an excellent team to develop a ... detailed, in-depth technical plans. The company’s vice president Liming ... the direct involvement of the specific arrangement and the ...
(Date:8/1/2014)... Cannabis use among young people has spiked, with ... used marijuana at least once and 17 percent admitting to ... Drugs, Say ‘Yes to Life,’ volunteers from the Church of ... with factual information about drugs, to help reverse this alarming ... to Drugs, Say ‘Yes’ to Life,” volunteers have distributed 40,000 ...
(Date:8/1/2014)... the University of California, San Diego School of Medicine ... chili peppers produces chronic activation of a receptor ... reaction that ultimately reduces the risk of colorectal tumors. ... 2014 issue of The Journal of Clinical Investigation ... was originally discovered in sensory neurons, where it acts ...
Breaking Medicine News(10 mins):Health News:Black Hat USA 2014 Will Again Stress Need for Security Basics with Glimpse of What May Lie Ahead 2Health News:Black Hat USA 2014 Will Again Stress Need for Security Basics with Glimpse of What May Lie Ahead 3Health News:Black Hat USA 2014 Will Again Stress Need for Security Basics with Glimpse of What May Lie Ahead 4Health News:Black Hat USA 2014 Will Again Stress Need for Security Basics with Glimpse of What May Lie Ahead 5Health News:FODAY Automobile Company Is Now Working On The C60F FODAY Project 2Health News:Addressing a Serious Issue Affecting German Teens 2Health News:Pepper and halt: Spicy chemical may inhibit gut tumors 2
... are smokers with implanted defibrillators had seven times higher a ... their heart into normal rhythm than nonsmokers with the device. ... School of Medicine in St. Louis .Eleven percent of cardiovascular ... that decreasing or quitting smoking is in itself a very ...
... A news study appearing in the June 15, 2006 ... Cancer Society, says that external beam radiation// could be ... years diagnosed with prostate cancer. ,Age has ... prostate cancer. In younger individuals, doctors recommend more aggressive ...
... was found that de- addiction drug help to combat alcoholism. ... Naltrexone//. This drug blocks craving for any sort of drug. ... American Medical Association. This drug can be made accessible ... of alcohol addicts. The two drugs that were tested are ...
... been warned against running long distances, as his health seems ... examined him//. ,The kid's clinical parameters such as ... are higher, according to Sugat Kar, Chief medical officer, Capital ... to have high blood pressure (135/85 mm Hg) and a ...
... the Human Fertility and Embryology Authority (HFEA) is evident that there ... a later age. Based on statistics it was seen that in ... or over. But in 2002, 24 babies were born to women ... NHS say that IVF should not be done to women over ...
... (IPF) is a disease whose cause and cure are not ... till date//. It is a lung disease characterized by scarring ... entire organ (lung). Statistics show that approximately 83,000 ... diagnosed every year. Ten years ago Jean Thompson became ...
Cached Medicine News:Health News:Jolt to Quit Smoking 2Health News:Slow Down Budhia, Warn Medical Experts 2Health News:Lesser Know Facts about Idiopathic Pulmonary Fibrosis (IPF) 2
(Date:8/1/2014)... 1, 2014 Dyadic International, Inc. ("Dyadic") (OTCQX: ... technologies are used to develop, manufacture and sell enzymes ... and industrial enzyme industries, announced today that it will ... June 30, 2014 after market close on Thursday, August ... day at 5:00 p.m. Eastern Time to discuss those ...
(Date:7/31/2014)... 2014  According to data released today by the ... monthly Medicare Part D premium is expected to remain ... originally projected, the Pharmaceutical Care Management Association (PCMA) said. ... be a bright spot in American health care. By ... and using cutting edge, cost-saving tools like pharmacy networks ...
(Date:7/31/2014)... RMD ) today announced results for its fourth ... Revenue for the quarter was $415.2 million, flat compared to ... on a constant currency basis). Net income was $87.7 million, ... June 30, 2013. Diluted earnings per share for the quarter ... quarter ended June 30, 2013.  The results ...
Breaking Medicine Technology:Dyadic International To Announce Second Quarter 2014 Financial Results And Host Conference Call On Thursday, August 14, 2014 2Dyadic International To Announce Second Quarter 2014 Financial Results And Host Conference Call On Thursday, August 14, 2014 3RESMED Inc. Announces Results for the Fourth Quarter and Fiscal Year 2014 2RESMED Inc. Announces Results for the Fourth Quarter and Fiscal Year 2014 3RESMED Inc. Announces Results for the Fourth Quarter and Fiscal Year 2014 4RESMED Inc. Announces Results for the Fourth Quarter and Fiscal Year 2014 5RESMED Inc. Announces Results for the Fourth Quarter and Fiscal Year 2014 6RESMED Inc. Announces Results for the Fourth Quarter and Fiscal Year 2014 7RESMED Inc. Announces Results for the Fourth Quarter and Fiscal Year 2014 8RESMED Inc. Announces Results for the Fourth Quarter and Fiscal Year 2014 9RESMED Inc. Announces Results for the Fourth Quarter and Fiscal Year 2014 10RESMED Inc. Announces Results for the Fourth Quarter and Fiscal Year 2014 11RESMED Inc. Announces Results for the Fourth Quarter and Fiscal Year 2014 12RESMED Inc. Announces Results for the Fourth Quarter and Fiscal Year 2014 13
... Reportlinker.com announces that a new market ... Triple Analysis: Lymphoma, Prostate ... http://www.reportlinker.com/p0284719/Triple-Analysis-Lymphoma-Prostate-Cancer-and-Antibodies.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=Pathology This triple analysis ... both Lymphoma and Prostate Cancer and by ...
... CYBX ), a global leader in epilepsy management, today ... Conference on Wednesday, June 8, 2011, in New York. ... Financial Officer, will speak to the attendees of the conference ... the presentation can be accessed by clicking on the Investor ...
Cached Medicine Technology:Reportlinker Adds Triple Analysis: Lymphoma, Prostate Cancer and Antibodies 2Reportlinker Adds Triple Analysis: Lymphoma, Prostate Cancer and Antibodies 3Reportlinker Adds Triple Analysis: Lymphoma, Prostate Cancer and Antibodies 4Reportlinker Adds Triple Analysis: Lymphoma, Prostate Cancer and Antibodies 5
Stainless steel bone clamp....
Designed for proximal femoral elevation in total hip replacement or in other surgery with a similar need for bone manipulation....
To elevate, dissect, scrape and apply traction to bone and soft tissue....
The AV Plus DX pacing lead is designed for use with the St. Jude Medical Affinity VDR pulse generator. This single-lead pacing system provides reliable pacing therapy with the added benefits of AV sy...
Medicine Products: