Navigation Links
Cancer drug shows promise against graft vs. host disease
Date:7/10/2008

ANN ARBOR, Mich. A new University of Michigan study in mice suggests that a drug recently approved to fight cancer tumors is also able to reduce the effects of graft-versus-host disease, a common and sometimes fatal complication for people who have had bone marrow transplants.

Plans are under way at U-M for an initial trial of the drug in people as a new way to prevent graft-versus-host disease. Researchers expect to begin a trial within a year.

The U-M scientists tested the effects of the drug SAHA, as well as another member of a group of drugs known as HDAC inhibitors, on key immune system cells called dendritic cells. In mice, both drugs were able to significantly diminish the destructive inflammatory effects that these cells cause in graft-versus-host disease.

Graft-versus-host disease occurs when immune cells in the transplanted bone marrow mount a misguided attack on body tissues. If HDAC inhibitors turn out to be safe and effective in people, they might offer a treatment option preferable to the immunosuppressant drugs used now to treat the disease. These leave people vulnerable to infection and have other significant side effects.

"To make bone marrow transplants more effective, we need better control of the very powerful reactions between the immune systems of the donor and recipient. This study shows how drugs like SAHA regulate those reactions, and takes us a major step closer to bringing this new approach to patients who need transplants," says James L.M. Ferrara, M.D., director of the U-M Combined Bone Marrow Transplant Program and a senior author on the study. Ferrara is also professor of internal medicine and pediatric and communicable diseases at U-M.

"These HDAC inhibitors were thought to just kill cancer cells, but at lower doses, it's possible they can modulate a number of immune diseases," says Pavan Reddy, M.D., the study's lead and corresponding author, and an assistant professor of in
'/>"/>

Contact: Anne Rueter
arueter@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. UTC Contributes $1 Million to Smilow Cancer Hospital
2. A short and sweet diagnosis for cancer?
3. Researchers Gather to Address New Tools in Development for Breast Cancer Detection
4. UAB joins elite brain cancer research group
5. Global Access Project (GAP) Study Examining Patients Access to Cancer Care Featured in the Journal of the American Medical Association (JAMA)
6. Men Often Not Told of Severity of Wifes Cancer
7. Breast-Conserving Surgery Leaves Many Cancer Patients Disappointed
8. Gene Activity May Explain Deadlier Breast Cancers Among Younger Women
9. Localized Online Marketing Campaign Serves to Raise Awareness of Prostate Cancer Treatment
10. Rumors Dispelled Over Univision Talent Fernando Del Rincons Cancer Diagnosis Being Fabricated
11. Study finds that significant proportion of men told wifes cancer was incurable late or not at all
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cancer drug shows promise against graft vs. host disease
(Date:4/26/2015)... FL (PRWEB) April 26, 2015 India ... pioneered in delivering valuable community services to the Asian ... developmental projects in India for more than two decades. ... hundreds and thousands of subscribers around the world with ... source at that time. The Immigration Law Forum Digest, ...
(Date:4/26/2015)... (PRWEB) April 26, 2015 In an article ... State University evaluated the head-neck biomechanics occurring during the use ... study were able to determine that use of a tablet ... 3 to 5 times - more than when the neck ... for such a study, but pointing out the potential hazards ...
(Date:4/26/2015)... April 26, 2015 The grand celebration got ... by Deb Dettor, CCAR’s Managing Director. Deb then introduced Sandy ... was not in attendance because of his Walk for ... Phil was able to express his gratitude to the volunteers ... for their dedication to carrying out CCAR’s mission. Volunteer ...
(Date:4/25/2015)... DC (PRWEB) April 26, 2015 The ... Seniors (ACE.S) , a national endeavor to prepare nurses ... adults, is a great success, according to a new ... the program's original funding partners. , The project ... of Philadelphia (CCP), under the direction of Elaine Tagliareni, ...
(Date:4/25/2015)... 26, 2015 Avid Collector Andrew Hawley ... Rolling Stones Greensboro Coliseum concert posters. The concert was ... the Stone's Second American Tour. , According to ... out of Baltimore, Maryland. This poster blank was used ... southern cites. Globe uses garish lettering and colors on ...
Breaking Medicine News(10 mins):Health News:North American Telugu Society Bestows Community Service Award to India Network Foundation for Its Generosity and Sponsor of Visitor Health Insurance to Indian Visitors 2Health News:North American Telugu Society Bestows Community Service Award to India Network Foundation for Its Generosity and Sponsor of Visitor Health Insurance to Indian Visitors 3Health News:Avoiding the Pain in the Neck Caused by Overuse of Technology 2Health News:Avoiding the Pain in the Neck Caused by Overuse of Technology 3Health News:Avoiding the Pain in the Neck Caused by Overuse of Technology 4Health News:The Connecticut Community for Addiction Recovery (CCAR) honors its volunteers during National Volunteer Recognition Week. 2Health News:Hartford Foundation Report Details Success of NLN's Advancing Care Excellence for Seniors (ACE.S) Program 2Health News:Hartford Foundation Report Details Success of NLN's Advancing Care Excellence for Seniors (ACE.S) Program 3
... during the past three decades in at least one ... up the habit, according to research presented at the ... Survey, a population-based, serial cross-sectional study of trends in ... in each of its six surveys. Examining the ...
... treat kidney disease; of that population nearly half of ... Dialysis patients are at elevated risk for sudden ... occur because little research has been done to examine ... population. Northwestern Medicine cardiologist Rod Passman, ...
... the months following the death of a spouse or a child, ... heart attack or sudden cardiac death due to an increased heart ... six months, the study authors said. "While the focus at ... the health and welfare of bereaved survivors should also be of ...
... , SATURDAY, Nov. 13 (HealthDay News) -- When implemented, ... (CPR) can dramatically boost survival rates among people being ... expert report. A case report on the effectiveness ... Saturday at the AHA,s annual meeting in Chicago by ...
... Jenifer Goodwin HealthDay Reporter , FRIDAY, Nov. ... to themselves as "stroke centers of excellence" or "chest ... care for stroke and heart attacks. But current ... of the best cardiovascular or stroke care are falling ...
... in 28 years. At 44, he,s one of the youngest ... of "goat" once they,ve completed 20 or more "Macs", the ... sailed the race every year since he was 16. But, ... was in intensive care awaiting heart transplant following a harrowing ...
Cached Medicine News:Health News:Smoking among some adults dropped dramatically in past three decades 2Health News:Smoking among some adults dropped dramatically in past three decades 3Health News:Smoking among some adults dropped dramatically in past three decades 4Health News:Smoking among some adults dropped dramatically in past three decades 5Health News:Smoking among some adults dropped dramatically in past three decades 6Health News:Patients receiving dialysis are at a heightened risk for sudden cardiac death 2Health News:Patients receiving dialysis are at a heightened risk for sudden cardiac death 3Health News:Death of Loved One May Trigger Elevated Heart Rate 2Health News:CPR Guidelines May Lower Out-of-Hospital Death Rate 2Health News:Setting National Hospital Standards Could Boost Cardiac Care 2Health News:Setting National Hospital Standards Could Boost Cardiac Care 3Health News:Myocarditis can attack hearts without warning 2
(Date:4/24/2015)... , und BARCELONA , ... Nr. 4410) iCAD, Inc. (Nasdaq: ICAD ... Bildanalyse, Lösungen für Behandlungsabläufe und Strahlentherapie für ... heute die sofortige Verfügbarkeit des ersten Xoft ... (eBx ® ) System ® in ...
(Date:4/24/2015)... -- Bayer Corporation hosted its annual "Take Your Child to Work ... headquarters.  This is Bayer,s second "Take Your Child To Work ... campus, and Thursday,s event welcomed 230 children ready to see ... Fortunately, for the kids, this was not just another ... "Science For A Better Life," Bayer made sure that "Take ...
(Date:4/24/2015)... , April 24, 2015   Vestagen Technical Textiles, ... VESTEX ® , has recently received two notable innovation ... global competition that recognizes innovations with potential to create ... last night in New York City ... Material Science "Protection & Safety" category. The awards honor ...
Breaking Medicine Technology:Erste Klinik in Spanien setzt das Xoft Electronic Brachytherapy System für die Behandlung von Brustkrebs im Frühstadium, nicht-melanozytärem Hautkrebs und gynäkologischen Krebserkrankungen ein 2Erste Klinik in Spanien setzt das Xoft Electronic Brachytherapy System für die Behandlung von Brustkrebs im Frühstadium, nicht-melanozytärem Hautkrebs und gynäkologischen Krebserkrankungen ein 3Erste Klinik in Spanien setzt das Xoft Electronic Brachytherapy System für die Behandlung von Brustkrebs im Frühstadium, nicht-melanozytärem Hautkrebs und gynäkologischen Krebserkrankungen ein 4Erste Klinik in Spanien setzt das Xoft Electronic Brachytherapy System für die Behandlung von Brustkrebs im Frühstadium, nicht-melanozytärem Hautkrebs und gynäkologischen Krebserkrankungen ein 5Erste Klinik in Spanien setzt das Xoft Electronic Brachytherapy System für die Behandlung von Brustkrebs im Frühstadium, nicht-melanozytärem Hautkrebs und gynäkologischen Krebserkrankungen ein 6Bayer Hosts "Take Your Child to Work Day" 2Bayer Hosts "Take Your Child to Work Day" 3Bayer Hosts "Take Your Child to Work Day" 4VESTEX Wins Innovation Honors from Edison Awards & Apparel Magazine 2VESTEX Wins Innovation Honors from Edison Awards & Apparel Magazine 3
... Artis dFC Magnetic Navigation was developed ... Magnetic catheter navigation is a unique, ... cardiology. Assisted by two cutting-edge magnets, ... catheter and guide wires through the ...
The AXIOM Artis TC is ideal for applications above and beyond standard cardioangiography, and features:, Single plane C-Arm, ceiling-mounted, Full-size CCD camera, ...
... system PLUS is ... transesophageal cardiovascular imaging system ... array echocardiography system that provides ... even on your most technically ...
MAGNETOM Symphony, an imaging system that offers 1.5T performance and top image quality in a short bore design....
Medicine Products: