Navigation Links
Cancer drug linked to quantum dots increases drug uptake, reduces inflammation
Date:11/1/2010

BUFFALO, N.Y. -- Researchers at the University at Buffalo have developed a novel technology using quantum dots that is expected to have major implications for research and treatment of tuberculosis, as well as other inflammatory lung diseases.

A paper appearing online in Nanomedicine: Nanotechnology, Biology and Medicine as an article-in-press describes specific delivery of a chemotherapeutic drug to specific cells in the lung, particularly the alveolar white cell, without causing acute inflammation. Quantum dots are tiny semiconductor particles generally no larger than 10 nanometers that can be made to fluoresce in different colors depending on their size. Scientists are interested in quantum dots because they are a superb carrier and last much longer than conventional dyes used to tag molecules, which usually stop emitting light in seconds.

"The ability to target specific cells in the lung without exposing surrounding cells and tissue or distant organs to the detrimental effects of drugs is an exciting avenue to explore," says Krishnan V. Chakravarthy, PhD, a research fellow in the UB School of Medicine and Biomedical Sciences joint MD/PhD program and lead author on the paper.

"We have been able to prove this in both cultured cells and in animals," he continues. "The technology is still in its infancy, but being able to conduct these experiments in the whole animal makes it more promising as a clinical application. The long-term goal would be to do targeted drug delivery through aerosolized techniques, making it suitable for clinical use."

Researchers in UB's Institute of Lasers, Photonics and Biophotonics have made major advancements in the use of quantum dots, sometimes called artificial atoms, to build new devices for biological and environmental sensing.

In this research, quantum dots were linked with doxorubicin, an anti-cancer chemotherapy drug, to target specific lung cells, known as alveolar macrophages (aM) which play a critical role in the pathogenesis of various inflammatory lung injuries.

"The aM is the sentinel cell involved in directing the host innate and adaptive immune responses involved in infectious and non-infectious lung diseases such as COPD," notes Chakravarthy. "The aM's central role in response to environmental influences makes these cells an ideal candidate for targeted drug delivery to modulate the immune/inflammatory response."

To test the ability of linked quantum dot-doxorubicin (QD-DOX) to decrease lung inflammation, the researchers delivered QD-DOX or doxorubicin alone to rats and mice and assessed the damage to the lung. Doxorubicin, a frequently used cancer drug, is known to cause a variety of damaging immune responses in cancer patients.

Results showed that QD-DOX increased uptake of the drug compared with doxorubicin alone, and did not cause as significant a pro-inflammatory response as doxorubicin alone. The researchers also demonstrated that the drug is released from the QD-DOX formulation once it is delivered into the targeted cell and still retains its bioactivity.

"Based on these results, we believe that linking quantum dots with therapeutic drugs may have tremendous potential for diagnosis and treatment of lung injury compared to other nanoparticle formulations, and should be further developed for lung pharmacotherapy applications," says Chakravarthy.


'/>"/>

Contact: Lois Baker
ljbaker@buffalo.edu
716-645-4606
University at Buffalo
Source:Eurekalert  

Related medicine news :

1. Management science guru, surviving cancer, offers hope to fellow sufferers, doctors
2. UCI non-small cell lung cancer study highlights advances in targeted drug therapy
3. Peptide being tested to treat atherosclerosis inhibits ovarian cancer growth
4. Research explores lung cancer among pediatric cancer patients
5. Pitt study finds NSAIDs cause stem cells to self-destruct, preventing colon cancer
6. Scientists turn a new leaf to discover a compound in daffodils that targets brain cancer
7. Race may influence uterine cancer recurrence, despite treatment
8. Dads Family History of Breast, Ovarian Cancer Matters, Too
9. Breast density, no lobular involution increase breast cancer risk
10. Mouse Study Reveals a Cancer Cell Escape Route
11. Stereotactic radiotherapy slows pancreatic cancer progression for inoperable patients
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cancer drug linked to quantum dots increases drug uptake, reduces inflammation
(Date:4/29/2016)... ... April 29, 2016 , ... The American workforce ... stability, even security. Most importantly, employees are the single most important asset in ... workers so unhappy? , Just under half of American workers are emotionally checked ...
(Date:4/29/2016)... ... April 29, 2016 , ... Conditions were ideal for Global Lyme ... on Sunday, with sunny skies, a light breeze and temperatures in the 60s. Over ... The 5k Run and Walk and 1-mile walk were held to increase awareness ...
(Date:4/29/2016)... , ... April 29, 2016 , ... Spine Team Texas, ... is proud to announce one of their physicians has been invited to be a ... (Texas ACOFP) Family Practice Review conference on April 30, 2016. , Dr. R. ...
(Date:4/29/2016)... NY (PRWEB) , ... April 29, 2016 , ... ... and engineer of patented products, announces the Gyrociser, an exercise invention which aids ... worth $2 billion," says Scott Cooper, CEO and Creative Director of World Patent ...
(Date:4/29/2016)... ... April 29, 2016 , ... Dr. Robert Mondavi, one of the ... Cosmetic dentistry is a fast-growing field as more patients are discovering the many different ... more about the options currently available to them and which ones might work for ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... --   , Total Sales ... Sales  Clinical sales grow 16% year-over-year  , ... OTCQX: MKEAY) inventor of Cellvizio®, the multidisciplinary confocal laser ... quarter ended March 31, 2016 and provided an update ... strategy. First Quarter 2016 Revenue Results by ...
(Date:4/27/2016)... , April 27, 2016 ... titled, "Skincare Devices Market - Global Industry Analysis, Size, ... to the report, the global skincare devices market was ... anticipated to expand at a CAGR of 10.1% from ... 2023. Browse the full Skincare Devices Market (Treatment ...
(Date:4/27/2016)... NEW DELHI , April 27, 2016 ... CSR initiative to save newborns ... ,s hospital for women & newborns in collaboration with Breast ... has launched the first Pasteurized Human Milk Bank, ,Amaara, in ... the best nutritional food source for infants and should be ...
Breaking Medicine Technology: