Navigation Links
Cancer risk for kidney transplant
Date:4/30/2010

Kidney transplant recipients are known to have a higher risk of cancer, compared to the general population, due to the need to take immunosuppressive drugs to prevent organ rejection. Results published today from a significant, long-term study suggest that no single medication appears to increase this cancer risk.

Evaluating data from 1983 in a randomised trial, researchers were able review trends among 481 patients over 20 years - providing the strongest evidence to date on the issue. A total of 226 patients in the trial developed at least one cancer. By 20 years post transplant, 27% of patients developed non-skin cancer and 48% of patients developed skin cancer no one treatment had a greater effect on cancer risk.

"We found that no particular immunosuppressive drug regimen appears to increase the risk of cancer among kidney transplant patients," said lead author Dr Martin Gallagher, The George Institute.

"What we did find is that the cancer risk is driven by many factors that are known at the time of transplantation such as age and smoking history, so that patients at especially high risk can be targeted at this time", he added.

The results, which were published today in the Journal of the American Society of Nephrology, reported that non-skin cancer was associated with increasing age and smoking history; skin cancer was associated with increasing age, non-brown eye color, fairer skin, and a functioning transplant. Therefore, patients at especially high risk can be monitored more closely and use preventive measures to protect against cancer.

"Much debate has focused on the effects of various agents and dose regimens, but our analysis would suggest that cancer risk is driven by total immune suppression rather than specific medications."

More than 11,000 Australians have received a kidney transplant in the last forty years. Kidney transplant survival rates are about 90% in the first year and over 75% in five years, which mean that most kidney recipients can look forward to many years of productive life. However, it is known that patients with a kidney transplant have a 2.5 3 times higher risk of cancer than the general population.

This research analysis was undertaken by researchers from The George Institute, the University of Sydney, The Children's Hospital at Westmead, and Royal Prince Alfred Hospital Statewide Renal Services using the ANZDATA Registry.


'/>"/>

Contact: Emma Orpilla
eorpilla@george.org.au
612-823-8242
Research Australia
Source:Eurekalert

Related medicine news :

1. Targeted therapy prolongs life in patients with HER2-positive breast cancer
2. New Drugs, New Combinations Fight Breast Cancer
3. Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
4. MDS Nordions TheraSphere(R) for Unresectable Liver Cancer (HCC) Now Covered by Two Large U.S. Insurers
5. National Oncologist Group Warns: Current Health Care Reform Legislation Woefully Short In Addressing Cancer Care Crisis
6. Panel calls for reducing colorectal cancer deaths by striking down barriers to screening
7. Lung Cancer: Large Impact, Little Funding
8. Inflammation marker related to obesity is elevated in patients with pancreatic cancer
9. Prolactin blocks oncogene associated with poor prognosis in breast cancer
10. Older female cancer survivors have added health issues compared to their counterparts
11. Definitive study confirms chemo benefit in postmenopausal breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... NY (PRWEB) , ... May 26, 2016 , ... ... founder of Mehling Orthopedics and chief medical officer of Blue Horizon International (BHI), ... and Regeneration. The conference was held during May 5-6, 2016 in Chicago, IL, ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... oncology professionals, has added National Cancer Institute-designated University of Virginia (UVA) Cancer ... this new partnership, OncLive’s editorial and marketing teams will publicize and promote public ...
(Date:5/26/2016)... ... May 26, 2016 , ... Metcalf & Associates’ ... 20 years of experience in leading technology and human resources operations for health ... teaching, Morrow-Fox will be featured on Metcalf’s VoiceAmerica radio show , Innovative ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... is seeking nominations to serve on its Accreditation and Standards Committees and ... “RadSite’s quality-benchmarking activities incorporate key process and outcome measures, with the ultimate ...
(Date:5/26/2016)... , ... May 26, 2016 , ... According to the ... an industry filled with chemical-laden beauty products, one company is going against the norm ... you: Mad Hippie. The rising star in the green space is proud to announce ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... 2016 Since its commercial introduction ... essential life science tool for conducting genetic studies in ... reveals in its new report that the industry sits ... powered by a range of new applications in the ... http://photos.prnewswire.com/prnh/20140723/694805 ) , Since the ...
(Date:5/25/2016)... GERMANTOWN, Maryland , May 25, 2016 /PRNewswire/ ... Frankfurt Prime Standard: QIA) today announced that the company has ... GmbH to develop and commercialize predictive assays in oncology. An ... a marker to predict effectiveness of anthracycline treatment in triple ... are pleased to partner with Therawis, which developed the PITX2 ...
(Date:5/25/2016)... As illustrated by the Spring ... the numbers and momentum of cannabis in the US ... billions, more research and development push the sector forward. ... Legal Marijuana Markets Report  from from ArcView Market Research ... the increase in sector is attributed to adult use ...
Breaking Medicine Technology: