Navigation Links
Cancer scientists discover genetic diversity in leukemic propagating cells
Date:1/19/2011

(Toronto, Canada January 20, 2011) Cancer scientists led by Dr. John Dick at the Ontario Cancer Institute (OCI) and collaborators at St Jude Children's Research Hospital (Memphis) have found that defective genes and the individual leukemia cells that carry them are organized in a more complex way than previously thought.

The findings, published today in Nature (DOI:10.1038/nature09733), challenge the conventional scientific view that cancer progresses as a linear series of genetic events and that all the cells in a tumour share the same genetic abnormalities and the same growth properties.

"Our results show this is not the case and open the way to discover how genetic abnormalities transform normal cells into leukemic cells and the steps that have to happen to make the leukemic cells increasingly abnormal and aggressive, how leukemic cells at different steps of genetic evolution (or progression) respond to therapy, or contribute to relapse," says Dr. Dick, Senior Scientist at OCI's Campbell Family Institute for Cancer Research, the research arm of Princess Margaret Hospital, and the McEwen Centre for Regenerative Medicine at University Health Network. Dr. Dick is also a Professor in the Department of Molecular Genetics, University of Toronto, and Director of the Cancer Stem Cell Program at the Ontario Institute for Cancer Research.

The research team found that the leukemia cells taken from patients with acute lymphoblastic leukemia (ALL) are actually composed of multiple families of genetically distinct leukemia cells. They looked at how these families developed and retraced the ALL "family tree" back to its origins. They discovered that the so-called black sheep the cells that propagate the disease and potentially survive therapy persist through generations, and even branch off and evolve to form genetically distinct cancer families. Some of these genetic families dominate, making it appear that the leukemia cells onl
'/>"/>

Contact: Jane Finlayson
jane.finlayson@uhn.on.ca
416-946-2846
University Health Network
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Enhancing arrest of cell growth to treat cancer in mice
2. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
3. The National Coalition for Cancer Survivorship Joins the Commission on Cancer
4. Low forms of cyclin E reduce breast cancer drugs effectiveness
5. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
6. Soft drinks may increase risk of pancreatic cancer
7. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
8. Genes Play Role in Prognosis With Non-Small Cell Lung Cancers
9. Single gene mutation induces endometrial cancer
10. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
11. Molecular pathways linked to sex, age affect outcomes in lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... new analysis has found that rates of testicular cancer ... Hispanic American men, but not among their non-Hispanic counterparts. ... journal of the American Cancer Society, the findings indicate ... of testicular cancer in Hispanic adolescents and young adults, ... cause of this trend. , Testicular cancer is one ...
(Date:7/14/2014)... EurekaMag.com has newly published results of 64,900 ... disease that ranges in severity from a mild ... illness that attacks the liver. An estimated 3.2 million ... virus infection of which approximately 80% of people develop ... all studies on Hepatitis C , the Life, Earth ...
(Date:7/14/2014)... Wa (PRWEB) July 14, 2014 ... Violet Protocol book review recently updated by ... consists of a wide range of simple ... of endometriosis including:, ... meat and dairy products ,     Increasing ...
(Date:7/14/2014)... 2014 Carepoint has been designed ... by combining an intuitive interface for recording, sending, ... service tracking and reporting features. , Hall mc ... teamed up with Rebecca de Witte to create ... organizations. , Carepoint provides seamless, real-time ...
(Date:7/14/2014)... (PRWEB) July 14, 2014 Vaginal ... continues against seven different pelvic mesh manufacturers in the ... Wright & Schulte LLC. The federal complaints are pending ... No. 2327), American Medical Systems (MDL No. 2325), and ... 16th, there are 58,262 Vaginal Mesh lawsuit claims pending, ...
Breaking Medicine News(10 mins):Health News:Testicular cancer rates are on the rise in young Hispanic Americans 2Health News:EurekaMag.com Publishes 64,900 New Studies on Hepatitis C 2Health News:Endometriosis Bible and Violet Protocol Book Review Exposes Zoe Brown's Endometriosis Treatment Guide – Vkool.com 2Health News:Endometriosis Bible and Violet Protocol Book Review Exposes Zoe Brown's Endometriosis Treatment Guide – Vkool.com 3Health News:Home Health Care Professional and Marketing Firm Team Up to Create New Homecare Communication App 2Health News:Nearly 60,000 Vaginal Mesh Lawsuit Claims Filed Against Seven Different Pelvic Mesh Manufacturers 2Health News:Nearly 60,000 Vaginal Mesh Lawsuit Claims Filed Against Seven Different Pelvic Mesh Manufacturers 3Health News:Nearly 60,000 Vaginal Mesh Lawsuit Claims Filed Against Seven Different Pelvic Mesh Manufacturers 4Health News:Nearly 60,000 Vaginal Mesh Lawsuit Claims Filed Against Seven Different Pelvic Mesh Manufacturers 5
... Committee handed a major victory to the health care industry ... a "public option" to compete against private health insurance providers ... system. The industry has fought the public option with lobbying ... fearing that the proposed policy would cut into their record ...
... ROCKVILLE, Md., Sept. 30 The U.S. Food and ... Consumer Update videos. , (Logo: http://www.newscom.com/cgi-bin/prnh/20090824/FDALOGO ... , http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm182842.htm , ... Approximately 30,000 Americans go to the emergency room each ...
... Corporation ("Select") (NYSE: SEM ), the parent of Select ... public offering of common stock at a price of $10.00 ... Select,s stock began trading on the New York Stock ... Total net proceeds to Select from the offering, after deducting ...
... Simmons firm, a leading national law firm in the fight ... Miles for Meso 5K run/walk on Sunday, October 11, in ... www.milesformeso.org . , The Simmons firm ... in Alton, Ill. Nearly 500 runners and walkers registered, and ...
... ... ), a comprehensive New Jersey anti-poverty charity, is serving more than 500 hot meals ... Services Corp. ( http://www.servicer.com ) and Rapid Pump & Meter Service Co., Inc., ( ... , ...
... problems later , WEDNESDAY, Sept. 30 (HealthDay News) -- New ... reduces the risk for neurological problems later. , Unfortunately, the ... disability. , Still, the findings, appearing in the Oct. 1 ... help fill a crucial gap in the effort to treat ...
Cached Medicine News:Health News:Insurance Industry Successful in Initial Fight Against Public Option; Public Feels Left Out 2Health News:Insurance Industry Successful in Initial Fight Against Public Option; Public Feels Left Out 3Health News:FDA Consumer Health Information Updates: New Web Videos Educate Consumers About Food and Medical Product Safety 2Health News:Select Medical Holdings Corporation Successfully Completes Initial Public Offering of Common Stock 2Health News:Simmons Law Firm Presents Second 'Miles for Meso' Walk/Run Fundraiser for Mesothelioma Research 2Health News:A New Jersey Anti-Poverty Charity Meets a Crisis of Need with Charitable Giving from Local Paterson, NJ Small Businesses 2Health News:A New Jersey Anti-Poverty Charity Meets a Crisis of Need with Charitable Giving from Local Paterson, NJ Small Businesses 3Health News:A New Jersey Anti-Poverty Charity Meets a Crisis of Need with Charitable Giving from Local Paterson, NJ Small Businesses 4Health News:Cooling Helps Oxygen-Deprived Newborns 2Health News:Cooling Helps Oxygen-Deprived Newborns 3
(Date:7/11/2014)... 11, 2014 The consumer marketing playbook ... industry sectors to better identify winning tools and ... engage with and understand consumers, as new technologies ... critical purchasing decisions. According to ... one area where organizations can observe a deep ...
(Date:7/11/2014)... -- Research and Markets has announced the ... Film Industry Report 2014" report to their offering. ... Global And Chinese Medical X-Ray Film Industry Report 2014 ... state of the Global medical X-ray film industry with ... provides a basic overview of the industry including definitions, ...
(Date:7/11/2014)... , July 11, 2014 Research and ... Hypodermic Needles Market 2014-2018" report to their offering. ... A hypodermic needle is a hollow needle commonly used ... or or to extract fluids from it. A hypodermic ... to inject substances that cannot be ingested. Hypodermic needles ...
Breaking Medicine Technology:New Technologies Transforming Consumer Marketing Research Playbook 2Global and Chinese Medical X-ray Film Industry Report 2014 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 3
... River Systems, Inc. announces today that it has ... Massachusetts Institute of Technology (M.I.T.) to utilize advanced ... and Fusion Center in collaboration with Still River. ... with its own leading-edge developments in its groundbreaking ...
... 22, 2011 CardioFocus, Inc., developer of the HeartLight™ ... fibrillation (AF), announced today that its technology will be ... European Heart Rhythm Association (EHRA) EUROPACE 2011 congress, June ... is a unique catheter ablation technology that incorporates an ...
Cached Medicine Technology:Still River Systems Sign Patent License Agreement With the Massachusetts Institute of Technology 2CardioFocus HeartLight™ Endoscopic Ablation System to be Featured at EHRA EUROPACE 2011 2CardioFocus HeartLight™ Endoscopic Ablation System to be Featured at EHRA EUROPACE 2011 3
Solid steel construction for lifelong quality. Strong, smooth and quiet electro-mechanical up/down movement. Dual castor, locking wheels for use on carpet or tile flooring. Easy cleaning, deluxe lami...
Trial lens set +/- Cyl....
... control panel with 3 charging wells. Available ... Colonial Blue and Cinnamon. Spring balanced refractor ... and steel construction for lifelong quality. Sealed ... up/down chair movement. Chair back reclines manually ...
Our Ophthalmic Diagnostic Sets offer everything an eye care specialist needs. Complete your set with your choice of ophthalmoscope, retinoscope, handle, and case....
Medicine Products: