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Cancer prevention: stopping cancer before it can start
Date:4/14/2008

SAN DIEGO Tapping into a growing body of knowledge about the origins and progression of cancer, researchers are now developing and testing new preventive therapies to stop it in its tracks. At the 2008 Annual Meeting of the American Association for Cancer Research, April 12-16, researchers present data on the preventive effects of celecoxib and atorvastatin and vitamin D in colorectal, prostate and breast cancer, respectively, and the relationship between diet, metabolism and the development of pancreatic cancer.


The Adenoma Prevention with Celecoxib (APC) trial: Five-year efficacy and safety results: Abstract LB-141

Colon adenoma prevention with celecoxib, a non-steroidal anti-inflammatory drug (NSAID), is effective and can be safe for patients without underlying cardiovascular risk factors, according to five-year data of a randomized phase III trial.

There has been a significant amount of negative press about Cox-2 inhibitors including celecoxib, and clearly these drugs are risky for some patients. However, our study also shows that for patients without major cardiovascular risk factors, celecoxib at low doses protects against high-risk lesions that can lead to colon cancer, said Monica Bertagnolli, M.D., associate professor of surgery at the Brigham and Womens Hospital.

Bertagnolli was the lead researcher on the Adenoma Prevention with Celecoxib (APC) trial, which enrolled 2,035 patients and randomly assigned them to 200 mg twice-daily (400 mg) of celecoxib, 400 mg twice-daily (800 mg) of celecoxib or a placebo group.

At three years, patients taking celecoxib at 400 mg had a 29 percent reduction in adenomas, a precursor to colon cancer, while those taking 800 mg had a 38 percent reduction. Advanced adenomas, which are lesions with a high-risk for cancer development, were reduced by 55 percent with 400 mg and 63 percent with 800 mg.

After three years, patients stopped taking
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Contact: Staci Vernick Goldberg
Staci.goldberg@aacr.org
267-646-0616
American Association for Cancer Research
Source:Eurekalert

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