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Cancer drug linked to quantum dots increases drug uptake, reduces inflammation
Date:11/1/2010

ich play a critical role in the pathogenesis of various inflammatory lung injuries.

"The aM is the sentinel cell involved in directing the host innate and adaptive immune responses involved in infectious and non-infectious lung diseases such as COPD," notes Chakravarthy. "The aM's central role in response to environmental influences makes these cells an ideal candidate for targeted drug delivery to modulate the immune/inflammatory response."

To test the ability of linked quantum dot-doxorubicin (QD-DOX) to decrease lung inflammation, the researchers delivered QD-DOX or doxorubicin alone to rats and mice and assessed the damage to the lung. Doxorubicin, a frequently used cancer drug, is known to cause a variety of damaging immune responses in cancer patients.

Results showed that QD-DOX increased uptake of the drug compared with doxorubicin alone, and did not cause as significant a pro-inflammatory response as doxorubicin alone. The researchers also demonstrated that the drug is released from the QD-DOX formulation once it is delivered into the targeted cell and still retains its bioactivity.

"Based on these results, we believe that linking quantum dots with therapeutic drugs may have tremendous potential for diagnosis and treatment of lung injury compared to other nanoparticle formulations, and should be further developed for lung pharmacotherapy applications," says Chakravarthy.


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Contact: Lois Baker
ljbaker@buffalo.edu
716-645-4606
University at Buffalo
Source:Eurekalert  

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