Navigation Links
Cancer-related protein may play key role in Alzheimer's disease
Date:2/28/2008

Tampa, FL (Feb. 27, 2008) -- The cancer-related protein Akt may profoundly influence the fate of the tau protein, which forms bundles of tangled nerve cell fibers in the brain associated with Alzheimers disease, reports a new study led by researchers at the University of South Florida and the Mayo Clinic in Jacksonville, FL.

The study was published online Feb. 21 in the early edition of the Proceedings of the National Academy of Sciences. The findings may provide another piece of the puzzle in figuring out how tau proteins can poison nerve cells in the brain.

Akt is known to increase cancer cell survival capability and has become a target in the development of some cancer-inhibitor drugs. The abnormal accumulation of tau protein tangles kills nerve cells and is considered one of the hallmarks of Alzheimers disease.

This study describes for the first time a new function for the cancer-related protein Akt one that may help promote Alzheimers disease pathology, said lead author Chad Dickey, PhD, assistant professor of molecular pharmacology and physiology at USF. We found that increased amounts of Akt may prevent the removal of abnormal proteins, such as tau, causing these proteins to accumulate and disrupt the balance within the cells.

While this Akt-induced imbalance might result in cancer cells continuing to divide uncontrollably, Dr. Dickey suggests it likely has a different effect in Alzheimers disease. The nerve cells may try to divide in the brain, but cannot, and therefore die, he said. Thus regulating levels of Akt, rather than its activity, may be beneficial to sufferers of diseases of aging, such as cancer, Alzheimers and even diabetes.


'/>"/>

Contact: Anne DeLotto Baier
abaier@health.usf.edu
813-974-3300
University of South Florida Health
Source:Eurekalert  

Page: 1

Related medicine news :

1. Exercise and psychological counseling could ease cancer-related fatigue
2. Draining away brains toxic protein to stop Alzheimers
3. Penn study finds pro-death proteins required to regulate healthy immune function
4. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
5. Emory researchers identify signaling protein for multiple myeloma
6. Human C-reactive protein regulates myeloma tumor cell growth and survival
7. Lowering Blood Protein Wont Help Kidney Patients
8. Blood protein detects lung cancer, even at earliest stage
9. Natural Protein Could Help Spot, Treat Liver Cancer
10. Heat shock proteins are co-opted for cancer
11. How adhesive protein causes malaria
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cancer-related protein may play key role in Alzheimer's disease
(Date:6/27/2017)... ... June 27, 2017 , ... The Kelahan Agency, a ... to residents of southern New Hampshire, is teaming up with the New Horizons ... and homelessness in the region. , New Horizons for New Hampshire provides a ...
(Date:6/27/2017)... ... , ... Dr. Richard Amato, a respected periodontist in Monroe, CT, ... Implant Center of Connecticut. As part of the renovation, the cutting-edge practice added two ... to improve patient comfort while making it possible for Dr. Amato to provide even ...
(Date:6/27/2017)... ... 2017 , ... East Los Angeles dentist, Ramin Assili DDS , comments ... happens to a woman during pregnancy can have profound effects on a developing fetus, ... on a baby’s long-term health. This study, which was performed at the University of ...
(Date:6/26/2017)... California (PRWEB) , ... June 26, 2017 , ... ... of Male Fertility & Sexual Medicine Specialists, in collaboration with the Fertility Center ... for male fertility care: PESA (percutaneous epidydimal sperm aspiration) and TESA (percutaneous testicular ...
(Date:6/26/2017)... ... , ... LARKR™ , an innovative new smartphone app providing on-demand talk ... to join its online treatment platform. , Launching in just a few days, ... number of people in need nationwide, and to supplement their traditional practices. Joining this ...
Breaking Medicine News(10 mins):
(Date:6/8/2017)... , June 8, 2017   Responding to Heath ... and the death of singer Chris Cornell in ... Rights International offers a free online psychiatric ... consumers and families about psychotropic drug risks. ... who died from an accidental overdose, has called for tighter ...
(Date:6/7/2017)... Md. , June 7, 2017  Novavax, Inc., (Nasdaq: ... second of two Phase 2 trials of its RSV F ... of child bearing age have been published in the journal ... publication have been shared in prior scientific conferences). The Company ... in April 2014. Novavax is developing the RSV F Vaccine ...
(Date:6/5/2017)... , June 5, 2017 Kohll,s Pharmacy ... the United States . The Raizer is ... a fallen person up to an almost-standing position ... and operated by one assistant and does not ... is simple enough that a child can operate it, ...
Breaking Medicine Technology: