Navigation Links
Cancer drug may also work for scleroderma
Date:9/22/2011

CHICAGO --- A drug used to treat cancer may also be effective in diseases that cause scarring of the internal organs or skin, such as pulmonary fibrosis or scleroderma.

The drug, with the generic name bortezomib, stopped the production of fibrotic proteins in human cells and the development of fibrous scarring in a mouse model of fibrotic disease, according to a new Northwestern Medicine study published in the journal Thorax.

"This drug appears to put the brakes on abnormal development of scar tissue in the lungs and skin and may also work in other organs," said lead author Manu Jain, M.D., associate professor of medicine and of pediatrics at Northwestern University Feinberg School of Medicine and a physician at Northwestern Memorial Hospital and Children's Memorial Hospital. "These diseases have a high fatality rate, and there is no truly effective treatment for them right now."

Scleroderma is an autoimmune disease that causes progressive thickening and tightening of the skin and can lead to serious internal organ damage and, in some cases, death. Scleroderma affects an estimated 300,000 people in the United States, most frequently young to middle-aged women.

Idiopathic pulmonary fibrosis is a scarring or thickening of the lungs without any known cause that makes it increasingly difficult to breathe. It may affect up to 200,000 people in the U.S. between 50 and 70 years old.

Jain said the drug appears to inhibit a protein called transforming growth factor beta, which is essential for the growth of the scar tissue. Patients with fibrosis have increased levels and activity of the growth factor. Bortezomib is currently used to treat multiple myeloma and lymphoma.

In the study, when researchers gave bortezomib to mice, it prevented the development of a fibrotic-like disease. "The mice that normally get this disease didn't get it," Jain said.

Researchers also took fibroblast cells from scleroderma and pulmonary fibrosis patients and incubated those cells with the drug. Fibroblast cells are believed to be important in the development of scarring in humans. The drug prevented the expression of proteins that are necessary for scarring.


'/>"/>

Contact: Marla Paul
Marla-Paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Related medicine news :

1. Popular Diabetes Drugs May Raise Pancreatic Cancer Risk, Study Suggests
2. Virus kills breast cancer cells in laboratory
3. Lung cancer research team awarded $1.43 million to study cancer in Eastern Kentucky
4. TGen-Virginia G. Piper Cancer Center launches clinical trial for drug to treat lung cancer
5. New Test Predicts Risk for Impotence After Prostate Cancer Therapy
6. Genes May Explain Blacks Bleaker Prostate Cancer Stats
7. The War on Cancer Continues
8. John Theurer Cancer Center among first clinical trial sites to join landmark MMRF study
9. MRI Can Spot Breast Cancer in High-Risk Women: Study
10. Higher Risk of Second Breast Cancer Seen in Black Women
11. 10 ways to make better decisions about cancer care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... ... January 24, 2017 , ... The health insurance industry is ... (AEP) and the Open Enrollment Period (OEP). 2016 was no exception. If anything, ... witnessing higher deductibles, rising premiums, and few choices with their insurance, which is ...
(Date:1/24/2017)... ... , ... The Cruise Web Inc. was recognized today as Northeast ... Annual MSC True Partnerships’ Awards. , The 2016 MSC True Partnerships Awards are ... on overall business growth in revenue and guests and continuous partnership support and innovative ...
(Date:1/24/2017)... ... January 24, 2017 , ... OMI Industries, a worldwide leader ... distribution partnership with Byers Scientific & Manufacturing , a leading designer, engineer ... agreement, OMI Industries formulated a special version of Ecosorb® for Byers Scientific & ...
(Date:1/24/2017)... Hill, N.C. (PRWEB) , ... January 24, 2017 ... ... Trump Administration is the focus of a new report from the Frank ... Kenan-Flagler Business School. , Influential business leaders, academics and policy makers identified concrete ...
(Date:1/24/2017)... ... January 24, 2017 , ... Date aired: January 23, 2017 ... the nation’s foremost water advocate and host of the nationally syndicated The Sharon ... America, once again welcomed one of her favorite guests and colleagues, Dr. Gerald ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... Md. , Jan. 24, 2017   Intrexon Corporation ... engineering and industrialization of biology to improve the quality of ... has entered into a definitive agreement to acquire GenVec, ... and pioneer in the development of AdenoVerse™ gene delivery technology.  ... GenVec,s expertise in adenoviral vectors and cGMP drug product manufacturing ...
(Date:1/24/2017)... , Jan. 24, 2017   QR ... biopharmaceutical company developing novel therapies for the treatment ... announced the appointment of four world-class key opinion ... new appointments join QR Pharma,s previous roster of ... and direction to support the development of the ...
(Date:1/24/2017)... Research and Markets has announced the addition of the "Optogenetics ... report to their offering. ... Global Optogenetics Market is poised to grow at ... approximately $76.24 million by 2025. Some of the prominent ... using optogentic techniques for neurosciences, quick growth ultrafast laser tools technology, ...
Breaking Medicine Technology: