Navigation Links
Cancer-killing viruses influence tumor blood-vessel growth
Date:6/10/2008

COLUMBUS, Ohio Viruses genetically designed to kill cancer cells offer a promising strategy for treating incurable brain tumors such as glioblastoma, but the body's natural defenses often eliminate the viruses before they can eliminate the tumor.

The findings of an animal study by researchers at the Ohio State University Comprehensive Cancer Center help explain why this happens and could improve this therapy for brain cancer patients.

The research, published in the June 10 issue of the journal Molecular Therapy, shows that as the viruses destroy the tumor cells, they cause the cells to make proteins that stimulate the growth of new blood vessels to the tumor. These vessels transport immune cells that eradicate the viruses and actually stimulate regrowth of the tumor.

"This study points to an important side effect of oncolytic viral therapy that may limit its efficacy," says principal investigator Balveen Kaur, a researcher with Ohio State's Comprehensive Cancer Center and the Dardinger Laboratory for Neuro-oncology and Neurosciences.

"Knowing this, we can now work on designing a combination therapy that will inhibit this effect and enhance the action of the viral therapy."

The researchers also discovered that, in infected tumor cells, the viruses changed the activity levels of three genes linked to blood-vessel growth in gliomas.

One of these genes, CYR61, was nine times more active in virus-treated tumor cells than in uninfected tumors. The researchers also showed that the higher the dose of virus used, the greater the gene's activity.

For this study, Kaur and her colleagues implanted human glioma cells into rodents with a working immune system, then injected the resulting tumors of some with a cancer-killing, or oncolytic, virus called hrR3. The treated animals lived 17 days compared with 14 days for the untreated controls. The virus-treated tumors had roughly five times more blood vessels in them than the untreated
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Blood-vessel blocker aids cancer-killing virus
2. Virus Shows Some Cancer-Killing Abilities
3. How to design a cancer-killing virus
4. Self-assembled viruses
5. Monkey Gene That Blocks AIDS Viruses Evolved More Than Once
6. Researchers discover new battleground for viruses and immune cells
7. 6 simple steps to protect against and stop the spread of noroviruses
8. Researchers uncover more about how poxviruses evade the immune system
9. Viruses for a healthy pregnancy
10. McMaster test detects the most prevalent respiratory viruses
11. Common human viruses threaten endangered great apes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... (HealthDay News) -- People with the lowest incomes may have ... disease (PAD), a new study suggests. People with PAD ... limbs, most often the legs. The condition causes leg pain ... throughout the body. People with PAD have a higher risk ... nearly 6,800 people with PAD who took part in the ...
(Date:7/11/2014)... New York, NY (PRWEB) July 11, 2014 ... ( http://www.gynecaremorcellatorlawsuit.com/ ) investigation, Bernstein Liebhard LLP has ... U.S. Food & Drug Administration’s (FDA) Obstetrics ... to explore ways to mitigate the cancer risks ... minimally invasive gynecological surgeries. According to a report ...
(Date:7/11/2014)... July 11, 2014 Utilizing the Keller ... Dr. William Koenig, has topped a record number of ... has performed over 400 successful procedures without the occurrence ... is well known across the country for his expertise ... record has long been the foundation for numerous studies ...
(Date:7/11/2014)... July 11, 2014 (HealthDay News) -- U.S. health officials ... were exposed to live anthrax during a safety mishap ... Control and Prevention officials have announced a moratorium on ... high-level government labs. In a report issued Friday, ... to make sure a similar incident doesn,t occur again. ...
(Date:7/11/2014)... 11, 2014 According to a new ... Market by Communication Technology (ZigBee, Z-Wave, Bluetooth, Wi-Fi, NFC, ... Automotive & Transportation, Agriculture) & Geography - Global Trends ... Internet of Things market was worth $1029.5 Billion in ... 2020, at an estimated CAGR of 4.08% from 2014 ...
Breaking Medicine News(10 mins):Health News:Poor More Prone to Leg Circulation Trouble 2Health News:Morcellator Lawsuit News: Bernstein Liebhard LLP Notes Financial Ties Between FDA Advisory Panel Members and Manufacturers of Power Morcellators 2Health News:Morcellator Lawsuit News: Bernstein Liebhard LLP Notes Financial Ties Between FDA Advisory Panel Members and Manufacturers of Power Morcellators 3Health News:Morcellator Lawsuit News: Bernstein Liebhard LLP Notes Financial Ties Between FDA Advisory Panel Members and Manufacturers of Power Morcellators 4Health News:Rochester Surgeon Hits Milestone with Keller Funnel 2Health News:CDC Issues Tough Report on Anthrax Scare 2Health News:Internet of Things Technology & Application Market Worth $1423.09 Billion by 2020 – New Report by MarketsandMarkets 2Health News:Internet of Things Technology & Application Market Worth $1423.09 Billion by 2020 – New Report by MarketsandMarkets 3Health News:Internet of Things Technology & Application Market Worth $1423.09 Billion by 2020 – New Report by MarketsandMarkets 4
... working at the Swiss Institute for Experimental Cancer Research ... discovered that telomeres, the repeated DNA-protein complexes at the ... cell divides, also contain RNA. This discovery, published online ... understanding of how telomeres function, and may provide a ...
... Success of 2007 National IPF Awareness Week on ... Deadly Lung Disease, SAN JOSE, Calif., Oct. ... announced that the success of its fifth,annual National ... 60,members of Congress about the critical need to ...
... Oct. 4 The following statement was issued,today by ... and Janet,Jenner & Suggs, LLC: Out of public ... million,pound recall of potentially E. coli contaminated ground beef ... & SUGGS, LLC.,have established a registry for victims of ...
... Academy of General,Dentistry (AGD) was extremely disappointed by ... Health Insurance Program (SCHIP),reauthorization bill. The SCHIP bill ... included many important and beneficial dental,provisions intended to ... However, President Bush, who had threatened to veto ...
... provide tobacco cessation services for three more years, ... beBetter,Networks, Inc. (beBetter) has been awarded the West ... Health and Human Resources,for the Bureau for Public ... As the original vendor for the Quitline, beBetter ...
... canola,oil for common dietary fats in the U.S. ... and plant omega-3 fats,noted a modeling study published ... the American Dietetic Association (JADA). The study examined ... oils and canola oil-based,margarine for other margarines and ...
Cached Medicine News:Health News:New telomere discovery could help explain why cancer cells never stop dividing 2Health News:CPF Urges Congress to Increase Funding for IPF Research in 2009 Federal Budget 2Health News:CPF Urges Congress to Increase Funding for IPF Research in 2009 Federal Budget 3Health News:CPF Urges Congress to Increase Funding for IPF Research in 2009 Federal Budget 4Health News:Establishment of Topps Meat Recall Registry for Victims of E. Coli Poisoning 2Health News:Establishment of Topps Meat Recall Registry for Victims of E. Coli Poisoning 3Health News:AGD Concerned With Presidential Veto of SCHIP Reauthorization Bill 2Health News:AGD Concerned With Presidential Veto of SCHIP Reauthorization Bill 3Health News:beBetter Awarded WV Quitline Contract 2Health News:Canola Oil Can Help Americans Meet Dietary Fat Recommendations 2
(Date:1/15/2014)... 15, 2014 Most osteoporosis patients want a choice ... online survey* sponsored by Mission Pharmacal Company. The survey, ... Foundation online support community, revealed that 74 percent of ... in a form other than a pill or a ...
(Date:1/15/2014)... , Jan. 15, 2014 As health officials across the ... select Meijer pharmacies in Michigan will ... eligible patients, enabling Meijer pharmacists to administer tests and, in ... by a physician participating in the study. The ...
(Date:1/15/2014)... 2014  Novation, the leading health care supply chain expertise, ... reseller (VAR) national contracts that expand its portfolio to ... lower costs. These include manufacturer product and service agreements, ... and ongoing IT consulting support. New ...
Breaking Medicine Technology:Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2
... /PRNewswire-FirstCall/ --,NeurogesX, Inc. announced today the presentation of ... postherpetic neuralgia (PHN).,Misha-Miroslav Backonja, M.D., Professor of Neurology ... investigator in the,NeurogesX trial, plans to present the ... session at the Second International Congress on,Neuropathic Pain ...
... Reporting of COURAGE study results confused the public ... June 07, 2007 /PRNewswire/ -- The onslaught of,anti-stent ... shaped the,public's view that angioplasty doesn't work and ... patients have extensively,questioned their cardiologists about the benefits ...
Cached Medicine Technology:NeurogesX Announces Presentation of Positive Phase 3 Clinical Data,at the Second International Congress on Neuropathic Pain Meeting,(NeuPSIG) 2NeurogesX Announces Presentation of Positive Phase 3 Clinical Data,at the Second International Congress on Neuropathic Pain Meeting,(NeuPSIG) 3NeurogesX Announces Presentation of Positive Phase 3 Clinical Data,at the Second International Congress on Neuropathic Pain Meeting,(NeuPSIG) 4To Stent or Not: Is That the Question? 2
... Leica CM3050 S Cryostat Family ... excellent safety standards for practically ... The Leica CM3050 S is ... all cryosectioning research applications and ...
... 7500 is a freestanding cryostat with ... system and a radial cutting microtome. ... a wide range of specimens and ... use in high biohazard risk laboratories ...
... 560 Cryo-Star - a vision becomes ... which offer the users many benefits.,The ... cryostat with retraction that incorporates a ... and knife cooling. This facilitates applications ...
... sliding microtome with automatic fine/trim- feed ... Maintenance-free precision cross roller bearings. For ... applications in biological, botany, and materials ... x 90 mm can be accommodated. ...
Medicine Products: