Navigation Links
Cancer drugs my build and not tear down blood vessels
Date:11/9/2008

Scientists have thought that one way to foil a tumor from generating blood vessels to feed its growth a process called angiogenesis was by creating drugs aimed at stopping a key vessel growth-promoting protein. But now the opposite seems to be true.

Researchers at the Moores Cancer Center at the University of California, San Diego (UCSD) in La Jolla have found evidence that blocking that protein target, called VEGF, or vascular endothelial growth factor, doesn't really halt the process at all. Instead, cutting levels of VEGF in a tumor actually props up existing blood vessels, making them stronger and more normal, and in some cases the tumors larger. But as a result, the tumor is more vulnerable to the effects of chemotherapy drugs.

In a paper appearing online November 9, 2008 in the journal Nature, David Cheresh, Ph.D., professor and vice chair of pathology at the UC San Diego School of Medicine and the Moores UCSD Cancer Center and his co-workers mimicked the action of anti-angiogenesis drugs by genetically reducing VEGF levels in mouse tumors and inflammatory cells in various cancers, including pancreatic cancer. They also used drugs to inhibit VEGF receptor activity. In every case, blood vessels were made normal again.

The researchers say the findings provide an explanation for recent evidence showing that anti-angiogenesis drugs such as Avastin can be much more effective when combined with chemotherapy. The results may lead to better treatment strategies for a variety of cancers.

"We've discovered that when anti-angiogenesis drugs are used to lower the level of VEGF within a tumor, it's not so much a reduction in the endothelial cells and losing blood vessels as it is an activation of the tumor blood vessels supporting cells," said Cheresh. "This enables vessels to mature, providing a conduit for better drug delivery to the tumor. While the tumors initially get larger, they are significantly more sensitive
'/>"/>

Contact: Steve Benowitz
sbenowitz@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Cost of treating colorectal cancer can vary by thousands per patient
2. Barry Manilow Brings Valentines and Music to New York With Concert to Raise Funds for Breast Cancer Research
3. AMA Immediate Past President Ron Davis Loses Battle With Cancer, Leaves Enduring AMA and Public Health Legacy
4. ESF workshop makes major advance in cancer radiotherapy
5. More People Living Longer After Cancer Diagnosis
6. Researchers find predictive tests and early treatment delay progression of blood cell cancer
7. Negative Cancer Messages Backfire With Blacks
8. Lung Cancer Alliance-Georgia Issues Third Annual State-Specific Report Card on Lung Cancer
9. Free Web Site Lists Breast Cancer Clinical Trials
10. Lung Cancer Alliance Releases 4th Annual Report Card on Lung Cancer
11. Migraine Might Lower Breast Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... 2014 The Pearland, Texas location of The ... from four months to 12 years of age that offers ... birthday parties and Summer Camps, is now under new ownership. ... Pearland after spending over six years at The Little ... Director. , Berry has over ten years of experience ...
(Date:7/13/2014)... July 13, 2014 The federal court ... ) filed against Johnson & Johnson’s Ethicon, Inc. ... which is expected to get underway next month. According ... U.S. District Court, Southern District of West Virginia on ... on August 7, 2014 at 3:00 p.m. July selection ...
(Date:7/13/2014)... Max International has recently ... be the featured guest at its Charity Exhibition and ... Attendees will learn about Max’s health products and ... basketball games and perform in a 3 point shoot-out. ... and energy-boosting supplements , has recently announced former NBA ...
(Date:7/13/2014)... Fadhits.com is popular among worldwide women. Its lace ... Recently, the company has announced its new selection of ... all these outfits are available at discounted prices (from ... supplier is now offering similar discounts for many other ... many other designs for sale, including flower girl dresses, ...
(Date:7/13/2014)... ANGELES A noninvasive optical imaging device developed ... that later occur in the brain and are ... preliminary results from investigators conducting a clinical trial ... findings July 15 in an oral presentation at ... Denmark. They also were invited by conference organizers ...
Breaking Medicine News(10 mins):Health News:The Little Gym of Pearland, TX Now Under New Ownership and Management 2Health News:Ethicon Vaginal Mesh Lawsuits Move Forward, As Federal Court Schedules Pretrial Conference for Second Bellwether Case, Bernstein Liebhard LLP Reports 2Health News:Ethicon Vaginal Mesh Lawsuits Move Forward, As Federal Court Schedules Pretrial Conference for Second Bellwether Case, Bernstein Liebhard LLP Reports 3Health News:Ethicon Vaginal Mesh Lawsuits Move Forward, As Federal Court Schedules Pretrial Conference for Second Bellwether Case, Bernstein Liebhard LLP Reports 4Health News:Max International Announces NBA Dream Team Member Chris Mullin as Featured Guest of Charity Event 2Health News:Max International Announces NBA Dream Team Member Chris Mullin as Featured Guest of Charity Event 3Health News:Max International Announces NBA Dream Team Member Chris Mullin as Featured Guest of Charity Event 4Health News:Fadhits.com Announces a Special Offer on Elegant Quinceanera Dresses 2Health News:Study of noninvasive retinal imaging device presented at Alzheimer's conference 2Health News:Study of noninvasive retinal imaging device presented at Alzheimer's conference 3
... -- Most children born with HIV infection now survive ... death that awaited HIV-infected babies years ago, researchers report. ... AIDS-causing virus, to better understand the effects of treatment ... these kids, at this point, don,t have virus detectable ...
... Associations for Dental Research (IADR/AADR) have published two studies ... income individuals. These articles, titled "Income-related Inequalities in Dental ... and "Income Inequality and Tooth Loss in the United ... in the Journal of Dental Research, the official publication ...
... By Dennis Thompson HealthDay Reporter , ... and the American Heart Association have put forth an ... attack, stroke and coronary heart disease. The goals ... and illness, however. They place even greater emphasis on ...
... Columbia Business School is proud to announce that Frank ... Finance and Economics and the Healthcare and Pharmaceutical Management ... by the Emerald Literati Network. The award recognizes an ... book series published by Emerald Group Publishing, a leading ...
... , FRIDAY, April 22 (HealthDay News) -- Lynne Braun spends a ... by their hearts and their health. Braun, who works as ... teaches at the university,s College of Nursing, helps counsel people who ... who,ve had a heart attack or stroke and hope to ...
... Healthcare today teleconferenced one of the world,s first live ... to conference attendees in Sao Paolo, Brazil. The meeting, ... of the globe,s largest vascular surgery events and includes ... an endograft device called a repositionable endoprosthesis. ...
Cached Medicine News:Health News:HIV Kids Growing Up Well, Study Finds 2Health News:IADR/AADR Journal of Dental Research releases studies on oral health inequalities in older people 2Health News:To Get Americans Healthier, U.S. Targets the Heart 2Health News:To Get Americans Healthier, U.S. Targets the Heart 3Health News:To Get Americans Healthier, U.S. Targets the Heart 4Health News:Columbia business school’s Frank Lichtenberg awarded by the Emerald Literati Network 2Health News:Nurse Practitioner Counsels Lifestyle Changes as Key to Heart Health 2Health News:Nurse Practitioner Counsels Lifestyle Changes as Key to Heart Health 3Health News:Scott & White Healthcare broadcasts live surgery to São Paolo, Brazil 2
(Date:7/10/2014)... , July 10, 2014  Valeant Pharmaceuticals International, ... today announced it has completed the sale to Galderma ... Dysport owned or held by Valeant for $1.4 billion ... Nestle S.A, which recently completed its acquisition of Galderma. ... divestiture of our products to a company that is ...
(Date:7/10/2014)... July 10, 2014 CVS Caremark Corporation (NYSE: ... has approved a quarterly dividend of $0.275 (27.5 cents) per ... on August 1, 2014, to holders of record on July ... CVS Caremark is dedicated to helping people on their path ... the United States . Through the company,s ...
(Date:1/15/2014)... Most osteoporosis patients want a choice in the medication ... by Mission Pharmacal Company. The survey, conducted by ... community, revealed that 74 percent of osteoporosis patients surveyed ... other than a pill or a tablet. ...
Breaking Medicine Technology:Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3
... 26, 2011 Vapotherm announced today the launch ... specifically for homecare and other low acuity environments. ... and European markets. Vapotherm,s Flowrest® ... home and other extended care environments.  According to ...
... 26, 2011 Omnicell, Inc . (NASDAQ: ... medication and supply management solutions and analytics software ... Victoria Hospital (RVH) selected Omnicell G4 solutions ... by Omnicell,s hallmark flexibility and functionality, RVH became ...
Cached Medicine Technology:Vapotherm Announces Commercial Launch of Flowrest® Homecare Device 2Royal Victoria Hospital Selects Omnicell to Improve Patient Safety with Automated Medication Management 2Royal Victoria Hospital Selects Omnicell to Improve Patient Safety with Automated Medication Management 3Royal Victoria Hospital Selects Omnicell to Improve Patient Safety with Automated Medication Management 4
... Maximum Xtra, and Maximum ACT introducers ... and specialty hemostasis introducers in the ... premier hemostasis introducers for use in ... angiography, angioplasty, stenting, atherectomy, temporary pacing, ...
St. Jude Medical's line of guiding introducers includes Swartz Series, SAFL, SEPT, CSTA, RAMP, and 2 piece steerable...
The intended use of the percutaneous PREFACE Guiding Sheath is for the introduction of intravascular electrophysiology catheters into any cardiac chamber....
... EP Systems sells the popular transeptal ... needles. These products allow left atrial ... catheter ablation of left-sided arrhythmogenic substrates. ... others use it when a transaortic ...
Medicine Products: