Navigation Links
Cancer-obesity link discovery by MSU researchers could aid prevention efforts
Date:4/30/2009

EAST LANSING, Mich. A new link between body fat and cancer identified by a Michigan State University researcher underscores obesity's health risk and could lead to new cancer treatment and prevention strategies.

Jenifer Fenton, an MSU food science and human nutrition researcher with the Michigan Agricultural Experiment Station, identified the connection between obesity and colon cancer, the third-leading killer of Americans, in part by examining tissue hormones.

Working with MSU/MAES physiologist Julia Busik and biologist Fay Hansen-Smith of Oakland University in Rochester, Mich., Fenton examined a key hormone found in fat tissue and thought to promote cancer. Her conclusions are published in a study today in the journal Carcinogenesis.

Leptin a fat cell-derived hormone regulating body energy is higher in obese individuals. Fenton's study is the first to demonstrate that, at higher levels, leptin induces precancerous colon cells to produce more of a growth factor that can increase blood supply to early cancer cells promoting tumor growth and cancer progression.

"Adipose tissue, or fat, is recognized as a significant risk factor for diabetes and heart disease, but the role of adipose tissue in cancer risk is less understood," Fenton said. "Abdominal fat in particular seems to be associated with the greatest risk for cancer. As your waist-to-hip ratio increases, so does your risk for cancer, especially breast, colon and endometrial cancers."

Some 149,000 Americans will be diagnosed with colon cancer and 50,000 will die from it this year, according to the American Cancer Society. More than a million have been diagnosed with colon or rectal cancer in the U.S. as of 2006, the National Cancer Institute reported.

Fenton and her team focused on colon cancer because, unlike breast or prostate cancer, colon cancer affects both genders equally, allowing them broader reach and a larger impact on cancer prevention.

"Trying to address the problem when someone already has a late-stage tumor is not primary prevention," Fenton said. "Our goal is to understand the active signals and mechanisms involved so we can create opportunities to prevent or interrupt cancer progression early in the process.

"The impact of obesity and cancer are a priority for the health of the nation," Fenton added. "Although weight loss is the ideal prevention strategy for reducing obesity as a risk factor for colon cancer, 95 percent of all people who lose weight will gain it back and often more within a year, so behavior modification as a prevention strategy is difficult and challenging. For this reason, continuing research also will include the identification of dietary compounds that may prevent or reduce colon cancer risk associated with obesity in the absence of weight loss."


'/>"/>

Contact: Mark Fellows
mark.fellows@ur.msu.edu
517-884-0166
Michigan State University
Source:Eurekalert  

Related medicine news :

1. WA discovery a key to blood cell development
2. Stanford researchers discovery of ion channel turns ear on its head
3. Chicagos Top Minds Join National Business and Health Leaders in Addressing Medical Innovation, Highlighting Policies Needed to Maintain U.S. Competitiveness in Medical Science and Discovery
4. Discovery of variations in resistance to sulfadoxine across Africa
5. Gene fusion discovery may lead to improved prostate cancer test
6. Effective Weight Management with Gene-Eden, a New Dietary Supplement Based on Dr. Hanan Polanskys Discovery
7. Discovery may result in new test to determine predisposition to cancer
8. How to Keep the Weight Off? By Taking Gene-Eden, a New Dietary Supplement Based on Dr. Hanan Polanskys Discovery of the Cause of Many Diseases
9. Major Asthma Research Discovery Could Lead to New Drugs
10. Seahorse XF96 Extracellular Flux Analyzer Wins Best New Product Award for DRUG DISCOVERY at 2009 Molecular Medicine Conference
11. Obio Pharmaceutical Announced New Antiviral Drug Discovery to Combat Influenza Virus
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cancer-obesity link discovery by MSU researchers could aid prevention efforts
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs surgery services, can now ... and to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings ... The selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the ...
(Date:6/25/2016)... Oklahoma (PRWEB) , ... June 25, 2016 , ... ... both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures ... Oklahoma City area —Johnson is one of the first doctors to perform the ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle ... chronic pain and the benefits of holistic treatments, Serenity Recovery Center of ... Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, ... and the Road To Recovery® program to drive cancer patients to and from their ... to ensure the highest quality of life and ongoing independence. Getting to and ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... client, The Grove Investment Group (TGIG), has initiated cultivation and processing operations at ... Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a complete ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical Systems ... "Company"), which develops, markets and sells medical devices and ... , signed a strategic cooperation agreement with Hongyuan Supply ... Supply Chain") on June 20, 2016, to develop Dehaier,s ... strategic cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s ...
(Date:6/24/2016)... Mass. , June 24, 2016   Pulmatrix, ... pharmaceutical company developing innovative inhaled drugs, announced today that ... Russell Investments reconstituted its comprehensive set of ... "This is an important milestone for Pulmatrix," ... will increase shareholder awareness of our progress in developing ...
(Date:6/23/2016)... Research and Markets has announced the addition of the ... report to their offering. ... failure, it replaces the function of kidneys by removing the ... the treatment helps to keep the patient body,s electrolytes such ... Increasing number of ESRD patients & substantial healthcare expenditure on ...
Breaking Medicine Technology: