Navigation Links
Cancer drugs my build and not tear down blood vessels
Date:11/9/2008

Scientists have thought that one way to foil a tumor from generating blood vessels to feed its growth a process called angiogenesis was by creating drugs aimed at stopping a key vessel growth-promoting protein. But now the opposite seems to be true.

Researchers at the Moores Cancer Center at the University of California, San Diego (UCSD) in La Jolla have found evidence that blocking that protein target, called VEGF, or vascular endothelial growth factor, doesn't really halt the process at all. Instead, cutting levels of VEGF in a tumor actually props up existing blood vessels, making them stronger and more normal, and in some cases the tumors larger. But as a result, the tumor is more vulnerable to the effects of chemotherapy drugs.

In a paper appearing online November 9, 2008 in the journal Nature, David Cheresh, Ph.D., professor and vice chair of pathology at the UC San Diego School of Medicine and the Moores UCSD Cancer Center and his co-workers mimicked the action of anti-angiogenesis drugs by genetically reducing VEGF levels in mouse tumors and inflammatory cells in various cancers, including pancreatic cancer. They also used drugs to inhibit VEGF receptor activity. In every case, blood vessels were made normal again.

The researchers say the findings provide an explanation for recent evidence showing that anti-angiogenesis drugs such as Avastin can be much more effective when combined with chemotherapy. The results may lead to better treatment strategies for a variety of cancers.

"We've discovered that when anti-angiogenesis drugs are used to lower the level of VEGF within a tumor, it's not so much a reduction in the endothelial cells and losing blood vessels as it is an activation of the tumor blood vessels supporting cells," said Cheresh. "This enables vessels to mature, providing a conduit for better drug delivery to the tumor. While the tumors initially get larger, they are significantly more sensitive
'/>"/>

Contact: Steve Benowitz
sbenowitz@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Cost of treating colorectal cancer can vary by thousands per patient
2. Barry Manilow Brings Valentines and Music to New York With Concert to Raise Funds for Breast Cancer Research
3. AMA Immediate Past President Ron Davis Loses Battle With Cancer, Leaves Enduring AMA and Public Health Legacy
4. ESF workshop makes major advance in cancer radiotherapy
5. More People Living Longer After Cancer Diagnosis
6. Researchers find predictive tests and early treatment delay progression of blood cell cancer
7. Negative Cancer Messages Backfire With Blacks
8. Lung Cancer Alliance-Georgia Issues Third Annual State-Specific Report Card on Lung Cancer
9. Free Web Site Lists Breast Cancer Clinical Trials
10. Lung Cancer Alliance Releases 4th Annual Report Card on Lung Cancer
11. Migraine Might Lower Breast Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... PA (PRWEB) September 21, 2014 "I ... their legs and back but haven’t the money for ... I’d like to have such a product for myself." ... effective way to stretch the thigh muscles and align ... as well as relieves discomfort of pinched nerves. Compact ...
(Date:9/21/2014)... Best Cheap Hosting USA, one of ... Bluehost and GreenGeeks are the best Reseller hosting suppliers ... reseller hosting supplier. Actually, these companies have outperformed their ... support. People can get the best web hosting at ... According to the manager, reseller hosting is a very ...
(Date:9/21/2014)... (PRWEB) September 21, 2014 To accommodate ... e-powered platform and provide more trendy items. Recently, the ... . By offering the new and elegant wedding gowns, ... get what they need in an easy way. Its ... deeply discounted rates, from 12% off to 62% off. ...
(Date:9/21/2014)... 21, 2014 “Cluster headaches are sometimes ... and difficult to resolve,” said Steve Young of Ew ... of a pain that is more intense.” , “It ... cluster headaches, or migraines, that medical research is pointing ... system,” he added. , Serotonin (5-HT, 5-hydroxytryptamine) is a ...
(Date:9/21/2014)... C8 lawsuits move forward in the ... list of 20 possible C8 lawsuits selected for ... reports Wright & Schulte LLC. Court records show these ... C8 lawsuits filed that represent individuals who purportedly developed ... result of being exposed to water contaminated by the ...
Breaking Medicine News(10 mins):Health News:Best Cheap Hosting USA Announces The Best Reseller Hosting Suppliers In 2014 2Health News:Angeldress.co.uk Launches New Range Of 2014 Vintage Wedding Dresses In Its Online Store 2Health News:Homeostasis: Equinox Serotonin (5HT) Headache Stories ~ New on the Bryan William Brickner Blog 2Health News:C8 Lawsuit Claims Move Forward as Six Possible Cases for Bellwether Trials Selected in DuPont Water Contamination Lawsuits, Reports Wright & Schulte LLC 2Health News:C8 Lawsuit Claims Move Forward as Six Possible Cases for Bellwether Trials Selected in DuPont Water Contamination Lawsuits, Reports Wright & Schulte LLC 3Health News:C8 Lawsuit Claims Move Forward as Six Possible Cases for Bellwether Trials Selected in DuPont Water Contamination Lawsuits, Reports Wright & Schulte LLC 4
... Washington Teenage girls are setting new trends in drug ... , a report has shown. ,Teen boys have ... Wanting a slice of the vice, teen girls have become ... drugs, according to the White House Office of National Drug ...
... finds that sleep deprivation can adversely affect a persons ... of gains and making light of ones losses ... neural underpinnings of risky decision making under conditions of ... studied healthy volunteers as they underwent functional magnetic resonance ...
... not get training posts through the flawed Medical Training ... government is stalling on a new contract for ... figures show that 34,250 doctors are chasing 18,500 specialist ... far given no commitment that trainee doctors will be ...
... definite link between pregnancy, migraine and stroke, US researchers ... one. ,In fact, Cheryl Bushnell, assistant professor ... Disease in Durham, explained that pregnant women who suffered ... than pregnant women who did not suffer migraine. ...
... Science & Technology, Government of India and the ... today to address a major obstacle in AIDS ... elicit neutralizing antibodies against HIV. A new Indian ... and the Department of Biotechnology, will comprise top ...
... disturbing link between Reclast, made by Novartis AG and Fosamax manufactured ... in a small number of women users. Both are known bone-building ... more pronounced with Reclast, given as an annual shot. But there ... took the leading osteoporosis pill, Fosamax by Merck & Co. They ...
Cached Medicine News:Health News:Sleep Deprivation can Affect Competent Decision-making 2Health News:Junior Doctors Facing More Misery Because of Contract Deadlock: BMA 2Health News:DBT And IAVI Forge Partnership To Develop Next Generation Vaccine Candidates 2Health News:DBT And IAVI Forge Partnership To Develop Next Generation Vaccine Candidates 3Health News:Anti-osteoporosis Drugs Could Result in Irregular Heart Rhythm, New Study 2
(Date:9/19/2014)... , Sept. 19, 2014 Medical science ... relationships with key opinion leaders (KOLs) who can ... Despite the critical nature of the MSL function, ... including altering the landscape for creating and maintaining ... to research, the oversight responsibility for the MSL ...
(Date:9/19/2014)... 2014  Today DePuy Synthes Companies of Johnson ... systems featuring its proprietary variable angle locking technology. ... to match patient anatomy and fracture pattern and ... systems are being introduced in conjunction with the ... the International Federation of Foot & Ankle Societies ...
(Date:9/19/2014)... , Sept. 19, 2014 /PRNewswire-iReach/ -- ... Oxybutynin Hydrochloride Industry, 2009-2019 is a professional ... Chinese Oxybutynin Hydrochloride industry. The report firstly ... including its classification, application and manufacturing technology. ... top manufacturers of Oxybutynin Hydrochloride listing their ...
Breaking Medicine Technology:Role of Medical Science Liaisons Shifting in Healthcare Industry 2DePuy Synthes Proprietary Variable Angle Locking Technology Now Available To Treat Calcaneal Fractures And Medial Column Fusion Procedures 2DePuy Synthes Proprietary Variable Angle Locking Technology Now Available To Treat Calcaneal Fractures And Medial Column Fusion Procedures 3Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 2Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 3Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 4Oxybutynin Hydrochloride Industry 2014-2019 Chinese Forecasts & Analysis 5
... Sept. 21, 2011 Mylan Inc. (Nasdaq: ... a settlement and license agreement with Hoffman La Roche ... and 500 mg, USP, known generically as Capecitabine Tablets. ... in the treatment of metastatic breast and colorectal cancers. ...
... At Home Healthcare, a leading provider of home ... with Cardiocom to provide advanced home telehealth technology to ... a world class developer, manufacturer and clinical service provider ... to provide superior home care and to ensure the ...
Cached Medicine Technology:Mylan Announces XELODA® Settlement and License Agreement 2At Home Healthcare Expands Telehealth Program With Cardiocom® Telehealth Technology 2
Alexander periosteal elevators....
Lambotte periosteal elevators....
Cottle periosteal & skin elevator, 7 1/2", slightly curved blade, 9 mm wide....
Dolwick-Reich Condyle periosteal elevator, 17.5 cm, 7"....
Medicine Products: