Navigation Links
Cancer prevention: stopping cancer before it can start
Date:4/14/2008

ng said the dose used in this study was low and the benefits should outweigh the risks.


Dietary energy balance impacts spontaneous pancreatic lesions in the K5.COX-2 transgenic model of pancreatic cancer: Abstract 4188

Shedding light on the links between obesity and cancer, researchers at the University of Texas M. D. Anderson Cancer Center report that modulating energy balance by restricting calories can prevent pancreatic cancer in laboratory models.

We are very excited that our research may lead to insights to prevent or control this deadly disease in the near future, said lead researcher Laura M. Lashinger, Ph.D., a post-doctoral fellow at M. D. Anderson.

Pancreatic cancer is the fourth leading cause of cancer death in both men and women in the United States. Obesity, the overall rate of which has risen sharply over the past 40 years, has emerged in epidemiological studies as a key risk factor for pancreatic cancer.

Other studies have shown that calorie restriction, a dietary strategy for inducing negative energy balance and preventing or reversing obesity, has significant anticancer effects in several species, against a variety of tumor types. However, the exact mechanisms underlying the obesity-pancreatic cancer association are not clearly understood.

It is likely that inflammation may be playing a role, Lashinger said. Fat tissue is more than simply weight; it produces an inflammatory property that leads to greater risk of cancer and other diseases.

In the current study, Lashinger and colleagues hypothesized that spontaneous tumor development in the K5.COX-2 transgenic mouse model of pancreatitis-driven pancreatic cancer would be reduced in lean mice, when compared with overweight or diet-induced obese mice.

They placed 36 mice on one of three diets for 14 weeks: a lean diet with a 30 percent calorie restriction (n = 12), an overweight diet (n = 12), or a hig
'/>"/>

Contact: Staci Vernick Goldberg
Staci.goldberg@aacr.org
267-646-0616
American Association for Cancer Research
Source:Eurekalert

Page: 1 2 3 4 5 6 7

Related medicine news :

1. Detecting, Diagnosing Breast Cancers
2. Calorie restriction inhibits, obesity fuels development of epithelial cancers
3. Stem Cell Marker Controls Pair of Key Cancer Pathways
4. Celebrex Plus Lipitor Could Fight Prostate Cancer
5. Celebrex-Lipitor combo may halt prostate cancer
6. Georgetown researchers find stem cell marker controls 2 key cancer pathways
7. Blood pressure drugs halt pancreatic cancer cell growth, Jefferson researchers find
8. Calorie restriction limits and obesity fuels development of epithelial cancers
9. Allegro Diagnostics Announces Publication in Cancer Prevention Research of Prediction Model for Lung Cancer Diagnosis Integrating Clinical and Genomic Features
10. NovoCure presents results from breast cancer pilot study
11. Jefferson scientists discovery may help explain smoking-pancreatic cancer link
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... (PRWEB) July 28, 2014 Evolve Medical Clinics ... 2014, offering its members virtual visits and dramatic operational changes ... , Some estimates state that as many as 70% of ... “Imagine not having to leave your office or home for ... blood pressure or cholesterol,” CEO and Founder Michael R. Freedman, ...
(Date:7/28/2014)... 28, 2014 Ticket Down is ... Champions Cup Match between Manchester City and Liverpool FC ... Bronx has hosted countless big events since it opened several ... of the original Yankee Stadium, however, it has been a ... City metro area. , The Yankees Stadium is the ...
(Date:7/28/2014)... Scottsdale, Ariz (PRWEB) July 28, 2014 ... closed on a new camp property in Cornville, ... provides seriously ill children with the opportunity to ... the campers and families. The organization offers a ... ages 6-15 with chronic and life threatening illnesses ...
(Date:7/28/2014)... Quincy Bioscience, makers of the nation’s ... announce the release of the fourth edition of The ... Mark Underwood. , The Brain Health Guide is a ... for readers to improve memory and promote optimal aging. ... Brain Health Guide provides ways to help minimize common ...
(Date:7/28/2014)... Randy Dotinga HealthDay Reporter ... know it takes humans just milliseconds to look at someone,s ... a new study finds that certain facial features seem to ... The shape and size of the mouth, for example, appear ... are keys to attractiveness. The study findings suggest ...
Breaking Medicine News(10 mins):Health News:Evolve Medical Clinics to Open First Next Generation Primary and Urgent Care Facility 2Health News:Evolve Medical Clinics to Open First Next Generation Primary and Urgent Care Facility 3Health News:Evolve Medical Clinics to Open First Next Generation Primary and Urgent Care Facility 4Health News:Liverpool FC vs. Manchester City Tickets at Yankee Stadium: Ticket Down Reports Huge Demand for Guinness International Champions Cup Tickets in NYC 2Health News:Liverpool FC vs. Manchester City Tickets at Yankee Stadium: Ticket Down Reports Huge Demand for Guinness International Champions Cup Tickets in NYC 3Health News:Camp Soaring Eagle Announces New Camp Site 2Health News:Camp Soaring Eagle Announces New Camp Site 3Health News:Quincy Bioscience Launches the Fourth Edition of The Brain Health Guide 2Health News:Facial Dimensions May Be Key to First Impressions 2Health News:Facial Dimensions May Be Key to First Impressions 3
... The Men,s Health Policy,Center, a new resource center ... that they are hosting an online petition urging,Congress ... Services (CMS) practice,that unfairly restricts prostate cancer patients, ... people who are impacted by prostate cancer to,raise ...
... The Richard B. and,Lynne V. Cheney Cardiovascular ... have joined the Institute,s Board of Directors. As ... Institute., "Mary Matalin,s experience in public affairs ... Institute as we build our organization and educate,communities ...
... Have Choices and Flexibility ... Typically Available on Larger Plans, NEW YORK, March ... employees can now choose from a wider selection of dental ... The Guardian Life Insurance Company of America (Guardian), a ...
... 27, 2008 The Cardiovascular Research Foundation (CRF) will ... mortality rates for drug-eluting stents (DES) versus bare metal ... tomorrow evening in Chicago. , The analysiswhich includes ... team of researchers led by Ajay J. Kirtane, MD, ...
... relaxation response, a stress-management approach, to other lifestyle ... of hypertension most common in the elderly. ... Massachusetts General Hospital (MGH) Hypertension Program and the ... who received relaxation response training in addition to ...
... There is new promise on the horizon for ... according to researchers at the University of Toronto. ... twitches and muscle contractions during rapid eye-movement (REM) sleep, ... at the University of Toronto, discovered that an inhibitory ...
Cached Medicine News:Health News:Men's Health Policy Center Hosts Petition to Protest Government Barrier to Prostate Cancer Medications 2Health News:Mary Matalin and John Ray Join the Cheney Cardiovascular Institute Board of Directors 2Health News:Guardian Expands Dental Benefit Options Helps Small Business Owners Lower Insurance Cost 2Health News:Guardian Expands Dental Benefit Options Helps Small Business Owners Lower Insurance Cost 3Health News:Largest ever analysis of DES data demonstrates safety, efficacy in on-and-off-label use 2Health News:Relaxation training may improve control of hard-to-treat systolic hypertension 2Health News:Relaxation training may improve control of hard-to-treat systolic hypertension 3
(Date:7/28/2014)... 28, 2014  Air Products (NYSE: APD ... oxygen is vital to any healthcare facility. This understanding ... only improve the efficiency of its oxygen supply systems, ... these systems—including systems for emergency oxygen supply ... 4-5 at the 51 st ASHE Annual ...
(Date:7/28/2014)... BIRMINGHAM, Ala. , July 28, 2014 /PRNewswire-USNewswire/ ... Arthur J. Tipton , Ph.D., President and CEO ... of the Controlled Release Society (CRS) for the ... Society,s annual meeting on July 12 in ... than 40 countries.  The Controlled ...
(Date:7/28/2014)... , July 28, 2014  A prospective study ... Sweden has validated the performance of ... and has associated volumetrically assessed breast density measurements ... Epidemiology, Biomarkers & Prevention (DOI: 10.1158/1055-9965.EPI-13-1219), the ... tool for widespread breast cancer risk assessment," was ...
Breaking Medicine Technology:Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 2Air Products Highlights Its Medical Oxygen Supply Systems for Emergency Oxygen Supply and Reduced Oxygen Loss at ASHE 3Arthur J. Tipton, Ph.D., Named President of Controlled Release Society 2Arthur J. Tipton, Ph.D., Named President of Controlled Release Society 3Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 2Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 3Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers 4
... 26, 2012  Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) today ... year 2011 financial and operating results on Thursday, February 16, ... host a conference call at 8:30 AM EST that day. ... be webcast online simultaneously.  A link to the webcast may ...
... PARK, N.J., Jan. 26, 2012  Armada Health Care, ... a joint development and marketing agreement that will ... specialty pharmacy software. Armada is a leading group ... providing services such as web-based therapy management and ...
Cached Medicine Technology:Regeneron to Report Full Year 2011 Financial and Operating Results and Host Conference Call and Webcast on February 16, 2012 2Armada Health Care and Definitive Homecare Solutions Announce Alliance for Specialty Pharmacy Software and Services 2Armada Health Care and Definitive Homecare Solutions Announce Alliance for Specialty Pharmacy Software and Services 3
... new Finnpipette Focus from Thermo ... combine ergonomics with uncompromising performance. ... plate offers a custom fit ... new shorter tip cones allow ...
... The Eppendorf Reference Series 2000 Pipette is ... stroke, a compact and robust design, and ... is used to operate the measuring stroke ... tip. Product features:Eppendorf "pipette/tip" system ensures utmost ...
Inquire...
... precision, ergonomics, and value!, Comfortable ... soft non-slip, contoured handle , Finer ... plunger spring action , Completely autoclavable ... the need for recalibration , Easy-to-read ...
Medicine Products: