Navigation Links
Cancer researcher receives $3.8 million award from US Department of Defense
Date:11/13/2008

(Santa Barbara, Calif.) A $3.8 million Innovator Award, from the Department of Defense, is being granted over five years to an internationally renowned cancer researcher at the University of California, Santa Barbara.

Erkki Ruoslahti, recipient of the award, is known for his innovative, interdisciplinary research. "This is a special award because there are only four of them," said Ruoslahti. "I am very happy at being chosen." The award is designed to further his current research.

Ruoslahti's lab made a major advance in the past year. "I think that was part of the reason why the grant was awarded to me, is that we can now make probes, typically peptides," he said. "These are small pieces of protein that not only bind the particles to the vessels in the tumor, but they also carry the particles into the interior of the tumor, outside the blood vessels."

He recently showed that targeting a nanoparticle drug into a tumor is more effective than if it isn't targeted. "What we are working on now, as an additional function, is that we'd like to make the particles respond to a signal so that they would release a drug when we want it to be released," he said. "But we haven't solved what would have to be done to get that technology to work."

"We work a lot with nanoparticles; that is one of the reasons why I am here at UCSB," said Ruoslahti. "There are a lot of materials scientists here who are collaborating with us in designing the smart nanoparticles that seek out and zero in on the tumor."

Tumors have and this is one of the main problems in chemotherapy, or any other kind of tumor therapy a very high interstitial pressure. That pushes tissue fluid from the tumor out to the surrounding tissue. "That means that if you just have a drug, that you would like to enter into a tumor, this flow of fluid works against it and tends to push it out," he said. "We have now solved that problem with our newest peptides. We can get nanoparticles or just plain drugs to go through the tumor as if there were no obstacles there."

At Burnham-UCSB, Ruoslahti opened the Vascular Mapping Center which focuses on developing applications for vascular "zip codes," based on technology discovered in his laboratory. Vascular zip codes are molecular signatures in blood and lymphatic vessels (vasculature) that are specific to individual tissues and disease sites. Ruoslahti has discovered ways to selectively target drugs to tumor blood vessels in mice and suppress the growth of those tumors. He has also found a way to selectively target the lymphatic vessels in tumors. The hope is that this very specific delivery of therapeutics to tumor blood and lymphatic vessels will increase the efficacy of cancer therapies and decrease side effects.

Ruoslahti joined the faculty at UCSB as an adjunct professor in the Department of Molecular, Cellular, and Developmental Biology in 2006. He is affiliated with The Burnham Institute for Medical Research, an institute that is located both at UCSB and in San Diego. This type of collaboration, involving a highly ranked university and a nonprofit, independent research institute, exemplifies the inherent value of interdisciplinary research and the enhanced potential created when two such entities join force. Ruoslahti also belongs to the faculty of UC San Diego as a distinguished professor.


'/>"/>

Contact: Gail Gallessich
gail.g@ia.ucsb.edu
805-893-7220
University of California - Santa Barbara
Source:Eurekalert  

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Survival differences by race most apparent in advanced stages of breast cancer
3. MRI finds breast cancer before it becomes dangerous
4. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
5. Pathway links inflammation, angiogenesis and breast cancer
6. Radiologists encouraged to look beyond cancer for clinically unseen diseases
7. Diet high in meat, fat and refined grains linked to risk for colon cancer recurrence, death
8. Immune deficiency linked to a type of eye cancer
9. Drop in breast cancer incidence linked to hormone use, not mammograms
10. Breast cancer prevention practices vary across Canada
11. First biomarker discovered that predicts prostate cancer outcome
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cancer researcher receives $3.8 million award from US Department of Defense
(Date:2/8/2016)... MD (PRWEB) , ... February 08, 2016 , ... ... is excited to share this important news! AHCC and the Home Health and ... Coding Clinic, CMS' designee for official ICD coding guidance and clarifications, to address ...
(Date:2/8/2016)... ... 2016 , ... The schedule is now online for the largest ... which is being held May 25-29 at the Loews Chicago O’Hare Hotel, continues to ... causes of chronic illness in children. , Very recent articles have cited 1 child ...
(Date:2/7/2016)... ... 2016 , ... HealthSmart Holdings, Inc. announced today the launch ... and information to lower the costs, and increase the impact of their healthcare ... healthcare benefits by as much as 22%:, + Price and quality transparency, ...
(Date:2/6/2016)... ... ... With the FCPX LUT: Summer pack from Pixel Film Studios, ... is a Lookup Table that contains a mathematical formula for modifying an image. The ... manipulating each pixel, LUT's can change each color range differently, it gives the user ...
(Date:2/5/2016)... ... February 05, 2016 , ... Love is in the ... a variety of colors, assortments and packaging. This staple for Valentine’s Day is a ... location. , For Valentine’s Day, not only are long-stem roses available, but also ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)...  Redwood Scientific Technologies, Inc. announced today the development ... women balance their hormones. This product will be featuring ... Jason Cardiff , President and CEO. "I am proud ... millions of women across the country and around the ... Our research and development team is confident that through ...
(Date:2/5/2016)... , Feb. 5, 2016  ivWatch, a medical devices company, ... STEM Award granted by Governor Terry McAuliffe,s office. ... on February 25th at an event to be held at ... STEM award honors professionals and business that have made significant ... Logo - http://photos.prnewswire.com/prnh/20160205/330117LOGO ...
(Date:2/5/2016)... in Alabama seeking prostate care with ... have to travel out of state. Vituro Health ... of Alabama to provide a total prostate management program ... Alabama is known throughout the ... using many different modalities. They are the largest and one ...
Breaking Medicine Technology: