Navigation Links
Cancer drug may also work for scleroderma
Date:9/22/2011

CHICAGO --- A drug used to treat cancer may also be effective in diseases that cause scarring of the internal organs or skin, such as pulmonary fibrosis or scleroderma.

The drug, with the generic name bortezomib, stopped the production of fibrotic proteins in human cells and the development of fibrous scarring in a mouse model of fibrotic disease, according to a new Northwestern Medicine study published in the journal Thorax.

"This drug appears to put the brakes on abnormal development of scar tissue in the lungs and skin and may also work in other organs," said lead author Manu Jain, M.D., associate professor of medicine and of pediatrics at Northwestern University Feinberg School of Medicine and a physician at Northwestern Memorial Hospital and Children's Memorial Hospital. "These diseases have a high fatality rate, and there is no truly effective treatment for them right now."

Scleroderma is an autoimmune disease that causes progressive thickening and tightening of the skin and can lead to serious internal organ damage and, in some cases, death. Scleroderma affects an estimated 300,000 people in the United States, most frequently young to middle-aged women.

Idiopathic pulmonary fibrosis is a scarring or thickening of the lungs without any known cause that makes it increasingly difficult to breathe. It may affect up to 200,000 people in the U.S. between 50 and 70 years old.

Jain said the drug appears to inhibit a protein called transforming growth factor beta, which is essential for the growth of the scar tissue. Patients with fibrosis have increased levels and activity of the growth factor. Bortezomib is currently used to treat multiple myeloma and lymphoma.

In the study, when researchers gave bortezomib to mice, it prevented the development of a fibrotic-like disease. "The mice that normally get this disease didn't get it," Jain said.

Researchers also took fibroblast cells from scleroderma and pulmonary fibrosis patients and incubated those cells with the drug. Fibroblast cells are believed to be important in the development of scarring in humans. The drug prevented the expression of proteins that are necessary for scarring.


'/>"/>

Contact: Marla Paul
Marla-Paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Related medicine news :

1. Popular Diabetes Drugs May Raise Pancreatic Cancer Risk, Study Suggests
2. Virus kills breast cancer cells in laboratory
3. Lung cancer research team awarded $1.43 million to study cancer in Eastern Kentucky
4. TGen-Virginia G. Piper Cancer Center launches clinical trial for drug to treat lung cancer
5. New Test Predicts Risk for Impotence After Prostate Cancer Therapy
6. Genes May Explain Blacks Bleaker Prostate Cancer Stats
7. The War on Cancer Continues
8. John Theurer Cancer Center among first clinical trial sites to join landmark MMRF study
9. MRI Can Spot Breast Cancer in High-Risk Women: Study
10. Higher Risk of Second Breast Cancer Seen in Black Women
11. 10 ways to make better decisions about cancer care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/17/2017)... ... August 17, 2017 , ... Dr. Charles W. Grimsley’s new ... ($15.99, paperback, 9781498497626; $7.99, eBook, 9781498497633) focuses on the treatment of veterans diagnosed ... achieve forgiveness, through a progressive journey toward healing. This book will help readers ...
(Date:8/17/2017)... , ... August 17, 2017 , ... Advice Media, the industry leader in digital marketing ... in North America and has been included in the Inc. 5000 for the second time ... to be included in the Inc. 5000 rankings for the second year in a row. ...
(Date:8/16/2017)... ... August 16, 2017 , ... Summer days spent with family are priceless. ... put together suggestions for enjoying the season of sunshine. Add trying something new to ... family can join in on the fun. , Try Something New ...
(Date:8/16/2017)... ... August 16, 2017 , ... Ten outstanding teachers in the Greater ... Classroom and will win a visit by a Houston Texans player, two tickets to ... least five years old can visit texanschecking.com/stars to nominate their favorite teacher with an ...
(Date:8/16/2017)... (PRWEB) , ... August 16, 2017 , ... In a ... its appearance with diet and exercise. In fact, cellulite can't always be eliminated by ... and more effective treatment available to select physicians nationwide. Dr. Kenneth Rothaus has recently ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... Aug. 15, 2017   Mostyn Law and Gulf Coast ... Houston, Texas . The Mostyn Law family has ... years. That is why Mostyn Law is partnering with ... to show its appreciation. Blood supplies are running low. ... short of hospital needs in August. That is why the blood ...
(Date:8/14/2017)... Israel , Aug. 15, 2017 /PRNewswire/ ... of adult stem cell technologies for neurodegenerative diseases, announced ... 2017. "We are ... Phase 3 trial to investigate NurOwn ® in ... Executive Officer of BrainStorm. "We have agreements with Mass. ...
(Date:8/7/2017)... 7, 2017 Insightin Health, provider of ... and engagement, announced the selection of Michael ... Development, effective as of February 2017. In this role, ... strategy for our clients. Wood brings with him ... and business analytics within the healthcare industry. Wood ...
Breaking Medicine Technology: