Navigation Links
Cancer-linked FAM190A gene found to regulate cell division
Date:7/3/2013

Johns Hopkins cancer scientists have discovered that a little-described gene known as FAM190A plays a subtle but critical role in regulating the normal cell division process known as mitosis, and the scientists' research suggests that mutations in the gene may contribute to commonly found chromosomal instability in cancer.

In laboratory studies of cells, investigators found that knocking down expression of FAM190A disrupts mitosis. In three pancreatic cancer-cell lines and a standard human-cell line engineered to be deficient in FAM190A, researchers observed that cells often had difficulty separating at the end of mitosis, creating cells with two or more nuclei. The American Journal of Pathology published a description of the work online May 17, which comes nearly a century after German scientist Theodor Boveri linked abnormal mitosis to cancer. Until now, there had been no common gene alteration identified as the culprit for cancer-linked mitosis.

"These cells try to divide, and it looks like they succeed, except they wind up with a strand that connects them," explains Scott Kern, M.D., professor of oncology and pathology at Johns Hopkins University School of Medicine and its Kimmel Cancer Center. "The next time they try to divide, all the nuclei come together, and they try to make four cells instead of two. Subsequently, they try to make eight cells, and so on." Movies of the process taken by Kern's laboratory are available on the journal Web site.

Kern's group previously reported that deletions in the FAM190A gene could be found in nearly 40 percent of human cancers. That report, published in 2011 in the journal Oncotarget, and the current one are believed to be the only published papers focused solely on FAM190A, which is frequently altered in human cancers but whose function has been unknown. Alterations in FAM190A messages may be the third most common in human cancers after those for the more well-known genes p53 a
'/>"/>

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2914
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. More Fake Avastin Found in U.S., FDA Says
2. Kessler Foundation names Dr. John Whyte recipient of Foundations 2nd Annual DeLisa Award
3. History of abandoned urban sites found stored in soil
4. Wilderness Medicine founder offers health tips for summer season
5. Concerns about MRSA for expectant mothers may be unfounded
6. Kessler Foundation scientist awarded $554,000 for multiple sclerosis employment research
7. Clues to Slacker Behavior Found in Brain, Study Says
8. Kessler Foundation researchers present at first International Congress on Cognition in MS
9. Biomedical researchers receive Hartwell Foundation awards
10. Fewer prostate cancer surgery complications found in teaching hospitals with fellowship programs
11. Breast cancer effectively treated with chemical found in celery, parsley by MU researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... , ... August 03, 2015 , ... ... ALS and amputation , AUGUST 3, 2015 – Since winning a South by ... 2015, Not Impossible – an organization whose mission is to develop technology for ...
(Date:8/3/2015)... ... August 03, 2015 , ... Sensato ... program “Designing Secure Healthcare Systems” This three-day, highly interactive and immersive workshop, ... organizations with access to the tactics, techniques and practices required to design and ...
(Date:8/3/2015)... ... August 03, 2015 , ... From 2006-2017 the number of ... to market research compiled for the National Association of Dental Laboratories ( NADL ... Bureau of Labor Statistics. As the number of dental laboratories decreases, dentists will ...
(Date:8/3/2015)... ... August 03, 2015 , ... ... with accountability for overall performance of the company’s Medicare and Federal Employee Programs ... Cambia’s strategy to deliver better health for members. In this role, Scott is ...
(Date:8/3/2015)... ... , ... Recent reports by the American Medical Association show that over 80% ... Often time, low back and sciatic pain can happen as a result of vertebral ... powerful pain medication or spinal surgery. Dynamic Health Care in Louisville, KY , ...
Breaking Medicine News(10 mins):Health News:Not Impossible Earns Top Awards for Technologies Benefiting Humanity 2Health News:Not Impossible Earns Top Awards for Technologies Benefiting Humanity 3Health News:Not Impossible Earns Top Awards for Technologies Benefiting Humanity 4Health News:Sensato and Divurgent are pleased to announce the development of it’s new program “Designing Secure Healthcare Systems” 2Health News:Sensato and Divurgent are pleased to announce the development of it’s new program “Designing Secure Healthcare Systems” 3Health News:Sensato and Divurgent are pleased to announce the development of it’s new program “Designing Secure Healthcare Systems” 4Health News:Dental Association Announces Impending Reduction of Dental Laboratories Could Impact Dentists 2Health News:Dental Association Announces Impending Reduction of Dental Laboratories Could Impact Dentists 3Health News:Cambia Health Solutions Names Scott Powers President of Government Programs 2Health News:Dynamic Health Care in Louisville, KY, Offers a New and Cutting-Edge Therapy for Low Back & Leg Pain Sufferers 2
... April 6 As consumers continue to adopt healthier ... guests by adding new menu items to their Guiltless ... the first casual dining restaurant concepts to create a ... healthier items in 1993. Along with the addition of ...
... ejaculation who used a topical spray five minutes before intercourse ... normal, according to a study in the April issue of ... diagnosed lifelong premature ejaculation (PE) from 31 centres in the ... groups. Two hundred used the PSD502 spray, which contains 7.5mg ...
... how Proactive Pharmacy Care approach leverages technology and face-to-face ... to medicationsWOONSOCKET, R.I., April 6 ... the role health IT is playing in optimizing the ... Conference & Exhibition, in Chicago, IL. At the conference, ...
... , , ISELIN, N.J., April ... that it has provided a $29,500,000 credit facility to ... Group, LLC ("AFG") to fund hospital acquisitions in California. ... revolving line of credit and term loan.(Logo: ...
... Communities across the Country Join the Observance in Support ... 6 The American Public Health Association (APHA) today ... Building the Foundation for a Healthy America . ... raise awareness of public health,s critical role in improving ...
... Information Workflow Drives Carefx,s Agenda at HIMSS Conference, ... 6 Carefx Corporation , ... existing systems and offers clinicians single, clinically relevant ... at this year,s Healthcare Information and Management Systems ...
Cached Medicine News:Health News:Chili's Celebrates Women with Curves 2Health News:Premature ejaculation spray enables men to last 6 times longer after penetration 2Health News:Premature ejaculation spray enables men to last 6 times longer after penetration 3Health News:CVS Caremark Discusses Role of Health IT to Optimize Pharmacy Health Care 2Health News:CVS Caremark Discusses Role of Health IT to Optimize Pharmacy Health Care 3Health News:Siemens Financial Services, Inc. Provides $29.5 Million Credit Package to Avanti Health System 2Health News:Siemens Financial Services, Inc. Provides $29.5 Million Credit Package to Avanti Health System 3Health News:Siemens Financial Services, Inc. Provides $29.5 Million Credit Package to Avanti Health System 4Health News:National Public Health Week Begins Today With Launch of Viral Video Campaign 2Health News:Carefx Showcases Expanded Fusionfx Solution Suite and Profiles Changing Roles of CIOs at Executive Roundtable 2Health News:Carefx Showcases Expanded Fusionfx Solution Suite and Profiles Changing Roles of CIOs at Executive Roundtable 3Health News:Carefx Showcases Expanded Fusionfx Solution Suite and Profiles Changing Roles of CIOs at Executive Roundtable 4
(Date:8/3/2015)... , August 3, 2015 ... FN Media Group LLC, PIV757417 The following release: ... Developing Orphan Drug Products & Treatments for Critical-Care ... HOLD. Distribution time: 3 Aug 2015 12:30 GMT ... biotech companies, military surgical research and top-tier universities ...
(Date:8/3/2015)... N.J. , Aug. 3, 2015  Celsion ... the Company will host a conference call to ... provide an update on its development programs for ... and two newly acquired technology platforms, TheraPlas™ and ... a.m. EDT on Monday, August 10, 2015. To ...
(Date:8/3/2015)... , Aug. 3, 2015  EnteroMedics Inc. (NASDAQ: ETRM ... to treat obesity, metabolic diseases and other gastrointestinal disorders, ... been appointed to the Board of Directors, effective July ... II Director until the 2018 annual meeting or until ... McDougal has served in an executive capacity in the ...
Breaking Medicine Technology:/OFF HOLD OFF HOLD OFF HOLD -- FN Media Group LLC/ 2/OFF HOLD OFF HOLD OFF HOLD -- FN Media Group LLC/ 3/OFF HOLD OFF HOLD OFF HOLD -- FN Media Group LLC/ 4/OFF HOLD OFF HOLD OFF HOLD -- FN Media Group LLC/ 5/OFF HOLD OFF HOLD OFF HOLD -- FN Media Group LLC/ 6Celsion Corporation to Hold Second Quarter 2015 Financial Results Conference Call on Monday, August 10, 2015 2EnteroMedics Announces Appointment of Lori C. McDougal to the Board of Directors 2EnteroMedics Announces Appointment of Lori C. McDougal to the Board of Directors 3
... , NEW YORK , Jan. ... development of transformative treatments for Parkinson,s disease, The Michael J. ... $2.1 million in awards to six biotech and pharmaceutical ... The funding will drive pre-clinical projects pushing forward investigations of ...
... , ATLANTA , ... the market leader in automated revenue integrity solutions that improve ... its first customer. , Supplies ChargeLink™ is ... reimbursement for chargeable supplies. It does this by establishing and ...
Cached Medicine Technology:Michael J. Fox Foundation Awards $2.1 Million to Drive Six Industry Teams' Pre-Clinical Development of Neuroprotective Parkinson's Therapies 2Michael J. Fox Foundation Awards $2.1 Million to Drive Six Industry Teams' Pre-Clinical Development of Neuroprotective Parkinson's Therapies 3Craneware's New Product Reduces Supply Chain Revenue Leakage 2Craneware's New Product Reduces Supply Chain Revenue Leakage 3Craneware's New Product Reduces Supply Chain Revenue Leakage 4
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: