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Cancer predisposition from genetic variation shows strong gender bias
Date:9/21/2009

ptible to an environmental challenge than those that don't. The compound was administered orally to female mice.

"When they delivered the compound, the lifespan of the mice was reduced significantlythey developed breast cancer as well as other types of cancers," Stambrook says. "In addition, the mice that harbored this variant were more susceptiblein other words, they developed tumors more quickly than wild-type mice."

Stambrook says that by learning more about the signaling pathway of the CHEK2 gene, researchers can explore ways to "rescue" it and identify potential therapeutic targets.

"It's an interesting gene," says Stambrook, "and there are a lot of interesting directions that this finding will take us."


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Contact: Keith Herrell
keith.herrell@uc.edu
513-558-4559
University of Cincinnati Academic Health Center
Source:Eurekalert

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