Navigation Links
Cancer predisposition from genetic variation shows strong gender bias
Date:9/21/2009

CINCINNATICancer predisposition resulting from the presence of a specific gene variant shows a strong gender bias, researchers at the University of Cincinnati (UC) have demonstrated.

In addition, the research indicates that the risk for development of cancer in individuals harboring the gene variant can be further increased as a result of environmental exposure.

Peter Stambrook, PhD, a professor in the department of molecular genetics, biochemistry and microbiology, and colleagues report their findings this week in Proceedings of the National Academy of Sciences (PNAS). Co-authors include researchers from Wright State University and the Laboratory for Health Protection Research, National Institute of Public Health and the Environment, the Netherlands.

Stambrook says the gene CHEK2 is part of a DNA damage response pathway that can have an impact on whether or not cancers develop. A CHEK2 variant, CHEK2*1100delC, is associated with increased risk of cancer.

"Women who carry this particular gene variant are predisposed to developing breast or ovarian cancer," says Stambrook, "while men have a higher risk of developing prostate cancer."

Stambrook's team has produced a mouse model in which the CHEK2 gene was replaced by the variant and found that the overwhelming majority of mice that developed cancer were femaleabout 80 percent, as opposed to slightly more than 15 percent for males. This contrasts sharply with the incidence of cancer in wild-type mice (those with the normal CHEK2 gene), in which male and female mice developed cancer to about the same extent but at a much lower frequency.

Stambrook says his team will be exploring possible reasons behind the difference, looking at hormonal involvement and possible interactions between the gene variant and estrogen receptors or estrogen itself.

By using a known carcinogen, dimethyl benzanthracene, the researchers also determined that mice that harbor the variant are more susceptible to an environmental challenge than those that don't. The compound was administered orally to female mice.

"When they delivered the compound, the lifespan of the mice was reduced significantlythey developed breast cancer as well as other types of cancers," Stambrook says. "In addition, the mice that harbored this variant were more susceptiblein other words, they developed tumors more quickly than wild-type mice."

Stambrook says that by learning more about the signaling pathway of the CHEK2 gene, researchers can explore ways to "rescue" it and identify potential therapeutic targets.

"It's an interesting gene," says Stambrook, "and there are a lot of interesting directions that this finding will take us."


'/>"/>

Contact: Keith Herrell
keith.herrell@uc.edu
513-558-4559
University of Cincinnati Academic Health Center
Source:Eurekalert

Related medicine news :

1. Head, Neck Cancer Treatment Often Not Completed
2. Researchers Propose Improved Cervical Cancer Screening
3. World Health Organization Launches New Attack on Lung Cancer
4. John Theurer Cancer Center and Leukemia & Lymphoma Society Highlight Upcoming Trends in Hematological Malignancies
5. News from Medialink and P&G: Procter & Gamble Partners with National Breast Cancer Foundation, Inc. to GIVE HOPE to Millions of Women Across the Country
6. Study Published in The Lancet Showed Significant Survival Benefit for Patients Facing Deadly Form of Lung Cancer
7. Surgeon Battling Own Cancer Developed New Treatment
8. New Chemo Regimen May Benefit Ovarian Cancer Patients
9. New Drug May Offer Hope to Some With Lung Cancer
10. Hormone Therapy May Make Lung Cancer More Likely
11. Mens Health Network, The Washington Redskins and GlaxoSmithKline Team Up for Septembers Prostate Cancer Awareness Month
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... ... “The Adventures of Joey, The Dog Who Barks at Puddles”: a boisterous story about ... as God intended. “The Adventures of Joey, The Dog Who Barks at Puddles” is ... for writing, especially about truth and human behavior. , Published by Christian Faith Publishing, ...
(Date:3/23/2017)... , ... March 23, 2017 , ... A recent report ... entry into teacher preparation programs. The NCTQ report suggests, based on a review of ... would significantly improve teacher quality in the U.S. It argues that this higher bar ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... to their communities, 16 more public health departments have been awarded national accreditation ... another 4.5 million people into the expanding network of communities across the nation ...
(Date:3/23/2017)... ... March 23, 2017 , ... PAINWeekEnd (PWE) Oklahoma City, on ... Avenue, will be an educational and exciting program providing busy clinicians and allied ... chronic pain. , Oklahoma is in a healthcare crisis. The state ranks 46th ...
(Date:3/23/2017)... ... 23, 2017 , ... The MBI “Hall of Fame” recognizes the contributions of those whose careers ... impact on the careers of all others involved. , On Monday, March 21st, ... MBI’s Hall of Fame. The induction took place during the World of Modular – ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... Wash. , March 23, 2017  Mirabilis ... of advanced medical technology for non-invasive surgery, announced ... Mirabilis System for treatment of uterine fibroids throughout ... it had received approval from the US Food ... of the Mirabilis System in the United States.  ...
(Date:3/23/2017)... Research and Markets has announced the addition of the ... 2025" report to their offering. ... The Global Cryostat Market is poised to ... to reach approximately $3.5 billion by 2025. This industry ... segments on global as well as regional levels presented in the ...
(Date:3/23/2017)... March 23, 2017  Transportation Insight, a multi-modal lead ... supply chain management firm with expertise serving clients in ... Rick Zaffarano was named a 2017 ... Chain by the only publication exclusively dedicated to covering ... chain. "Rick has brought to Transportation Insight ...
Breaking Medicine Technology: