Navigation Links
Cancer-linked FAM190A gene found to regulate cell division
Date:7/3/2013

Johns Hopkins cancer scientists have discovered that a little-described gene known as FAM190A plays a subtle but critical role in regulating the normal cell division process known as mitosis, and the scientists' research suggests that mutations in the gene may contribute to commonly found chromosomal instability in cancer.

In laboratory studies of cells, investigators found that knocking down expression of FAM190A disrupts mitosis. In three pancreatic cancer-cell lines and a standard human-cell line engineered to be deficient in FAM190A, researchers observed that cells often had difficulty separating at the end of mitosis, creating cells with two or more nuclei. The American Journal of Pathology published a description of the work online May 17, which comes nearly a century after German scientist Theodor Boveri linked abnormal mitosis to cancer. Until now, there had been no common gene alteration identified as the culprit for cancer-linked mitosis.

"These cells try to divide, and it looks like they succeed, except they wind up with a strand that connects them," explains Scott Kern, M.D., professor of oncology and pathology at Johns Hopkins University School of Medicine and its Kimmel Cancer Center. "The next time they try to divide, all the nuclei come together, and they try to make four cells instead of two. Subsequently, they try to make eight cells, and so on." Movies of the process taken by Kern's laboratory are available on the journal Web site.

Kern's group previously reported that deletions in the FAM190A gene could be found in nearly 40 percent of human cancers. That report, published in 2011 in the journal Oncotarget, and the current one are believed to be the only published papers focused solely on FAM190A, which is frequently altered in human cancers but whose function has been unknown. Alterations in FAM190A messages may be the third most common in human cancers after those for the more well-known genes p53 a
'/>"/>

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2914
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. More Fake Avastin Found in U.S., FDA Says
2. Kessler Foundation names Dr. John Whyte recipient of Foundations 2nd Annual DeLisa Award
3. History of abandoned urban sites found stored in soil
4. Wilderness Medicine founder offers health tips for summer season
5. Concerns about MRSA for expectant mothers may be unfounded
6. Kessler Foundation scientist awarded $554,000 for multiple sclerosis employment research
7. Clues to Slacker Behavior Found in Brain, Study Says
8. Kessler Foundation researchers present at first International Congress on Cognition in MS
9. Biomedical researchers receive Hartwell Foundation awards
10. Fewer prostate cancer surgery complications found in teaching hospitals with fellowship programs
11. Breast cancer effectively treated with chemical found in celery, parsley by MU researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... DC (PRWEB) August 01, 2014 ... Thompson (D-CA), Gregg Harper (R-MS), and Peter Welch ... 5380, the Medicare Telehealth Parity Act of 2014, ... fully support this effort to improve healthcare access ... chief executive officer of ATA. "These cost-saving provisions ...
(Date:8/1/2014)... 2014 Market Publishers Ltd announces ... been added to its catalogue. , ... (APIs), Contract Research and Manufacturing Services (CRAMS), Biosimilars, ... drivers include, among others, increasing ageing population, rising ... 2015, the pharma market in India is anticipated ...
(Date:8/1/2014)... August 01, 2014 On Monday, June ... NextGen User Symposium in San Francisco, CA. Now in ... the JW Marriott Union Square hotel. , “We are ... up to speed with ACA compliance issues,” Quirk Healthcare ... The symposium provides attendees guidance with NextGen implementation and ...
(Date:8/1/2014)... Patients with the progressive, deadly respiratory ailment known as ... to battle the disease, the U.S. Food and Drug ... new treatment, an inhaled spray called Striverdi Respimat (olodaterol) ... which is often linked to smoking, involves multiple lung ... Patients with COPD may experience a number of symptoms, ...
(Date:8/1/2014)... parents worry about their children choking on small objects or ... Such was the case for 15-month-old Landon Jones who started ... "At the time, Landon had a cold so it ... illness or choking," recalled his mother, Ula Jones. But, ... his windpipe and had to be removed via surgery. Landon ...
Breaking Medicine News(10 mins):Health News:ATA Applauds Bill on Medicare Telemedicine Improvements 2Health News:In-demand Markets Research Reports by Kelly Scientific Publications Now Available at MarketPublishers.com 2Health News:In-demand Markets Research Reports by Kelly Scientific Publications Now Available at MarketPublishers.com 3Health News:Quirk Healthcare Foundation Hosts Fifth Annual California NextGen User Symposium and Launches First Annual Florida NextGen User Symposium 2Health News:FDA Approves New Treatment for People With COPD 2Health News:Food Is a Common Choking Hazard for Kids, Doctor Says 2
... the National Academy of Sciences (IOM) in the US released ... calcium across all ages. The report is based on available ... role of these nutrients on bone health. Vitamin D deficiency ... been linked to the pathogenesis of osteoporosis and hip fractures ...
... (HealthDay News) -- A U.S. Food and Drug Administration advisory ... drugs for the prevention of prostate cancer, the third highest ... GlaxoSmithKline and Merck, respectively, are already approved to treat enlarged ... also lower the risk of prostate cancer by more than ...
... effect on our understanding of genetic biology and could usher ... review individual genome sequences to fully personalise medical treatment. ... for its $10m prize for the first privately funded company ... less than $10,000 per genome, the science writer Philip Ball ...
... Dec. 1 (HealthDay News) -- A test that measures the ... at an early stage and help doctors evaluate the effectiveness ... as early as possible -- before it destroys the optic ... the researchers, from the Bascom Palmer Eye Institute at the ...
... Reporter , TUESDAY, Nov. 30 (HealthDay News) -- Autistic children ... structure called the mitochondria, which is responsible for producing the ... defects may help to explain the onset or the severity ... the Dec. 1 issue of the Journal of the ...
... Academy of Otolaryngology Head and Neck Surgery (AAO-HNS), ... surgeons, has partnered with SAGE to publish its official ... in January 2011. A leading journal in the ... recent developments in treatment of the ear, nose, throat, ...
Cached Medicine News:Health News:IOF statement on new IOM dietary reference intakes for calcium and vitamin D 2Health News:FDA Panel to Vote on Drugs Said to Prevent Prostate Cancer 2Health News:Physicists use graphene to decode DNA 2Health News:Cell Dysfunction May Play Part in Autism 2Health News:Cell Dysfunction May Play Part in Autism 3Health News:AAO-HNSF partners with SAGE to publish Otolaryngology-Head and Neck Surgery 2
(Date:8/1/2014)... 2014  VanDeMark Chemical Inc., Lockport, ... phosgene and phosgene derivatives in North ... acquired Framochem Kft, a leading European-based manufacturer of ... . The purchase unites two companies ... the world,s largest, independent manufacturers of products based ...
(Date:8/1/2014)... PALO ALTO, Calif. , Aug. 1, ... (CFRI) today announced a partnership to expand awareness of ... through the CFChef Shares program. CFChef Shares will run ... of AbbVie,s CFChef program – an online resource for ... maintain a healthy diet by submitting recipes to the ...
(Date:8/1/2014)... India , Aug. 1, 2014  Neuland ... providing active pharmaceutical ingredients (APIs), complex ... customers located in 85 countries, today announced financial ... (FY) 2015, ended June 30, 2014. ... by work flow re-prioritization to accommodate certain customer ...
Breaking Medicine Technology:VanDeMark Chemical Inc. Acquires Framochem 2VanDeMark Chemical Inc. Acquires Framochem 3VanDeMark Chemical Inc. Acquires Framochem 4AbbVie and Cystic Fibrosis Research, Inc. (CFRI) Team Up to Raise Awareness of the Nutritional Needs of CF Patients through the CFChef Shares Program 2AbbVie and Cystic Fibrosis Research, Inc. (CFRI) Team Up to Raise Awareness of the Nutritional Needs of CF Patients through the CFChef Shares Program 3Neuland Labs Reports First Quarter Fiscal Year 2015 Financial Results 2Neuland Labs Reports First Quarter Fiscal Year 2015 Financial Results 3
... This remarkable anti-reflux valve ... plastic housing which prevents the ... closed when in sitting or ... virtually self-cleaning and interference free ...
... valve is enclosed in a ... the valve from being accidentally ... or reclining positions. The valve ... free ensuring uninterrupted flow and ...
... The VerifyNow (Ultegra) System is ... which measures platelet induced aggregation as ... system consists of an instrument, a ... assay device contains reagents based on ...
The Multiple Perfusion set provides simultaneous perfusion of the aortic root and up to three or more vein grafts. The set features an inlet port with female luer and clamp attached to an adapter whi...
Medicine Products: