Navigation Links
Cancer-obesity link discovery by MSU researchers could aid prevention efforts
Date:4/30/2009

EAST LANSING, Mich. A new link between body fat and cancer identified by a Michigan State University researcher underscores obesity's health risk and could lead to new cancer treatment and prevention strategies.

Jenifer Fenton, an MSU food science and human nutrition researcher with the Michigan Agricultural Experiment Station, identified the connection between obesity and colon cancer, the third-leading killer of Americans, in part by examining tissue hormones.

Working with MSU/MAES physiologist Julia Busik and biologist Fay Hansen-Smith of Oakland University in Rochester, Mich., Fenton examined a key hormone found in fat tissue and thought to promote cancer. Her conclusions are published in a study today in the journal Carcinogenesis.

Leptin a fat cell-derived hormone regulating body energy is higher in obese individuals. Fenton's study is the first to demonstrate that, at higher levels, leptin induces precancerous colon cells to produce more of a growth factor that can increase blood supply to early cancer cells promoting tumor growth and cancer progression.

"Adipose tissue, or fat, is recognized as a significant risk factor for diabetes and heart disease, but the role of adipose tissue in cancer risk is less understood," Fenton said. "Abdominal fat in particular seems to be associated with the greatest risk for cancer. As your waist-to-hip ratio increases, so does your risk for cancer, especially breast, colon and endometrial cancers."

Some 149,000 Americans will be diagnosed with colon cancer and 50,000 will die from it this year, according to the American Cancer Society. More than a million have been diagnosed with colon or rectal cancer in the U.S. as of 2006, the National Cancer Institute reported.

Fenton and her team focused on colon cancer because, unlike breast or prostate cancer, colon cancer affects both genders equally, allowing them broader reach and a larger impact on cancer prevention.

"Trying to address the problem when someone already has a late-stage tumor is not primary prevention," Fenton said. "Our goal is to understand the active signals and mechanisms involved so we can create opportunities to prevent or interrupt cancer progression early in the process.

"The impact of obesity and cancer are a priority for the health of the nation," Fenton added. "Although weight loss is the ideal prevention strategy for reducing obesity as a risk factor for colon cancer, 95 percent of all people who lose weight will gain it back and often more within a year, so behavior modification as a prevention strategy is difficult and challenging. For this reason, continuing research also will include the identification of dietary compounds that may prevent or reduce colon cancer risk associated with obesity in the absence of weight loss."


'/>"/>

Contact: Mark Fellows
mark.fellows@ur.msu.edu
517-884-0166
Michigan State University
Source:Eurekalert  

Related medicine news :

1. WA discovery a key to blood cell development
2. Stanford researchers discovery of ion channel turns ear on its head
3. Chicagos Top Minds Join National Business and Health Leaders in Addressing Medical Innovation, Highlighting Policies Needed to Maintain U.S. Competitiveness in Medical Science and Discovery
4. Discovery of variations in resistance to sulfadoxine across Africa
5. Gene fusion discovery may lead to improved prostate cancer test
6. Effective Weight Management with Gene-Eden, a New Dietary Supplement Based on Dr. Hanan Polanskys Discovery
7. Discovery may result in new test to determine predisposition to cancer
8. How to Keep the Weight Off? By Taking Gene-Eden, a New Dietary Supplement Based on Dr. Hanan Polanskys Discovery of the Cause of Many Diseases
9. Major Asthma Research Discovery Could Lead to New Drugs
10. Seahorse XF96 Extracellular Flux Analyzer Wins Best New Product Award for DRUG DISCOVERY at 2009 Molecular Medicine Conference
11. Obio Pharmaceutical Announced New Antiviral Drug Discovery to Combat Influenza Virus
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cancer-obesity link discovery by MSU researchers could aid prevention efforts
(Date:2/12/2016)... ... ... The law firm of Morrow, Morrow, Ryan & Bassett is offering scholarships to ... to encourage applicants to pursue a degree in their field of study and upon ... “We have available jobs in St. Landry and Evangeline Parishes that can be filled ...
(Date:2/12/2016)... Falls Church, VA (PRWEB) , ... February 12, ... ... in Store?, Feb. 29, 2016 — 1:30 p.m. – 3:00 p.m. EST, ... burner issue in the life cycle of pharmaceutical products, garnering increased attention from ...
(Date:2/12/2016)... ... February 12, 2016 , ... T.E.N., a ... closed for the ISE Southeast Awards 2016. Finalists and winners of the ISE® ... Southeast Executive Forum and Awards Gala on March 15, 2016 at the Westin ...
(Date:2/12/2016)... , ... February 12, 2016 , ... Fisher House Foundation ... Mayor John J. Lee, Nevada Military Support Alliance president Scott Bensing, and Peggy Kearns ... the VA Southern Nevada Healthcare System. This will be the first Fisher House ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... Erlanger Agency ... the greater Columbus, OH area. The latest campaign focuses on the fight against breast ... Donations are now being accepted here . , Carmen is a loving single ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)...  Memorial Hermann Health System has teamed up with ... bring a one-of-a-kind experience to pediatric patients at ... as 360-degree video and Google Cardboard, Howard was able ... giving the patients and their families an unexpected, and ... on video . Memorial Hermann IRONMAN ...
(Date:2/12/2016)... Feb. 12, 2016  Aralez Pharmaceuticals Inc. (Nasdaq: ... the Company will ring the Nasdaq Closing Bell at ... York at 4:00 p.m. ET on Tuesday, ... Adrian Adams , will perform the ... to 4:00 p.m. ET.  A live webcast will be ...
(Date:2/12/2016)... 2016 --> ... Inflammation Global Clinical Trials Review, H2, 2015 provides ... clinical trials landscape along with top level data ... (G7 & E7), Trial Status, Trial Phase, Sponsor ... companies involved and enlists all trials (Trial title, ...
Breaking Medicine Technology: