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Cancer requires support from immune system to develop, UT Southwestern researchers report
Date:10/30/2008

urgically because too many blood vessels were involved. Because Gleevec is already approved for other conditions, the girl's doctor treated her under "compassionate use" guidelines.

The girl's tumor shrank by 70 percent with no apparent side effects during the first three months of a six-month treatment under "compassionate use" regulations. The mass has remained dormant in the six months afterward, the researchers reported.

While this was only a single case, it was consistent with the one-year study of the tumor and its action in mice, Dr. Parada said, and the child's treatment was tailored to reflect the findings from the animal study.

A phase 2 clinical trial of this treatment in people with neurofibromatosis has been approved and is under way.

Dr. Parada cautioned, however, that further research is needed. A single human case, while encouraging, is not enough to prove the long-term effectiveness of the treatment, and Gleevec might be exerting other actions in addition to inhibiting mast cells.


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Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

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Cancer requires support from immune system to develop, UT Southwestern researchers report
Cancer requires support from immune system to develop, UT Southwestern researchers report
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