Navigation Links
Cancer may require simpler genetic mutations than previously thought
Date:5/25/2012

Chromosomal deletions in DNA often involve just one of two gene copies inherited from either parent. But scientists haven't known how a deletion in one gene from one parent, called a "hemizygous" deletion, can contribute to cancer.

A research team led by Stephen Elledge, a professor in the Department of Genetics at Harvard Medical School, and his post-doctoral fellow Nicole Solimini, has now provided an answer. The most common hemizygous deletions in cancer, their research shows, involve a variety of tumor suppressing genes called STOP genes (suppressors of tumorigenesis and proliferation) that scatter randomly throughout the genome, but that sometimes cluster in the same place on a chromosome. And these clusters, said Elledge, who is also a professor of medicine at Brigham and Women's Hospital, tend to be deleted as a group. "Eliminating the cluster gives a bigger bang for the deletion buck," he said.

This finding is especially interesting in light of the two-hit model of cancer formation, which holds that both copies of a recessive gene need to be inactivated to trigger a biological effect. Thus the loss of a single tumor suppressor copy should have little or no influence on tumor cell proliferation because the remaining copy located on the other chromosome is there to pick up the slack.

Elledge's research points to a different hypothesis, namely that STOP genes in a hemizygous deletion aren't recessive but are instead haploinsufficient, meaning that they depend on two copies to function normally. "If a tumor suppressor is haploinsufficient, then a single gene copy lacks the potency needed to fully restrain tumorigenesis," Elledge explained, who is also a Howard Hughes Medical Institute Investigator. "So by removing clusters of haploinsufficient genes all at once, the cancer cell immediately propels its growth forward without having to wait for the other copies to also be lost."

Angelika Amon, a professor of biology at
'/>"/>

Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Enhancing arrest of cell growth to treat cancer in mice
2. Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer
3. The National Coalition for Cancer Survivorship Joins the Commission on Cancer
4. Low forms of cyclin E reduce breast cancer drugs effectiveness
5. Racial disparities persist in the diagnosis of advanced breast cancer and colon cancer in the U.S.
6. Soft drinks may increase risk of pancreatic cancer
7. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
8. Genes Play Role in Prognosis With Non-Small Cell Lung Cancers
9. Single gene mutation induces endometrial cancer
10. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
11. Molecular pathways linked to sex, age affect outcomes in lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... 22, 2014 (HealthDay News) -- New research raises doubts ... cancer. Smokers with cancer who used e-cigarettes along ... those who didn,t use the devices, a Memorial Sloan ... likely -- or less likely -- to have quit ... The study, published online Sept. 22 in Cancer ...
(Date:9/22/2014)... Montreal, Quebec (PRWEB) September 22, 2014 ... understanding of chronic myelogenous leukemia, a form of blood ... CML is caused by a mutation affecting chromosomes 22 ... become a powerful symbol as the worldwide community unites ... it affects. , CML is at the forefront of ...
(Date:9/22/2014)... York, NY (PRWEB) September 22, 2014 ... City, has just posted a new article to its ... feel more than just a tad dismayed. Titled “Coffee ... article, http://www.lifeant.com/coffee-drinkers-beware-paying-life-insurance/ states on average, coffee fans ... premiums than those who do not enjoy the tasty ...
(Date:9/22/2014)... (PRWEB) September 22, 2014 As football season ... starting to put together their fantasy football leagues to prep ... also prepping as they work on new ways to bring ... Mica Lounge, located in the Sheraton Silver Spring Hotel, is ... own “Sheraton League” where locals and hotel guests can sign ...
(Date:9/22/2014)... New York, NY (PRWEB) September 22, 2014 ... - Dr. Beth Schrope , NewYork-Presbyterian/Columbia University ... or auto islet surgery, to prevent diabetes in ... is the first center in the New York ... Every year, roughly 87,000 people in the United ...
Breaking Medicine News(10 mins):Health News:E-Cigarettes Don't Help Cancer Patients Quit Smoking: Study 2Health News:Marking World CML Day on September 22nd 2Health News:Marking World CML Day on September 22nd 3Health News:Coffee Drinkers Are Charged More For Life Insurance, Reports LifeAnt.com 2Health News:Sheraton Silver Spring Hotel Keeps Football Fans Engaged Online and in their Lounge 2Health News:Sheraton Silver Spring Hotel Keeps Football Fans Engaged Online and in their Lounge 3Health News:Sheraton Silver Spring Hotel Keeps Football Fans Engaged Online and in their Lounge 4Health News:New Treatment May Prevent Diabetes After Pancreatitis Surgery 2Health News:New Treatment May Prevent Diabetes After Pancreatitis Surgery 3
... A new study investigating the potential beneficial effects ... of anti-TNFa treatment in aging," appears in the ... ,This study shows hope for significantly ... been linked to blood vessel dysfunction and cell ...
... to your high blood pressure might just be your ... evidence suggests that inflammation, a part of the immune ... diabetes, may also help translate stress into high blood ... is an inflammatory condition,” says Dr. Haidong Zhu, molecular ...
... reduction pill, which works better and faster than existing drugs// ... and cancer. ,Existing anti-obesity pills generally cut weight ... ,But men and women taking Excalia, the new ... lost 12 percent of their body weight, according to the ...
... undergo a double hand transplant was ecstatic as she got ... "I'm doing very well, I'm very happy. I'm taking steps ... life. When I saw the hands after the operation, they ... her arms following an explosion in a laboratory in 1978, ...
... better safety for patients in ICU by adhering to ... threatening// catheter-related infections. ICUs can become thoroughly aseptic by ... syringes and catheters. A detailed report was made by ... of the report are published in New England Journal ...
... more people succumbed to Rift Valley Fever in Garissa district, ... has been made by the North Eastern Provincial// Medical Officer ... cautioned the public to seek medical attention as quickly as ... the disease is due to lack of awareness. But local ...
Cached Medicine News:Health News:Effects Of Age-related Vascular Diseases Can Be Reduced By Inactivating TNFa 2Health News:Inflammatory Genes Linked to Salt-Sensitive Hypertension 2Health News:Inflammatory Genes Linked to Salt-Sensitive Hypertension 3Health News:Simple Steps to Safe Guard Patients from Bloodstream Infections in ICU 2
(Date:9/22/2014)... 2014 /CNW/ - T-Bird Pharma Inc. (TSXV:TPI) ("T-Bird" or ... quality medical marijuana products, is pleased to announce that ... signed a definitive lease agreement for a second facility ... facility has 28,966 square feet of floor space with ... mezzanine space for a total of approximately 43,500 square ...
(Date:9/22/2014)... Sept. 22, 2014 /PRNewswire/-- CANTEL MEDICAL CORP. (NYSE: CMN ... fiscal 2014 ended July 31, 2014 on Monday, September 29 ... discuss the results at 11:00 AM ET. Participating in the ... Andrew A. Krakauer , President and CEO; Jorgen B. ... Sheldon , Senior Vice President, CFO and Treasurer; and ...
(Date:9/22/2014)... , Sept. 22, 2014  Olympus, a global ... for medical and surgical procedures, among other core ... with Munich -based Brainlab to ... Navigation. This agreement applies to the US ... U.S. sales and all distribution outside the U.S. ...
Breaking Medicine Technology:T-Bird Pharma Inc. to Increase Growing Capacity with Expansion into a 43,500 square feet Second Facility 2T-Bird Pharma Inc. to Increase Growing Capacity with Expansion into a 43,500 square feet Second Facility 3Cantel Medical Corp. To Hold Conference Call To Discuss Results For Its Fourth Quarter And Fiscal 2014 Ended July 31, 2014 2Olympus Partners with Brainlab as Exclusive Distributor for ENT Products in U.S. Market 2Olympus Partners with Brainlab as Exclusive Distributor for ENT Products in U.S. Market 3Olympus Partners with Brainlab as Exclusive Distributor for ENT Products in U.S. Market 4
Recommended to insert plug portion of all monocanalicular intubation systems into punctum....
Skin Tone External Eyelid Weights...
To prevent retraction of the conjunctival cul-de-sacs without touching the cornea....
Bioceramic orbital implants insert easily into orbital socket and will not cling to surrounding tissue. Improved interconnectivity between pores enhances vascularization. Implants may be easily drill...
Medicine Products: