Navigation Links
Cancer drug shows promise for treating a wide range of inflammatory diseases
Date:6/30/2010

Those looking for a new treatment for a range of inflammatory diseases like arthritis, multiple sclerosis, inflammatory bowel disease, and lupus may need to look no further than a drug already available for treating cancer. In a research report published in the July 2010 print issue of the Journal of Leukocyte Biology (http://www.jleukbio.org), Japanese scientists use mice to show that bortezomib, currently used to treat cancers that affect white blood cells, induces cell death only in harmful (active and proliferating) T cells, leaving the rest unharmed. If the results prove true in humans, it offers hope that this drugs or others similar to it might be used to treat inflammatory diseases without the side effects of current drugs that affect all T cells equally.

"Unfortunately, there are a lot of people who are suffering from autoimmune and inflammatory disease," said Koichi Yanaba, M.D., Ph.D., a scientist from the Department of Dermatology at Nagasaki University Graduate School of Biomedical Sciences who was involved in the research. "We believe that this new-type remedy for autoimmune and inflammatory disease could successfully treat them in the near future."

To make this discovery, scientists used two groups of micethe first treated with bortezomib and the second with saline. Researchers induced contact hypersensitivity reaction with oxazolone, a chemical allergen used for immunological experiments and found that bortezomib significantly inhibited the contact hypersensitivity responses. Results strongly suggest that bortezomib treatment enhanced T cell death by inhibiting NF-kappa B activation, which plays a key role in regulating the immune response to infection. This in turn led to the suppression of inflammatory responses in immune cells by reducing interferon-gamma production.

"Any time you learn that a drug already on the market has the potential to be used for more illnesse
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. A key mechanism links virgin olive oil to protection against breast cancer
2. Interventions to promote repeat breast cancer screening with mammography
3. Smoking-related colorectal cancer in older women is associated with molecularly-defined DNA changes
4. Researchers suggest new paradigm for breast cancer screening
5. Smoking May Boost Risk of Certain Colon Cancers
6. Study shows how dietary supplement may block cancer cells
7. Statins May Lower Rates of Prostate Cancer Recurrence
8. Fewer than half of breast cancer patients adhere to hormonal therapy regimen, study finds
9. Bursting bubbles with sound offers new treatments for cancer
10. More than a million parents with minor children are cancer survivors
11. A New Approach to Quantifying Risk of Developing Lung Cancer is published in Academic Radiology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... 2015 Riviera Magazine has ... of the Gallery of Cosmetic Surgery in Newport ... experts. The publication focused on his expertise in ... fat grafting, eyelid surgery, laser resurfacing and rhinoplasty. , ... has resulted in thousands of satisfied patients across ...
(Date:4/17/2015)... have seen healing, a lot of healing, and a lot ... Kafader of Friendship Village. “People have found purpose. ... have created beautiful pieces of art.” For the past eight ... was launched to benefit residents of the retirement community. , ... Institute in Chicago, worked as an intern at Friendship Village, ...
(Date:4/17/2015)... (PRWEB) April 17, 2015 Consumers who ... protection without modifications can now use the Insurance Pros ... life insurance policy rates that are featured by leading ... standard plans that are offered are mixed between three ... 18 to 79. There are now term, universal and ...
(Date:4/17/2015)... 17, 2015 As a board-certified orthopedic ... new offering of platelet-rich plasma (PRP) and ... is known for its world-class care of injury-caused ... surgical experience lacking in many other physicians offering regenerative ... are utilized for pain management and rehabilitation. Dr. Meier ...
(Date:4/17/2015)... 17, 2015 Testosterone treatment lawsuits ... of prescription medications increases the likelihood that a ... other life-threatening cardiovascular event continue to mount in ... Northern District of Illinois. According to an updated ... on Multidistrict Litigation (JPML) on April 15th, 1,382 ...
Breaking Medicine News(10 mins):Health News:Orange County Facial Plastic Surgeon Featured in Premier Magazine Focused on Beauty 2Health News:Orange County Facial Plastic Surgeon Featured in Premier Magazine Focused on Beauty 3Health News:Healing At Friendship Village Due To Art Therapy 2Health News:General Life Insurance Policy Rates Added to Quotation System at Insurance Website Online 2Health News:Platelet-Rich Plasma, Stem Cell Therapy Now Offered By Dr. Meier At MOSM in Beverly Hills, California 2Health News:Platelet-Rich Plasma, Stem Cell Therapy Now Offered By Dr. Meier At MOSM in Beverly Hills, California 3Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 2Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 3Health News:Testosterone Treatment Lawsuits Increase, as New Report Indicates Over 200 Federal Cases Filed Since March 4
... in those with airway disease, , THURSDAY, March 4 (HealthDay ... breathe, it may also make you more prone to developing ... more than twice as likely to have depression or anxiety ... to a report in the March issue of the journal ...
... ... in favor of their ability to get low cost medication, PharmacyChecker.com launched a new ... against consumer access to Canadian and foreign online pharmacies: The Partnership for Safe Medicines ... ...
... ... ... , ... , , , , ...
... , ... , ... , , , , ... ...
... ... ... ... ...
... advances in drug development, genetics and multidisciplinary treatment have brought ... Rafael Rosell from the Catalan Institute of Oncology in Badalona, ... which will be held in Geneva, Switzerland from 28 April ... expected at the conference, which is a joint initiative of ...
Cached Medicine News:Health News:People With Asthma More Likely to Be Depressed 2Health News:People With Asthma More Likely to Be Depressed 3Health News:PharmacyChecker.com Begins Blog About Americans' Access to Affordable Medication 2Health News:PharmacyChecker.com Begins Blog About Americans' Access to Affordable Medication 3Health News:PharmacyChecker.com Begins Blog About Americans' Access to Affordable Medication 4Health News:Cymetrix Board Member Recognized for Enhancing the Growth and Operations of the Companies He Advises 2Health News:Cymetrix Board Member Recognized for Enhancing the Growth and Operations of the Companies He Advises 3Health News:Cymetrix Board Member Recognized for Enhancing the Growth and Operations of the Companies He Advises 4Health News:WebMD Health Foundation Honored as Leader in Health by CancerCare 2Health News:WebMD Health Foundation Honored as Leader in Health by CancerCare 3Health News:Baby Quasar Now Available at Neiman Marcus 2Health News:Baby Quasar Now Available at Neiman Marcus 3Health News:Baby Quasar Now Available at Neiman Marcus 4Health News:Baby Quasar Now Available at Neiman Marcus 5Health News:A critical moment in the field of lung cancer 2
(Date:4/17/2015)... 17, 2015 Today, the Pharmaceutical Research ... from 12 biopharmaceutical companies as "We Work For ... advocacy and community service. Established in ... were created by the biopharmaceutical industry to honor ... careers, but have also shown an outstanding commitment ...
(Date:4/17/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/kh5kqg/the_corporate ) ... Corporate Reputation of Pharma - The Patient Perspective ... to their offering. The Corporate Reputation ... its fourth edition. This report contains the latest ... annual Corporate Reputation report, the author surveys a ...
(Date:4/17/2015)... 2015 Bionomics Limited (ASX:BNO, ADR:BMICY), a biopharmaceutical ... therapeutics for the treatment of cancer and diseases of ... data from three of its most advanced oncology programs ... 106 th Annual Meeting being held from April ... USA. The presentation on the BNC105 ...
Breaking Medicine Technology:PhRMA Applauds 2015 We Work For Health Champion Award Winners 2PhRMA Applauds 2015 We Work For Health Champion Award Winners 3The Corporate Reputation of Pharma - The Global Patient Perspective in 2014 2Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 2Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 3Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 4Bionomics Showcases Oncology Drug Development Programs at 2015 AACR Annual Meeting 5
... manufactures its signature line of award-winning flip-up ... These next generation loupes feature extremely ... and are multi-coated lens for anti-glare, anti-fog, ... Sport frame offers a stylish, yet comfortable ...
... first manufacturer to offer through-the-lens (TTL) ... These next generation loupes feature extremely ... design, and are multi-coated lens for ... SheerVision's proprietary SureFit system - you ...
Adjustable Velcro© closures at crown and behind the neck distinguish this immediate post-op face and chin garment for maximum support and compression....
Very compressive support for submental liposuction...
Medicine Products: