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Cancer prevention: stopping cancer before it can start
Date:4/14/2008

celecoxib and were followed for another two years to assess safety and effectiveness. Even after two years off medication, the five-year rate of advanced adenoma was reduced by 41 percent among patients taking the lower dose and 26 percent among patients taking the higher dose.

Cardiovascular events were more common in patients taking celecoxib, with a rate of 3.8 percent among those patients taking placebo to 6 percent among the low dose group and 7.5 percent among the high dose group. However, when researchers looked at factors that might predict cardiovascular complications, they found a much different story.

For patients with no cardiovascular risk factors before using celecoxib, the rate of cardiovascular adverse events was 0.9 percent in the placebo group, 3.9 percent in the 400 mg group and 1.9 percent in the high dose group. Cardiovascular risk factors included smoking, high cholesterol, high blood pressure, diabetes, presence of atherosclerosis and age over 65.

If a patient had one risk factor, the risk was 2.2 percent in the placebo group, 3.7 percent in the 400 mg dose group and 4.9 percent in the high dose group.

The greater cardiovascular risk was observed among patients who had at least two cardiovascular risk factors at the time they entered the study, where the placebo group had a 5.9 percent risk, the 400 mg group had an 8.2 percent risk and the 800 mg group had an 11.2 percent risk.

This new data allows us to carefully select patients who can benefit from this drug, Bertagnolli said. Although it should be used with caution, those patients with a high risk for colon cancer and a low risk for cardiovascular disease are going to receive significant benefit.


Inhibition of androgen-independent growth of LNCaP xenograft tumors in immunodeficient mice by a combination of atorvastatin (Lipitor) and celecoxib (Celebrex): Abstract 2100

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Contact: Staci Vernick Goldberg
Staci.goldberg@aacr.org
267-646-0616
American Association for Cancer Research
Source:Eurekalert

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