Navigation Links
Cancer gene drives pivotal decision in early brain development
Date:11/13/2007

trochemical signals that they exchange with each other.

For answers, Gutmann and his colleagues turned to neural stem cells, the progenitor cells that give rise to neurons and astrocytes in the brains of developing embryos. Researchers led by Balazs Hegedus, Ph.D., a postdoctoral fellow, developed a line of mice in which they could selectively disable the mouse equivalent of the human NF1 gene, Nf1, in neural stem cells. Studies of these mice revealed that the Nf1 protein, neurofibromin, controls the activity of two signaling pathways, the cyclic adenosine monophosphate (cAMP) pathway and the Ras pathway. This allows neurofibromin to regulate the development of both neurons and astrocytes.

"We found that neurofibromin regulation of the Ras pathway is essential for the development of astrocytes, but not for neurons," Gutmann explains. "The opposite was true of the cAMP pathway the effect of neurofibromin on cAMP signaling was critical for neurons but not for astrocytes."

Gutmann suggests the search for treatments for neurofibromatosis type 1 should branch out along a similar dual track.

"For patients with brain tumors, we probably need to focus on identifying new or existing treatments that normalize Ras pathway activity," Gutmann says. "To treat the learning disabilities, we probably need to focus on the cAMP pathway."

More details of the molecular mechanisms that push neural stem cells onto the paths to becoming an astrocyte or a neuron may potentially be useful for understanding other developmental disorders of the brain, according to Gutmann.

He and his colleagues plan to use this unique mouse model that lets them selectively disable Nf1 in brain progenitor cells to better understand the causes of neurofibromatosis type 1-related learning disabilities. Anatomically, the brains of neurofibromatosis type 1 patients contain no obvious structural defects that readily explain why the majority of children with the condition have learning
'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University in St. Louis
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Survival differences by race most apparent in advanced stages of breast cancer
3. MRI finds breast cancer before it becomes dangerous
4. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
5. Pathway links inflammation, angiogenesis and breast cancer
6. Radiologists encouraged to look beyond cancer for clinically unseen diseases
7. Diet high in meat, fat and refined grains linked to risk for colon cancer recurrence, death
8. Immune deficiency linked to a type of eye cancer
9. Drop in breast cancer incidence linked to hormone use, not mammograms
10. Breast cancer prevention practices vary across Canada
11. First biomarker discovered that predicts prostate cancer outcome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2015)... “ Food Cost Calculator ” was featured ... a look at the latest and coolest applications on the ... of AppWatch and technology expert, conducted the app review and ... manage and efficiently calculate food costs. , The restaurant industry ... the industry has an estimated 1.8 trillion dollar impact on ...
(Date:5/4/2015)... (PRWEB) May 04, 2015 ... just released the first-ever congenital heart disease ... Catheterization Laboratory (PCCL) accreditation. Driven by the ... are a comprehensive review of interventional procedures ... heart disease. , “The ACE CHD Standards ...
(Date:5/4/2015)... “St. Louis has long represented opportunity and ... so it is the perfect place for Zerorez to ... Litalien, Chief Development Officer for Zerorez. “We have ... provide veterans with a $10,000 discount on our franchise ... a number of Military Veterans in its ranks including ...
(Date:5/4/2015)... (PRWEB) May 04, 2015 Sara Soulati, ... physician practice management firm in Los Angeles associated with ... the patent-pending status of The Sara Soulati Health For ... in 2010, is a lifestyle modification and disease prevention ... 2015 to the U. S. Patents and Trademarks Office ...
(Date:5/3/2015)... Birmingham, Lake Orion, Clarkston, Metamora, Michigan (PRWEB) May 03, 2015 ... . She has worked to enhance the well being of ... as a generalist in a hospital, followed by providing care for ... I worked with as an Adult Nurse Practitioner began wondering if ... coupled with the birth of my own children with my mentor ...
Breaking Medicine News(10 mins):Health News:An Application to Manage a Successful Restaurant Was Featured on NewsWatch Television 2Health News:Accreditation for Cardiovascular Excellence (ACE) Publishes New Standards for Pediatric and Adult Congenital Cardiac Catheterization Laboratories 2Health News:Zerorez® Creates “Gateway” for Veterans--Announces VetFran Participation. Plans Expansion into the St. Louis Region. 2Health News:Zerorez® Creates “Gateway” for Veterans--Announces VetFran Participation. Plans Expansion into the St. Louis Region. 3Health News:CEO Sara Soulati Announces Patent-Pending Designation For The Sara Soulati Health For Life Program 2Health News:Women's Excellence In Midwifery Welcomes Barbara Crone 2
... thirty poor women of the fishing community, living on Chennai’s ... The 1994 Transplant of Human Organ Act ... to donate kidneys for transplantation. However a recent report from ... that several leading hospitals in the state encouraged the economically ...
... 50% of sexually active gay men in the UK had unprotected ... the 2005 Gay Men’s Sex Survey//, Consuming Passions, which has been ... of gay men in the UK are unaware of their own ... not disclosed their HIV infection status. ,The study ...
... on 4,000 pregnant women one-fifth of them had to undergo ... failed//. Researchers found that obesity impairs the ability of the ... and deliver the baby. ,In a study of ... overweight women had to undergo an emergency Caesarean Section birth ...
... the Virginia Tech sure had the whole world reaching out ... //An incident unbelievable, the shooting had aftermaths throughout the world. ... family of the people who died at the university. ... to come to term with the whole incident. It will ...
... fetuses could survive. And they have, one in thirty. Such ... hospitals. // ,Most of these babies with ... and all lived for no more than a few hours, ... Obstetrics and Gynaecology study. ,About 190,000 abortions take ...
... one is aware that strawberries are good for health. ... form makes it healthier. // ,While exploring ... from Thailand and the US discovered that treating the ... capacity and free radical scavenging activity within the fruit. ...
Cached Medicine News:Health News:Kidney Trade: Curbing the Sale 2Health News:Kidney Trade: Curbing the Sale 3Health News:One-fifth of Obese Women Undergo Caesarean Due to Uterus Failure 2Health News:Support for Trauma and Grief 2Health News:Aborted Babies Survive, a British Study Says 2
(Date:5/4/2015)... BioPharma Inc. (NASDAQ: ARRY ) today reported ... year ending June 30, 2015. Ron ... close of the Novartis-GSK transaction, Array now owns ... in Phase 3, with plans for regulatory submissions ... have accelerated our path to commercialization and provide ...
(Date:5/3/2015)... , May 4, 2015 A new ... and families to reduce asthma-related illness. ... that pharmacies in neighborhoods with high rates of ... controller medications compared to asthma rescue medications. ... living in poverty or with limited access to ...
(Date:5/1/2015)... 1, 2015 Hitachi Chemical Diagnostics, Inc. is ... launch of the ExoComplete™ 96-Well Plate Kit and ... for exosome collection to mRNA purification.  The products were ... Annual Meeting, April 23 – 26, 2015, in ... for research use only of molecular biology applications and ...
Breaking Medicine Technology:Array BioPharma Reports Financial Results For The Third Quarter Of Fiscal 2015 2Array BioPharma Reports Financial Results For The Third Quarter Of Fiscal 2015 3Array BioPharma Reports Financial Results For The Third Quarter Of Fiscal 2015 4Array BioPharma Reports Financial Results For The Third Quarter Of Fiscal 2015 5Array BioPharma Reports Financial Results For The Third Quarter Of Fiscal 2015 6Array BioPharma Reports Financial Results For The Third Quarter Of Fiscal 2015 7Array BioPharma Reports Financial Results For The Third Quarter Of Fiscal 2015 8Array BioPharma Reports Financial Results For The Third Quarter Of Fiscal 2015 9Array BioPharma Reports Financial Results For The Third Quarter Of Fiscal 2015 10New Study Suggests Prominent Role for Pharmacies In Reducing Asthma-related Illness 2New Study Suggests Prominent Role for Pharmacies In Reducing Asthma-related Illness 3New Products for Exosome Isolation to mRNA Purification 2
... NeurogesX, Inc. (Nasdaq: NGSX ), a biopharmaceutical ... announced that it has entered into a $20 million ... HTGC).  The loan agreement includes both a $5 million ... term loan. Proceeds are expected to be ...
... Aug. 8, 2011 Global Health Ventures Inc. ... on sublingual drug delivery announced today that their August ... and CEO, is available for on-demand viewing. ... watch event now" button. Their presentation will ...
Cached Medicine Technology:NeurogesX, Inc. Secures $20 Million Debt Facility 2NeurogesX, Inc. Secures $20 Million Debt Facility 3NeurogesX, Inc. Secures $20 Million Debt Facility 4Global Health Ventures August 4th Investor Presentation Now Available for On-demand Viewing at RetailInvestorConferences.com 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: