Navigation Links
Cancer risk for kidney transplant
Date:4/30/2010

Kidney transplant recipients are known to have a higher risk of cancer, compared to the general population, due to the need to take immunosuppressive drugs to prevent organ rejection. Results published today from a significant, long-term study suggest that no single medication appears to increase this cancer risk.

Evaluating data from 1983 in a randomised trial, researchers were able review trends among 481 patients over 20 years - providing the strongest evidence to date on the issue. A total of 226 patients in the trial developed at least one cancer. By 20 years post transplant, 27% of patients developed non-skin cancer and 48% of patients developed skin cancer no one treatment had a greater effect on cancer risk.

"We found that no particular immunosuppressive drug regimen appears to increase the risk of cancer among kidney transplant patients," said lead author Dr Martin Gallagher, The George Institute.

"What we did find is that the cancer risk is driven by many factors that are known at the time of transplantation such as age and smoking history, so that patients at especially high risk can be targeted at this time", he added.

The results, which were published today in the Journal of the American Society of Nephrology, reported that non-skin cancer was associated with increasing age and smoking history; skin cancer was associated with increasing age, non-brown eye color, fairer skin, and a functioning transplant. Therefore, patients at especially high risk can be monitored more closely and use preventive measures to protect against cancer.

"Much debate has focused on the effects of various agents and dose regimens, but our analysis would suggest that cancer risk is driven by total immune suppression rather than specific medications."

More than 11,000 Australians have received a kidney transplant in the last forty years. Kidney transplant survival rates are about 90% in the first year and over 75% in five years, which mean that most kidney recipients can look forward to many years of productive life. However, it is known that patients with a kidney transplant have a 2.5 3 times higher risk of cancer than the general population.

This research analysis was undertaken by researchers from The George Institute, the University of Sydney, The Children's Hospital at Westmead, and Royal Prince Alfred Hospital Statewide Renal Services using the ANZDATA Registry.


'/>"/>

Contact: Emma Orpilla
eorpilla@george.org.au
612-823-8242
Research Australia
Source:Eurekalert

Related medicine news :

1. Targeted therapy prolongs life in patients with HER2-positive breast cancer
2. New Drugs, New Combinations Fight Breast Cancer
3. Study Finds Possible Explanation for the Link Between Infertility and Breast/Ovarian Cancer Risks
4. MDS Nordions TheraSphere(R) for Unresectable Liver Cancer (HCC) Now Covered by Two Large U.S. Insurers
5. National Oncologist Group Warns: Current Health Care Reform Legislation Woefully Short In Addressing Cancer Care Crisis
6. Panel calls for reducing colorectal cancer deaths by striking down barriers to screening
7. Lung Cancer: Large Impact, Little Funding
8. Inflammation marker related to obesity is elevated in patients with pancreatic cancer
9. Prolactin blocks oncogene associated with poor prognosis in breast cancer
10. Older female cancer survivors have added health issues compared to their counterparts
11. Definitive study confirms chemo benefit in postmenopausal breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... ... 2017 , ... The VA Maryland Health Care System and ... project focused on multiple sclerosis (MS). Led by Christopher M. Jewell, PhD, an ... disease without compromising normal immune function that often occurs during autoimmune diseases. Ultimately ...
(Date:1/18/2017)... Cranbury, NJ (PRWEB) , ... ... ... Times®, the specialty pharmacy industry‚Äôs leading journal and most-read publication among specialty ... Vanderbilt University Medical Center through its Strategic Alliance Partnership (SAP) program, announced ...
(Date:1/18/2017)... ... January 18, 2017 , ... A Palm Beach doctor ... Smile Train, an international charity that provides free surgery to poor children suffering from ... in the past I have run to support the efforts of the American Heart ...
(Date:1/18/2017)... , ... January 18, 2017 , ... The Portee Insurance ... families and business owners in central Maryland and the DC region, is inaugurating a ... kills 787,000 people nationally every year, making it the #1 killer in America. However, ...
(Date:1/18/2017)... ... , ... At Hallmark Nameplate, their commitment to quality is what sets them ... 13485. This certification is another way they are making constant strides to provide all ... need. , The ISO 13485 Certification is a major accomplishment for Hallmark Nameplate and ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... -- Aprima Medical Software, a leading provider of innovative ... revenue cycle management (RCM) solutions for medical practices, ... Healthcare Data Solutions (HDS) of Coral Cables, FL. ... full support for HDS,s customers, which include approximately ... states. Financial terms were not disclosed. ...
(Date:1/18/2017)... JOSE, Calif. , Jan. 18, 2017  Adaptive Sound ... announced today a new partnership with Hyatt Place Nashville/Downtown ... by providing ASTI LectroFan sleep therapy machines in over ... one of the most important parts of having a ... , general manager of Hyatt Place Nashville/Downtown. "We,re pleased ...
(Date:1/18/2017)... PUNE, India , January 18, 2017 According to ... Type and by Application: Global Opportunity Analysis and Industry Forecast, 2014 - 2022," ... expected to reach $1,127 million by 2022, growing at a CAGR of 8.26% ... share, in terms of revenue. Continue Reading ... ...
Breaking Medicine Technology: