Navigation Links
Cancer-killing compound spares healthy cells
Date:1/4/2012

This press release is available in French.

Montreal -- Lithocholic acid (LCA), naturally produced in the liver during digestion, has been seriously underestimated. A study published in the journal Oncotarget shows that LCA can kill several types of cancer cells, such as those found in some brain tumors and breast cancer.

The research team, led by Concordia University, included scientists from McGill University and the Jewish General Hospital's Lady Davis Institute in Montreal as well as the University of Saskatchewan.

Previous research from this same team showed LCA also extends the lifespan of aging yeast. This time, the team found LCA to be very selective in killing cancer cells while leaving normal cells unscathed. This could signal a huge improvement over the baby-with-the-bathwater drugs used in chemotherapy.

"LCA doesn't just kill individual cancer cells. It could also prevent the entire tumor from growing," says senior author Vladimir Titorenko, a professor in the Department of Biology and Concordia University Research Chair in Genomics, Cell Biology and Aging.

What's more, LCA prevents tumors from releasing substances that cause neighboring cancer cells to grow and proliferate. Titorenko says LCA is the only compound that targets cancer cells, which could translate into tumor-halting power.

"This is important for preventing cancer cells from spreading to other parts of the body," he says, noting that unlike other anti-aging compounds, LCA stops cancer cell growth yet lets normal cells continue to grow.

A wide effect on different types of cancers

The next step for the research team will be to test LCA's effect on different cancers in mice models. Titorenko expects that LCA will also kill cancer cells in those experiments and lead to human clinical trials. "Our study found that LCA kills not only tumors (neuroblastomas), but also human breast cancer cells," says Titorenko. "This shows that it has a wide effect on different types of cancers."

Titorenko emphasizes that unlike drugs used in chemotherapy, LCA is a natural compound that is already present in our bodies. Studies have shown that LCA can be safely administered to mice by adding it to their food. So why is LCA so deadly for cancer cells? Titorenko speculates that cancer cells have more sensors for LCA, which makes them more sensitive to the compound than normal cells.

LCA sensors send signals to mitochondria the powerhouses of all cells. It seems that when these signals are too strong, mitochondria self-destruct and bring the cell down with them. Simply put, Titorenko and his colleagues engaged in cancer cell sabotage by targeting a weakness to LCA.


'/>"/>
Contact: Nadia Kherif
Nadia.Kherif@concordia.ca
514-848-2424 x4187
Concordia University
Source:Eurekalert

Related medicine news :

1. Cancer-killing cells are caught on film in more 3-D detail than ever before
2. Compound enhances cancer-killing properties of agent in trials
3. BUSM researchers identify novel compound to halt virus replication
4. Tumor-targeting compound points the way to new personalized cancer treatments
5. New compound defeats drug-resistant bacteria
6. Dual-acting class of antimalarial compounds discovered by Novartis with potential to prevent and treat malaria
7. Scripps Research scientists identify new class of antimalarial compounds
8. Compound found in common wart treatment shows promise as leukemia therapy
9. Mushroom compound appears to improve effectiveness of cancer drugs
10. Magic Mushroom Compound Triggered Positive Personality Change in Study
11. NYU researchers develop compound to block signaling of cancer-causing protein
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/16/2018)... ... , ... Solo Printing, a Miami-based commercial printing company, is giving back to ... around Latin America with access to clean water and sanitation. , BLUE Missions ... the overall quality of life in rural communities. The non-profit believes water is the ...
(Date:12/14/2018)... ... December 14, 2018 , ... ... company, which has pending lawsuits that claim its talc powder has toxic ingredients ... results for asbestos in its baby powder. The documents also show our competitor's ...
(Date:12/14/2018)... ... December 14, 2018 , ... The Parenteral Drug Association (PDA) ... January 1, 2019. In the fall of 2018, PDA’s 10,500 members had an opportunity ... been elected/appointed as Directors to the PDA Board of Directors for three-year terms starting ...
(Date:12/14/2018)... ... , ... Bathing can be very dangerous for seniors and people suffering from ... the bathroom for seniors 65 and older, according to The National Council of Aging. ... or distributing walk-in tubs and bath accessories. Following these tips may help decrease the ...
(Date:12/13/2018)... ... 2018 , ... Ross A. Clevens, MD, FACS is the only physician in ... the highest-rated and most active doctors on RealSelf , the leading online marketplace ... been named a “Distinguished Inductee,” a distinction reserved for the top 25 percent of ...
Breaking Medicine News(10 mins):
(Date:12/10/2018)... ... , ... Mothers Against Drunk Driving (MADD) announces its new National President, Helen ... Helen Marie, was killed by a drunk and drugged driver while rollerblading on a ... , “I landed in MADD’s capable lap, completely shattered,” Witty said. “I cherish the ...
(Date:12/10/2018)... ... December 10, 2018 , ... ... HREI, (651) 214-9987, cmccaffrey(at)wolfmarketing.com , Healthcare Real Estate Insights™ magazine has announced the ... to recognizing excellence in the areas of healthcare real estate (HRE) development ...
(Date:12/8/2018)... ... December 07, 2018 , ... Nationally, it is estimated that 114 million ... benefits that are seriously lacking and make it challenging to get needed care. ... care should be accessible and affordable to everyone, with or without dental insurance. ...
Breaking Medicine Technology: