Navigation Links
Cancer patients and doctors report drug side effects differently

In clinical trials for cancer, it is standard for clinicians rather than patients to report adverse symptom side effects from treatments, such as nausea and fatigue. At present, patient self-reporting, although important, is not a well studied source of this information. A new longitudinal study from researchers at Memorial Sloan-Kettering Cancer Center finds that while clinicians' and patients' reporting of treatment side effects are very different from each other, together they provide a more complete, clinically meaningful picture of the treatment experience.

The research was published online November 17 in the Journal of the National Cancer Institute. Ethan Basch, MD, a medical oncologist and member of the Health Outcomes Group at Memorial Sloan-Kettering, and colleagues, led an analysis of data gathered from more than 160 advanced lung cancer patients and their clinicians. All of the patients were treated at Memorial Sloan-Kettering.

The patients, both men and women with a median age of 63, were followed from 2005 to 2006 through an average of 12 office visits. All received chemotherapy during this time. Researchers tracked six common symptoms--fatigue, pain, nausea, vomiting, diarrhea, and constipation--and compared the side effects reported by the clinicians to those reported by the patients. The clinicians reported symptoms using the standard adverse event reporting tool for oncology trials, the National Cancer Institute's Common Terminology Criteria for Adverse Events (CTCAE.) Patients reported symptoms using a simplified version of the same reporting tool via a computer-based system.

Patients generally reported adverse symptoms earlier, more frequently, and with greater severity than their clinicians, and their responses appeared to better reflect real-time suffering. Patient-reported symptoms were more closely related to day-to-day health status, while clinicians' reports were more predictive of significant medical events. "The perspectives of both clinicians and patients provide a more complete picture of the negative impact of treatments compared with either perspective alone," said Dr. Basch. "Clinicians bring professional training and experience to their evaluations, whereas patients are in a better position to communicate their own subjective experiences," he adds.

The findings demonstrate the value of an approach that incorporates patient self-reporting of symptoms in cancer treatment trials. Such information has the potential to help both prospective prescribers and patients in understanding the anticipated side effects of treatment.

On the basis of this research Dr. Basch said, "We need to design models in which we can capitalize on what the patient is reporting in order to understand how toxic these drugs are. Our patients add tremendous value in their reporting; and by collecting this information we can actually enhance our understanding of toxicities in a way that will aid the FDA, aid clinicians, aid researchers, and aid patients themselves when they are trying to decide whether they want to start a treatment." He added that, "patient-reported adverse symptoms should be collected in clinical trials and reported in drug labels."


Contact: Jeanne DAgostino
Memorial Sloan-Kettering Cancer Center

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Survival differences by race most apparent in advanced stages of breast cancer
3. MRI finds breast cancer before it becomes dangerous
4. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
5. Pathway links inflammation, angiogenesis and breast cancer
6. Radiologists encouraged to look beyond cancer for clinically unseen diseases
7. Diet high in meat, fat and refined grains linked to risk for colon cancer recurrence, death
8. Immune deficiency linked to a type of eye cancer
9. Drop in breast cancer incidence linked to hormone use, not mammograms
10. Breast cancer prevention practices vary across Canada
11. First biomarker discovered that predicts prostate cancer outcome
Post Your Comments:
(Date:11/24/2015)... ... November 24, 2015 , ... ... States to support their local poison centers through donations on Tuesday, Dec. 1, ... calls it “a day that inspires people to collaborate in improving their local ...
(Date:11/24/2015)... R.I. (PRWEB) , ... November 24, 2015 , ... With ... Amica Insurance is sharing safety tips to help protect your family and vehicle. , ... crashes around the 2013 Thanksgiving holiday weekend. Amica is sharing the following safety tips ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... designated an Aetna Institute of Quality® Bariatric Surgery Facility for treating individuals living ... cost of health care services available to its members to help them make ...
(Date:11/24/2015)... ... November 24, 2015 , ... Sir Grout of Baltimore is ... certification. The award recognizes good companies for excellence in service and a commitment ... and hard surface restoration company earned this recognition after a thorough review by ...
(Date:11/24/2015)... York, N.Y. (PRWEB) , ... November 24, 2015 , ... ... Giving Tuesday, the global movement driven by social media and the generosity of people ... Speaks, then encourage their social media networks to give – and share the personal ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)...   Renowned ... deliver s advice and insights on supplements and ... than 50% of Dubai residents ... the DHA   femMED launches comprehensive solutions for women ... Dubai residents are not consuming enough to keep themselves healthy. ...
(Date:11/24/2015)... , Nov. 24, 2015 Abaxis, Inc. (NasdaqGS: ... instruments and consumables for the medical, research, and veterinary ... Chief Financial Officer, will present at the 27 th ... 1, 2015 at 11:30 a.m. ET. The conference will ... New York City . ...
(Date:11/24/2015)... Edelris announce today that they have ... Poxel, CNRS, UCBL and ENS-Lyon on a new treatment to ... Hepatitis B virus (HBV) infection is a major public ... worldwide, 20 to 40% of them being at risk of ... existence of an effective preventive vaccine, the HBV infection is ...
Breaking Medicine Technology: